abstract：AIM:The effects of social isolation measures used to control the spread of COVID-19 are negatively impacting the mental health of many. One of the consequences of exposure to disasters/pandemics is an increase in alcohol use. The current study aimed to examine what predisposing (distal) and pandemic-related (proximal) ...

journal_title：Psychiatry and clinical neurosciences

authors： Neill E,Meyer D,Toh WL,van Rheenen TE,Phillipou A,Tan EJ,Rossell SL

更新日期：2020-10-01 00:00:00

abstract：AIM:Recent cognitive neuroscience research shows that noninvasive brain stimulation can modify a wide range of behaviors in healthy people. Such regulation effects on human behaviors provide new insights into the neurobiology of cognitive processes and establish causal brain-behavior relations. Here, we aimed to examin...

journal_title：Psychiatry and clinical neurosciences

authors： Khaleghi A,Pirzad Jahromi G,Zarafshan H,Mostafavi SA,Mohammadi MR

更新日期：2020-09-01 00:00:00

abstract：AIM:This systematic review and meta-analysis evaluated whether bright light therapy (BLT) is an effective and safe treatment for manic/depressive symptoms and a preventive measure for recurrent mood episodes in patients with bipolar disorder. METHODS:A literature search of major electronic databases was conducted in J...

journal_title：Psychiatry and clinical neurosciences

authors： Takeshima M,Utsumi T,Aoki Y,Wang Z,Suzuki M,Okajima I,Watanabe N,Watanabe K,Takaesu Y

更新日期：2020-04-01 00:00:00

abstract：:While neurons of the human cerebral cortex are mainly distributed in the gray matter, the white matter (WM) also contains some excitatory and inhibitory neurons, so-called WM neurons. Studies on the cytoarchitectural alterations in the brains of patients with neuropsychiatric disorders have repeatedly reported increas...

journal_title：Psychiatry and clinical neurosciences

authors： Kubo KI

更新日期：2020-03-01 00:00:00

abstract：AIM:Glial fibrillary acidic protein (GFAP), the intermediate filament protein expressed in astrocytes, plays a key role in many aspects of brain function through communication with neurons or blood vessels. A common single nucleotide polymorphism (SNP), GFAP -250 C/A (rs2070935), is associated with the transcriptional ...

journal_title：Psychiatry and clinical neurosciences

authors： Takahashi Y,Takeuchi H,Sakai M,Yu Z,Kikuchi Y,Ito F,Matsuoka H,Tanabe O,Yasuda J,Taki Y,Kawashima R,Tomita H

更新日期：2020-01-01 00:00:00

abstract：AIM:Prescription opioids are psychoactive substances that can elicit many neuropsychological effects. There are no studies that directly demonstrate the effects of prescription opioid addiction (POA) on the human brain. This study aimed to quantify γ-aminobutyric acid (GABA) and glutamate (Glu) levels in the prefrontal...

journal_title：Psychiatry and clinical neurosciences

authors： Li JN,Liu XL,Li L

更新日期：2020-01-01 00:00:00

abstract：:Stress caused by adverse and demanding conditions, a risk factor for mental illnesses, induces adaptive or maladaptive neural and behavioral consequences, depending on the conditions. Studies using rodent stress models have revealed multiple mechanisms related to dopamine and inflammation for stress-induced neural and...

journal_title：Psychiatry and clinical neurosciences

authors： Furuyashiki T,Kitaoka S

更新日期：2019-11-01 00:00:00

abstract：AIM:The aim of this study was to identify women with thoughts of self-harm preceded by suicidal ideation, during the perinatal period, on cluster analysis and to clarify their psychological correlates. METHODS:A secondary analysis was conducted using the data from a longitudinal study involving 18 obstetric clinics be...

journal_title：Psychiatry and clinical neurosciences

authors： Takegata M,Takeda S,Sakanashi K,Tanaka T,Kitamura T

更新日期：2019-11-01 00:00:00

abstract：AIM:Tissue pH and RNA integrity are crucial quality-control indicators of human post-mortem brain tissues in the identification of the pathogeneses of neuropsychiatric disorders, but pH has not been measured as often due to limitations in the amount of tissue available. This study was designed to develop and validate a...

