abstract：: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...

journal_title：Current medical research and opinion

authors： Sharifan P,Ziaee A,Darroudi S,Rezaie M,Safarian M,Eslami S,Khadem-Rezaiyan M,Tayefi M,Mohammadi M,Ghazizadeh H,Khorasanchi Z,Bagherniya M,Sardar MA,Ferns G,Vatanparast H,Ghayour Mobarhan M

更新日期：2021-01-12 00:00:00

abstract：OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is becoming a leading cause of morbidity and mortality in China. In the IMPACT trial, fluticasone furoate[FF]/umeclidinium[UMEC]/vilanterol[VI] single-inhaler triple therapy demonstrated lower rates of moderate/severe exacerbations than dual therapy with FF/VI or ...

journal_title：Current medical research and opinion

authors： Zheng J,Zhong N,Wang C,Wei LP,Zhou XD,Zhao L,Dong Yuan Y,He B,Wu B,Du X,Song J,Lipson DA

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To assess the burden of treatment-resistant depression (TRD) among privately insured patients with anxiety disorder and/or substance use disorders (SUD). METHODS:Adults <65 years old were identified in the Optum Health Care Solutions Inc. database (July 2009-March 2017). Among those with major depressive dis...

journal_title：Current medical research and opinion

authors： Zhdanava M,Kuvadia H,Joshi K,Daly E,Pilon D,Rossi C,Morrison L,Lefebvre P,Nelson C

更新日期：2021-01-01 00:00:00

abstract：:Background: To investigate the effects of 1-month treatment in addition to standard care with a food supplement containing both Curcuma longa and Boswellia serrata extracts on tendinopathy symptoms. Method: This open-label, non-controlled, post-observational study included 670 patients suffering from tendinopathy recr...

journal_title：Current medical research and opinion

authors： Henrotin Y,Dierckxsens Y,Delisse G,Seidel L,Albert A

更新日期：2020-12-21 00:00:00

abstract：AIM:Non-peer-reviewed manuscripts posted as preprints can be cited in peer-reviewed articles, which has both merits and demerits. International Committee of Medical Journal Editors guidelines mandate authors to declare preprints at the time of manuscript submission. We evaluated the trends in pharma-authored research p...

journal_title：Current medical research and opinion

authors： Subramanian K,Nalli A,Senthil V,Bhat A

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Control of arterial hypertension in obese or overweight patients is complicated since obesity directly contributes to increased blood pressure, requiring new, highly effective antihypertensive drugs. This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. METHODS:An internationa...

journal_title：Current medical research and opinion

authors： Chazova IE,Zhernakova YV

更新日期：2020-12-07 00:00:00

abstract：INTRODUCTION:Low adherence and persistence values, which indicate real-life efficiency, have been widely reported in patients suffering from COPD (Chronic Obstructive Pulmonary Disease). Poor adherence may be related to treatment dosage, thus, simplifying the dosing regimen might improve adherence. The objective of the...

journal_title：Current medical research and opinion

authors： Romagnoli A,Santoleri F,Costantini A

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Description of risk of cardiovascular (CV) events associated with diabetes is evolving. This US-based real-world study estimated risk of future CV events and heart failure (HF) from type 2 diabetes (T2DM) only, prior CV events only or T2DM plus prior CV events, versus controls, and evaluated healthcare resou...

journal_title：Current medical research and opinion

authors： Nguyen C,Luthra R,Kuti E,Willey VJ

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Eribulin mesylate (eribulin) is indicated for patients with metastatic breast cancer (MBC) who have previously received at least two chemotherapies in the US and for patients with locally advanced breast cancer (LABC) or MBC who have progressed after at least one chemotherapy in the European Union (EU). In b...

journal_title：Current medical research and opinion

authors： Chabot I,Zhao Q,Su Y

更新日期：2020-12-01 00:00:00

abstract：:The term "mixed pain" is increasingly applied for specific clinical scenarios, such as low back pain, cancer pain and postsurgical pain, in which there "is a complex overlap of the different known pain types (nociceptive, neuropathic, nociplastic) in any combination, acting simultaneously and/or concurrently to cause ...

journal_title：Current medical research and opinion

authors： Freynhagen R,Rey R,Argoff C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive factors associated with physical impairment among older patients with type 2 diabetes mellitus (T2DM) in Japan and to examine the potential impact of physical impairment on patient-reported health outcomes in this population. METHODS:A cross-sectional analysis was conducted usin...

