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Epigenetic control of variation and stochasticity in metabolic disease.

Abstract：

BACKGROUND:The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex trait disorders with only partial genetic heritability, indicating important roles for environmental programing and epigenetic effects. SCOPE OF THE REVIEW:We will highlight some of the reasons for the scarce predictability of metabolic diseases. We will outline how genetic variants generate phenotypic variation in disease susceptibility across populations. We will then focus on recent conclusions about epigenetic mechanisms playing a fundamental role in increasing variability and subsequently disease triggering. MAJOR CONCLUSIONS:Currently, we are unable to predict or mechanistically define how "missing heritability" drives disease. Unravelling this black box of regulatory processes will allow us to move towards a truly personalized and precision medicine.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Panzeri I,Pospisilik JA

doi

10.1016/j.molmet.2018.05.010

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

26-38

issn

2212-8778

pii

S2212-8778(18)30198-4

journal_volume

14

pub_type

杂志文章,评审

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