journal_title：Psychiatry and clinical neurosciences

authors： Ono CT,Yu Z,Kikuchi Y,Kunii Y,Hino M,Matsumoto J,Nagaoka A,Ito J,Iwasaki Y,Hagihara H,Miyakawa T,Yoshida M,Saito Y,Niwa SI,Yabe H,Kakita A,Tomita H

更新日期：2019-09-01 00:00:00

abstract：AIM:Neuroimaging-based multivariate pattern-recognition methods have been successfully used to develop diagnostic algorithms to distinguish patients with major depressive disorder (MDD) from healthy controls (HC). We developed and evaluated the accuracy of a multivariate classification method for the differentiation of...

journal_title：Psychiatry and clinical neurosciences

authors： Ramasubbu R,Brown EC,Marcil LD,Talai AS,Forkert ND

更新日期：2019-08-01 00:00:00

abstract：:A high disease burden of mental disorders has been noted worldwide, including Japan. It is important to monitor mental disorder prevalence trends and the use of mental health services over time using epidemiological data and to plan appropriate policies and measures that consider mental health in each country. This re...

journal_title：Psychiatry and clinical neurosciences

authors： Nishi D,Ishikawa H,Kawakami N

更新日期：2019-08-01 00:00:00

abstract：:Hikikomori, a severe form of social withdrawal, has long been observed in Japan mainly among youth and adolescents since around the 1970s, and has been especially highlighted since the late 1990s. Moreover, hikikomori-like cases have recently been reported in many other countries. Hikikomori negatively influences not ...

journal_title：Psychiatry and clinical neurosciences

authors： Kato TA,Kanba S,Teo AR

更新日期：2019-08-01 00:00:00

abstract：AIM:Prior structural magnetic resonance imaging studies demonstrated atypical gray matter characteristics in siblings of individuals with autism spectrum disorder (ASD). However, they did not clarify which aspect of gray matter is related to the endophenotype (i.e., genetic vulnerability) of ASD. Further, because they ...

journal_title：Psychiatry and clinical neurosciences

authors： Yamagata B,Itahashi T,Fujino J,Ohta H,Takashio O,Nakamura M,Kato N,Mimura M,Hashimoto RI,Aoki YY

更新日期：2019-07-01 00:00:00

abstract：:While post-traumatic stress disorder (PTSD) is currently diagnosed based solely on classic psychological and behavioral symptoms, a growing body of evidence has highlighted a link between this disorder and alterations in the immune and inflammatory systems. Epidemiological studies have demonstrated that PTSD is associ...

journal_title：Psychiatry and clinical neurosciences

authors： Hori H,Kim Y

更新日期：2019-04-01 00:00:00

abstract：AIM:Although peripheral low-grade inflammation and brain-derived neurotrophic factor (BDNF) levels have been implicated in schizophrenia (SCZ), the interactions between them remain to be fully revealed. We aimed to compare BDNF and cytokines in patients with SCZ and healthy controls (HC). Additionally, we aimed to inve...

journal_title：Psychiatry and clinical neurosciences

authors： Zhou Y,Peng W,Wang J,Zhou W,Zhou Y,Ying B

更新日期：2019-03-01 00:00:00

abstract：AIM:Impulsivity, which significantly affects social adaptation, is an important target behavioral characteristic in interventions for attention-deficit hyperactivity disorder (ADHD). Typically, people are willing to wait longer to acquire greater rewards. Impulsivity in ADHD may be associated with brain dysfunction in ...

journal_title：Psychiatry and clinical neurosciences

authors： Todokoro A,Tanaka SC,Kawakubo Y,Yahata N,Ishii-Takahashi A,Nishimura Y,Kano Y,Ohtake F,Kasai K