journal_title：Current medical research and opinion

authors： Araki A,Umegaki H,Sakurai T,Mizuno Y,Miyao M,Imori M,Suzuki S,Cambron-Mellott MJ,Yokote K,Onuma T,Yokono K

更新日期：2020-11-23 00:00:00

abstract：INTRODUCTION:Phenylketonuria (PKU) is a rare autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH). Its prevalence is estimated to be 1:10,000 in Europe. PKU is the commonest congenital inborn error of metabolism. The aim of our study was to investigate the characteristics of clinical p...

journal_title：Current medical research and opinion

authors： Burlina A,Leuzzi V,Spada M,Carbone MT,Paci S,Tummolo A

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:There is a general perception that research is underdeveloped in rehabilitation professions. However, a PubMed search found that the growth in publications in the rehabilitation field was twice that of the general medical field. Despite this growth, another study focusing on Europe found that the proportion ...

journal_title：Current medical research and opinion

authors： Decullier E,Tourmente B,Dessez B,Guilhot N,Witko A

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Patients that undergo total hip replacement (THA) are at risk of revision surgery. This study evaluated the cumulative incidence of revision following a medial collared, triple tapered (MCTT) primary hip stem versus other implants in real-world settings using electronic medical records. METHODS:This was a re...

journal_title：Current medical research and opinion

authors： Chitnis AS,Mantel J,Ruppenkamp J,Bourcet A,Holy CE

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We assess the association between TDF exposure and the odds of chronic kidney disease (CKD) and osteoporotic fracture in HIV patients. ...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Hardin JW,Hsu LI,Beaubrun A,Majethia S,Cummings TH

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Migraine is a chronic, disabling neurological disease affecting >1 billion people worldwide. Migraine remains undertreated in Asia, including Taiwan. Galcanezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide, a peptide firmly established in the pathophysiology of m...

journal_title：Current medical research and opinion

authors： Yang CP,Lee CF,Dell'Agnello G,Hundemer HP,Lipsius S,Wang SJ

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To explore the clinical effect and radial remodeling of transradial slender 7 Fr sheath for left main bifurcation disease (LM bifurcation). METHODS:From January 2018 to September 2019, 236 patients with LM bifurcation undergoing transradial percutaneous coronary intervention (PCI) from two heart centers were...

journal_title：Current medical research and opinion

authors： Xu Y,Li Y,Shen H,Zhang B,Zhao Q,Cheng Y,Zhao Z,Guo Q,Yang J,Zhou Y

更新日期：2020-10-01 00:00:00

abstract：:In this narrative review, we will discuss some of the significant risks and dramatic consequences that are associated with epilepsy: depression, suicide, seizure-related injuries, and mortality, both in adults and in children. Considering the high prevalence of depression among people with epilepsy (PWE), routine and ...

journal_title：Current medical research and opinion

authors： Mesraoua B,Deleu D,Hassan AH,Gayane M,Lubna A,Ali MA,Tomson T,Khalil BA,Cross JH,Asadi-Pooya AA

更新日期：2020-09-01 00:00:00

abstract：:Objective: Health utility estimates for children and adolescents are critical for cost-utility analyses informing health technology assessment (HTA) authorities' decisions governing access to pediatric treatments. However, in a recent review, only 29% of published pediatric cost-utility models used a utility measure v...

journal_title：Current medical research and opinion

authors： Bégo-Le Bagousse G,Jia X,Wolowacz S,Eckert L,Tavi J,Hudson R

更新日期：2020-07-01 00:00:00

abstract：:Objective: The aim of this study was to provide recommendations for improving the design of subsequent studies through analysis of the registered coronavirus disease 2019 (COVID-19) clinical trials.Methods: A retrospective analysis of 189 trial retrievals achieved on 20 February 2020.Results: A total of 189 trials are...

journal_title：Current medical research and opinion

authors： Wang B,Lai J,Yan X,Jin F,Yao C

更新日期：2020-07-01 00:00:00

abstract：:Cardiac arrhythmias are the most common cardiac complication reported in pregnant women with and without structural heart disease (SHD); they are more frequent among women with SHD, such as cardiomyopathy and congenital heart disease (CHD). While older studies had indicated supraventricular tachycardia as the most com...

