Abstract:
AIM:Glial fibrillary acidic protein (GFAP), the intermediate filament protein expressed in astrocytes, plays a key role in many aspects of brain function through communication with neurons or blood vessels. A common single nucleotide polymorphism (SNP), GFAP -250 C/A (rs2070935), is associated with the transcriptional regulation of GFAP, which can potentially result in the genotype-specific brain structure. This study aimed to verify the biological effects of the GFAP variants on brain structure and function. METHODS:We investigated the associations between the GFAP variants and magnetic resonance imaging findings, including gray and white matter volumes, white matter integrity, and resting arterial blood flow, from 1212 healthy Japanese subjects. RESULTS:The GFAP -250 C/A genotype was significantly associated with total gray matter volume, total white matter volume, average mean diffusivity, and mean cerebral blood flow. In voxel-by-voxel analyses, the GFAP genotype showed significant associations with the regional gray and white matter volumes in the inferior frontal lobe and corpus callosum, the regional mean diffusivity in the left posterior region, and the regional cerebral blood flow throughout the brain. CONCLUSION:This study revealed a common SNP that is significantly associated with multiple global brain structure parameters.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Takahashi Y,Takeuchi H,Sakai M,Yu Z,Kikuchi Y,Ito F,Matsuoka H,Tanabe O,Yasuda J,Taki Y,Kawashima R,Tomita Hdoi
10.1111/pcn.12932subject
Has Abstractpub_date
2020-01-01 00:00:00pages
49-55issue
1eissn
1323-1316issn
1440-1819journal_volume
74pub_type
杂志文章abstract:AIM:Internet addiction disrupts the daily lives of adolescents. We investigated the prevalence of Internet addiction in junior high school students, elucidated the relation between Internet addiction and mental states, and determined the factors associated with Internet addiction in adolescents. METHODS:Junior high sc...
journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/pcn.12526
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.2007.01611.x
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.1998.tb01049.x
更新日期:1998-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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doi:
更新日期:1999-10-01 00:00:00
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doi:10.1111/j.1440-1819.2006.01482.x
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更新日期:2001-06-01 00:00:00
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doi:10.1111/j.1440-1819.2008.01853.x
更新日期:2008-10-01 00:00:00
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更新日期:2001-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1998.00411.x
更新日期:1998-08-01 00:00:00
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更新日期:1998-04-01 00:00:00