更新日期：2018-08-01 00:00:00

abstract：AIM:This study examined catechol-O-methyltransferase (COMT) DNA methylation in the peripheral blood of schizophrenia patients and also in healthy controls to investigate its potential use as a peripheral biomarker of schizophrenia and its relations with the clinical variables of schizophrenia patients. METHODS:We exam...

journal_title：Psychiatry and clinical neurosciences

authors： Nour El Huda AR,Norsidah KZ,Nabil Fikri MR,Hanisah MN,Kartini A,Norlelawati AT

更新日期：2018-04-01 00:00:00

abstract：AIM:Although the association between maternal depression and bonding failure during pregnancy and after delivery has been investigated, the causal relationships remain unclear. METHODS:A total of 751 women (mean [SD] age, 32.1 [4.4] years) completed the Mother-Infant Bonding Questionnaire and the Edinburgh Postnatal D...

journal_title：Psychiatry and clinical neurosciences

authors： Ohara M,Okada T,Kubota C,Nakamura Y,Shiino T,Aleksic B,Morikawa M,Yamauchi A,Uno Y,Murase S,Goto S,Kanai A,Masuda T,Ando M,Ozaki N

更新日期：2017-10-01 00:00:00

abstract：:Oxytocin (OT), often called the 'hormone of love' or 'hormone of attachment,' plays a fundamental role in the establishment and quality of parent-infant bonding. However, emerging evidence indicates that OT can also produce antisocial behavior. To clarify these effects, we review studies examining the role of endogeno...

journal_title：Psychiatry and clinical neurosciences

authors： Szymanska M,Schneider M,Chateau-Smith C,Nezelof S,Vulliez-Coady L

更新日期：2017-10-01 00:00:00

abstract：AIM:Rare variations are suggested to play a role in the genetic etiology of schizophrenia; to further investigate their role, we performed a three-stage study in a Japanese population. METHODS:In the first stage, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. In the second stage, we ...

journal_title：Psychiatry and clinical neurosciences

authors： Hoya S,Watanabe Y,Hishimoto A,Nunokawa A,Inoue E,Igeta H,Otsuka I,Shibuya M,Egawa J,Sora I,Someya T

更新日期：2017-08-01 00:00:00

abstract：:In the last 10 years, numerous neurobiological studies have been conducted on Internet addiction or Internet use disorder. Various neurobiological research methods - such as magnetic resonance imaging; nuclear imaging modalities, including positron emission tomography and single photon emission computed tomography; mo...

journal_title：Psychiatry and clinical neurosciences

authors： Park B,Han DH,Roh S

更新日期：2017-07-01 00:00:00

abstract：:Various perspectives exist regarding Internet gaming disorder. While the concept of behavioral addiction is gaining recognition, some view the phenomenon as merely excessive indulgence in online pastimes. Still, in recent years, complaints from patients or their family members about problems related to Internet use, p...

journal_title：Psychiatry and clinical neurosciences

authors： Lee SY,Lee HK,Choo H

更新日期：2017-07-01 00:00:00

abstract：AIM:We investigated preclinical abnormalities as revealed by transcranial sonography (TCS) in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) compared with those revealed in patients with multiple system atrophy (MSA) or Parkinson's disease (PD) and in normal controls. METHODS:Twenty-two pat...

journal_title：Psychiatry and clinical neurosciences

authors： Li X,Xue S,Jia S,Zhou Z,Qiao Y,Hou C,Wei K,Zheng W,Rong P,Jiao J

更新日期：2017-04-01 00:00:00

abstract：AIM:It is difficult to diagnose dementia with Lewy bodies (DLB) because it exhibits clinical and neuropathological overlap with both Alzheimer's disease and Parkinson's disease. The α-synuclein protein is a major component of Lewy bodies, and accumulation of α-synuclein aggregates causes synaptic dysfunction in DLB. Ep...

journal_title：Psychiatry and clinical neurosciences

authors： Funahashi Y,Yoshino Y,Yamazaki K,Mori Y,Mori T,Ozaki Y,Sao T,Ochi S,Iga JI,Ueno SI