journal_title：Current medical research and opinion

authors： Manolis TA,Manolis AA,Apostolopoulos EJ,Papatheou D,Melita H,Manolis AS

更新日期：2020-07-01 00:00:00

abstract：:Objective: To examine the potential sociodemographic disparities in type 2 diabetes (T2D) management and care among US adult individuals, after controlling for clinical and behavioral factors.Methods: This was a retrospective cohort study of individuals with T2D (N = 4552) from a linked database of the National Health...

journal_title：Current medical research and opinion

authors： Tan X,Lee LK,Huynh S,Pawaskar M,Rajpathak S

更新日期：2020-06-01 00:00:00

abstract：:Objective: This economic evaluation aims to provide a preliminary assessment of the cost-effectiveness of radiofrequency ablation (RFA) compared with argon plasma coagulation (APC) when used to treat APC-refractory gastric antral vascular ectasia (GAVE) in symptomatic patients.Methods: A Markov model was constructed t...

journal_title：Current medical research and opinion

authors： Magee C,Graham D,Leonard C,McMaster J,Davies H,Skotchko M,Lovat L,Murray C,Mealing S,Smart H,Haidry R

更新日期：2020-06-01 00:00:00

abstract：:Objectives: To evaluate central foveal thickness (CFT) variability and accompanying changes in visual acuity (VA) 12 months before and after treatment with the 190 mcg fluocinolone acetonide (FAc) intravitreal implant for diabetic macular edema (DME).Methods: The Iluvien Clinical Evidence cohort study in the United Ki...

journal_title：Current medical research and opinion

authors： Holden SE,Habib M,Currie CJ

更新日期：2020-06-01 00:00:00

abstract：:Objectives: The purpose of this study was to assess (1) the trends of and (2) the factors associated with health information technology (HIT) use among older adults in the U.S.Methods: A decade (2009-2018) of data from the U.S. National Health Interview Survey (NHIS) was used. The trends of HIT use among older adults ...

journal_title：Current medical research and opinion

authors： Hung LY,Lyons JG,Wu CH

更新日期：2020-05-01 00:00:00

abstract：:Aims: We sought to investigate the reasons for, and rates of, novel oral anticoagulant (DOAC) therapy discontinuation.Methods: This was an observational cohort study of patients with atrial fibrillation (AF) referred to a regional DOAC outpatient clinic between February 2013 and October 2017. The study population cons...

journal_title：Current medical research and opinion

authors： Mitrovic D,Folkeringa R,Veeger N,van Roon E

更新日期：2020-04-01 00:00:00

abstract：:Objective: Hypertension is a serious health problem in Egypt, with prevalence rate of 17% as reported in 2015. Despite receiving treatment, many do not achieve blood pressure (BP) control. The current study aimed to evaluate the efficacy and tolerability of amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) singl...

journal_title：Current medical research and opinion

authors： El-Etriby AMK,Rakha S

更新日期：2020-04-01 00:00:00

abstract：:Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited re...

journal_title：Current medical research and opinion

authors： Zakhari A,Sanders AP,Solnik MJ

更新日期：2020-03-01 00:00:00

abstract：:Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...

journal_title：Current medical research and opinion

authors： Edelsberg J,Weycker D,Bensink M,Bowers C,Lyman GH

更新日期：2020-03-01 00:00:00

abstract：:Objective: Global Phase III trials of suvorexant showed no obvious differences in the safety and efficacy profile of suvorexant between elderly and non-elderly patients. However, the clinical profile of suvorexant in elderly patients with comorbidities in a real-world setting was not evaluated. To further understand t...

journal_title：Current medical research and opinion

authors： Takeuchi Y,Sano H,Asai Y,Miyazaki M,Iwakura M,Maeda Y

更新日期：2020-03-01 00:00:00

abstract：:Background: In routine clinical practice, the implantation of a drug-eluting stent (DES) versus a bare metal stent (BMS) for percutaneous coronary intervention (PCI) has been guided by criteria for appropriate use. The cost-effectiveness (CE) of adopting these guidelines, however, is not clear, and was investigated fr...

journal_title：Current medical research and opinion

authors： Ariyaratne TV,Ademi Z,Ofori-Asenso R,Huq MM,Duffy SJ,Yan BP,Ajani AE,Clark DJ,Billah B,Brennan AL,New G,Andrianopoulos N,Reid CM

更新日期：2020-03-01 00:00:00

abstract：:Objective: Type 2 diabetes (T2D) is a prevalent health problem. Oral agents, with the exception of metformin, are often discontinued with the initiation of insulin. The objective was to understand the proportion of patients discontinuing dipeptidyl peptidase-4 inhibitors (DPP-4is) and the reasons for the decision to d...

journal_title：Current medical research and opinion

authors： Fernandes G,Matos JE,Jaffe DH,Beyer G,Yang L,Iglay K,Gantz I,Rajpathak S

更新日期：2020-03-01 00:00:00

abstract：:Critical thinking is crucially important in both research and practice. This article demonstrates that a lack of critical thinking in two meta-analyses resulted in a conclusion that contradicts another meta-analysis and popular opinions. Kahwati et al. and Zhao et al. drew a conclusion that "Vitamin D supplementation ...

journal_title：Current medical research and opinion

authors： Fan H,Xiao J

更新日期：2020-03-01 00:00:00

abstract：:Objective: The purpose of this study was to examine surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (≥80 years of age) who received surgery for gastric cancer.Methods: This study retrospectively reviewed the records of patients ≥65 years old who received a gastrectomy for gastri...

journal_title：Current medical research and opinion

authors： Wong JU,Tai FC,Huang CC

更新日期：2020-02-01 00:00:00

abstract：:Objective: Determine healthcare resource utilization (HCRU) and costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA).Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large US commercia...

journal_title：Current medical research and opinion

authors： Strand V,Shah R,Atzinger C,Zhou J,Clewell J,Ganguli A,Tundia N

更新日期：2020-01-01 00:00:00

abstract：:Objective: To evaluate the safety and efficacy of fulranumab as adjunct or monotherapy in patients with knee or hip pain related to moderate-to-severe osteoarthritis.Methods: Osteoarthritic patients (aged ≥18 years) from four phase 3 randomized, double-blind (DB), placebo-controlled studies were randomized to receive ...

journal_title：Current medical research and opinion

authors： Kelly KM,Sanga P,Zaki N,Wang S,Haeussler J,Louie J,Thipphawong J

更新日期：2019-12-01 00:00:00

abstract：:Objectives: Ethics guidelines such as the Declaration of Helsinki and the CIOMS International Ethical Guidelines for Health-related Research Involving Humans require the sponsors, in cooperation with relevant stakeholders, to provide post-trial access (PTA) to intervention and knowledge, especially in clinical trials ...

journal_title：Current medical research and opinion

authors： Jimenez EB,Virtudazo JMP,Torres CE,Bernabe RD

更新日期：2019-11-01 00:00:00

abstract：:Objective: The aim of this study was to investigate the impact of methodological choices in a meta-analysis of real-world evidence (RWE) comparing three non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists (VKAs) for the treatment of patients with non-valvular atrial fibrillation (NVAF). Methods: Th...

journal_title：Current medical research and opinion

authors： Briere JB,Wu O,Bowrin K,Millier A,Toumi M,Taieb V,Levy P,Coleman CI

更新日期：2019-11-01 00:00:00

abstract：:Objective: To characterize the incidence of select chronic comorbidities in the era of modern (pre-integrase-inhibitor) highly active antiretroviral therapy (HAART) in British Columbia, Canada. Methods: We used data from the Comparative Outcomes And Service Utilization Trends (COAST) study, a population-based cohort s...

journal_title：Current medical research and opinion

authors： Gali B,Eyawo O,Hull MW,Samji H,Zhang W,Sereda P,Lima VD,McGrail K,Montaner JSG,Hogg RS,Moore D,COAST Study Team.

更新日期：2019-11-01 00:00:00

abstract：:Background: Actinic keratosis (AK) is considered an "in situ" non-melanoma skin cancer induced by ultraviolet chronic exposure. Sunscreen and topical anti-inflammatory agents like diclofenac could improve the evolution of this kind of lesions. A topical product containing piroxicam 0.8% and sun filters (50 SPF) (ACTX)...

journal_title：Current medical research and opinion

authors： Agozzino M,Russo T,Franceschini C,Mazzilli S,Garofalo V,Campione E,Bianchi L,Milani M,Argenziano G

更新日期：2019-10-01 00:00:00