更新日期：2017-01-01 00:00:00

abstract：AIM:Neurofeedback has been studied with the aim of controlling cerebral activity. Near-infrared spectroscopy is a non-invasive neuroimaging technique used for measuring hemoglobin concentration changes in cortical surface areas with high temporal resolution. Thus, near-infrared spectroscopy may be useful for neurofeedb...

journal_title：Psychiatry and clinical neurosciences

authors： Kinoshita A,Takizawa R,Yahata N,Homae F,Hashimoto R,Sakakibara E,Kawasaki S,Nishimura Y,Koike S,Kasai K

更新日期：2016-11-01 00:00:00

abstract：AIM:The aim of this study was to examine over a 12-month post-intervention period whether the participation of community-living individuals with mental illness in cognitive behavioral group therapy for recovery of self-esteem (CBGTRS) resulted in improved outcomes. METHODS:This was a non-randomized controlled trial. T...

journal_title：Psychiatry and clinical neurosciences

authors： Kunikata H,Yoshinaga N,Nakajima K

更新日期：2016-10-01 00:00:00

abstract：AIM:Internet addiction disrupts the daily lives of adolescents. We investigated the prevalence of Internet addiction in junior high school students, elucidated the relation between Internet addiction and mental states, and determined the factors associated with Internet addiction in adolescents. METHODS:Junior high sc...

journal_title：Psychiatry and clinical neurosciences

authors： Kawabe K,Horiuchi F,Ochi M,Oka Y,Ueno S

更新日期：2016-09-01 00:00:00

abstract：AIM:Though genetic factors play a major role in the pathophysiology of psychoses including bipolar disorder (BD) and schizophrenia, lack of well-established causative genetic mutations hampers their neurobiological studies. Darier's disease, an autosomal dominant skin disorder caused by mutations of ATP2A2 on chromosom...

journal_title：Psychiatry and clinical neurosciences

authors： Nakamura T,Kazuno AA,Nakajima K,Kusumi I,Tsuboi T,Kato T

更新日期：2016-08-01 00:00:00

abstract：AIM:Auditory mismatch negativity (MMN) and its magnetoencephalographic (MEG) counterpart (MMNm) are an established biological index in schizophrenia research. MMN in response to duration and frequency deviants may have differential relevance to the pathophysiology and clinical stages of schizophrenia. MEG has advantage...

journal_title：Psychiatry and clinical neurosciences

authors： Suga M,Nishimura Y,Kawakubo Y,Yumoto M,Kasai K

更新日期：2016-07-01 00:00:00

abstract：AIMS:Post-traumatic growth (PTG) refers to positive changes that result from coping with a major life crisis or a traumatic event. Factors influencing PTG in youth have not been well characterized but could have a great impact on overall maturation. METHODS:Fourth to ninth graders (n = 3337) attending elementary or ju...

journal_title：Psychiatry and clinical neurosciences

authors： Yoshida H,Kobayashi N,Honda N,Matsuoka H,Yamaguchi T,Homma H,Tomita H

更新日期：2016-05-01 00:00:00

abstract：AIM:Atypical antipsychotic treatment (e.g. risperidone) has been found to improve social functioning more than standard antipsychotic treatment. However, it is unclear which specific social behaviors are implicated in this improvement. The current study employed an interactive puzzle game to examine how social behavior...

journal_title：Psychiatry and clinical neurosciences

authors： Tse WS,Wong AS,Chan F,Pang AH,Bond AJ,Chan CK

更新日期：2016-05-01 00:00:00

abstract：AIMS:Various eating-related problems are commonly observed among people with dementia, and these problems place a huge burden on the caregivers. An appropriate classification of these problems is important in order to understand their underlying mechanisms and to develop a therapeutic approach for managing them. The ai...

journal_title：Psychiatry and clinical neurosciences

authors： Shinagawa S,Honda K,Kashibayashi T,Shigenobu K,Nakayama K,Ikeda M

更新日期：2016-04-01 00:00:00

abstract：AIMS:Suicide is a leading cause of death among Japanese college and university students. Gatekeeper-training programs have been shown to improve detection and referral of individuals who are at risk of suicide by training non-mental-health professional persons. However, no studies have investigated the effectiveness of...

journal_title：Psychiatry and clinical neurosciences

authors： Hashimoto N,Suzuki Y,Kato TA,Fujisawa D,Sato R,Aoyama-Uehara K,Fukasawa M,Asakura S,Kusumi I,Otsuka K

更新日期：2016-01-01 00:00:00

abstract：AIMS:Previous studies have supported the claim that psychological stress induces the production of reactive oxygen species. Several authors have suggested that patients with psychiatric disorders show high levels of oxidative stress markers. We examined different oxidative stress markers in patients with chronic schizo...

journal_title：Psychiatry and clinical neurosciences

authors： Miyaoka T,Ieda M,Hashioka S,Wake R,Furuya M,Liaury K,Hayashida M,Tsuchie K,Arauchi R,Araki T,Shioji I,Ezoe S,Inoue K,Yamaguchi T,Horiguchi J

更新日期：2015-11-01 00:00:00

abstract：AIMS:The aim of this study was to evaluate the effect of various disease-modifying therapies (DMT) on quality of life in multiple sclerosis (MS). METHODS:This was a three-arm parallel study with balanced randomization in which 90 newly diagnosed, definite MS subjects referred to Ghaem Medical Center, Mashhad, Iran wer...

journal_title：Psychiatry and clinical neurosciences

authors： Mokhber N,Azarpazhooh A,Orouji E,Khorram B,Modares Gharavi M,Kakhi S,Khallaghi H,Azarpazhooh MR

更新日期：2015-10-01 00:00:00

abstract：AIMS:The reasons for accessing and maintaining access to mental health services in Japan may be different to those in other countries. Using the World Health Organization World Mental Health Japan survey data, this study investigated the prevalence of sociodemographic correlates of barriers for the use of, reasons for ...

journal_title：Psychiatry and clinical neurosciences

authors： Kanehara A,Umeda M,Kawakami N,World Mental Health Japan Survey Group.

更新日期：2015-09-01 00:00:00

abstract：AIMS:Suicidal behavior (SB) is a major mental health problem. The research has identified many factors related to SB, such as problems in the developmental period and psychiatric and personality disorders. However, the interrelation of these factors has not been clearly delineated. METHODS:The subjects were 155 patien...

journal_title：Psychiatry and clinical neurosciences

authors： Hayashi N,Igarashi M,Imai A,Yoshizawa Y,Asamura K,Ishikawa Y,Tokunaga T,Ishimoto K,Tatebayashi Y,Kumagai N,Ishii H,Okazaki Y

更新日期：2015-09-01 00:00:00

abstract：AIMS:Alcohol use is the third highest risk factor for disease and disability. This study explored the association between binge drinking and mental health, general health, and diet and nutrition of young adults. METHODS:A sub-sample of 2590 adults aged 18-29 years was selected from 10 364 participants in the survey to...

journal_title：Psychiatry and clinical neurosciences

authors： Mohamed S,Ajmal M

更新日期：2015-08-01 00:00:00

abstract：AIMS:The objectives of this article are to discuss ethical issues of informed consent in cognitively impaired patients and review considerations for capacity determination. We will also discuss how to evaluate capacity, determine competence, and obtain informed consent when a patient is deemed incompetent. This review ...

journal_title：Psychiatry and clinical neurosciences

authors： Fields LM,Calvert JD

更新日期：2015-08-01 00:00:00

abstract：:This review provides a broad overview of the state of research in the genetics of anxiety disorders (AD). Genetic epidemiological studies report a moderate level of familial aggregation (odds ratio: 4-6) and heritability estimates are about 30-50%. Twin studies suggest that the genetic architecture of AD is not isomor...

journal_title：Psychiatry and clinical neurosciences

authors： Shimada-Sugimoto M,Otowa T,Hettema JM

更新日期：2015-07-01 00:00:00