听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Current Alzheimer Research期刊下所有文献
  • Alzheimer's Disease and Retinal Degeneration: A Glimpse at Essential Trace Metals in Ocular Fluids and Tissues.

    abstract:BACKGROUND:Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer's Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205016666191023114015

    authors: Micera A,Bruno L,Cacciamani A,Rongioletti M,Squitti R

    更新日期:2019-01-01 00:00:00

  • Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer's Disease.

    abstract:BACKGROUND:Accumulating evidence suggests that multi-target directed ligands have great potential for the treatment of complex diseases such as Alzheimer's Disease (AD). OBJECTIVE:To evaluate novel chimeric 8-hydroxyquinoline ligands with merged pharmacophores as potential multifunctional ligands for AD. METHODS:Nitr...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666191010130351

    authors: Knez D,Sosič I,Pišlar A,Mitrović A,Jukič M,Kos J,Gobec S

    更新日期:2019-01-01 00:00:00

  • Piper sarmentosum Roxb. Root Extracts Confer Neuroprotection by Attenuating Beta Amyloid-Induced Pro-Inflammatory Cytokines Released from Microglial Cells.

    abstract:BACKGROUND:Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that eventually leads to severe cognitive impairment. Although the exact etiologies of AD still remain elusive, increasing evidence suggests that neuroinflammation cascades mediated by microglial cells are associated with AD. Piper sarme...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190228124630

    authors: Chan EWL,Yeo ETY,Wong KWL,See ML,Wong KY,Gan SY

    更新日期:2019-01-01 00:00:00

  • Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.

    abstract:BACKGROUND:The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. OBJECTIVE:This prospective study examined the relationship b...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190805155230

    authors: Eguchi A,Kimura N,Aso Y,Yabuuchi K,Ishibashi M,Hori D,Sasaki Y,Nakamichi A,Uesugi S,Jikumaru M,Sumi K,Shimomura T,Matsubara E

    更新日期:2019-01-01 00:00:00

  • Therapeutic Strategies Targeting Amyloid-β in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and aggregation. AD is pathologically characterized by senile plaques formed by extracellular Amyloid-β (Aβ) peptide and Intracellular Neurofibrillary Tangles (NFT) formed by hyperphosphorylated tau protein. Extensive synaptic loss a...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205016666190321163438

    authors: Pinheiro L,Faustino C

    更新日期:2019-01-01 00:00:00

  • Synthesis of a Novel Curcumin Derivative as a Potential Imaging Probe in Alzheimer's Disease Imaging.

    abstract:BACKGROUND:Curcumin has been of interest in the field of Alzheimer's disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190816130516

    authors: Sturzu A,Sheikh S,Kalbacher H,Nägele T,Weidenmaier C,Wegenast-Braun BM,Schilling N,Ernemann U,Heckl S

    更新日期:2019-01-01 00:00:00

  • Computational and In-Vitro Validation of Natural Molecules as Potential Acetylcholinesterase Inhibitors and Neuroprotective Agents.

    abstract:BACKGROUND:Cholinesterase inhibitors are the first line of therapy for the management of Alzheimer's disease (AD), however, it is now established that they provide only temporary and symptomatic relief, besides, having several inherited side-effects. Therefore, an alternative drug discovery method is used to identify n...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666181212155147

    authors: Kumar A,Mehta V,Raj U,Varadwaj PK,Udayabanu M,Yennamalli RM,Singh TR

    更新日期:2019-01-01 00:00:00

  • High Contrast and Resolution Labeling of Amyloid Plaques in Tissue Sections from APP-PS1 Mice and Humans with Alzheimer's Disease with the Zinc Chelator HQ-O: Practical and Theoretical Considerations.

    abstract:BACKGROUND:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer's disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. However, plaques are known to contain numerous other components, including ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190725155038

    authors: Schmued L,Raymick J,Sarkar S

    更新日期:2019-01-01 00:00:00

  • Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study.

    abstract:BACKGROUND:Determining the underlying etiology of dementia can be challenging. Computer- based Clinical Decision Support Systems (CDSS) have the potential to provide an objective comparison of data and assist clinicians. OBJECTIVES:To assess the diagnostic impact of a CDSS, the PredictND tool, for differential diagnos...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究

    doi:10.2174/1567205016666190103152425

    authors: Bruun M,Frederiksen KS,Rhodius-Meester HFM,Baroni M,Gjerum L,Koikkalainen J,Urhemaa T,Tolonen A,van Gils M,Tong T,Guerrero R,Rueckert D,Dyremose N,Andersen BB,Simonsen AH,Lemstra A,Hallikainen M,Kurl S,Herukka SK,Re

    更新日期:2019-01-01 00:00:00

  • Lead (Pb) in Alzheimer's Dementia: A Systematic Review of Human Case- Control Studies.

    abstract:BACKGROUND:Alzheimer's Dementia (AD) has a complex pathophysiology that is incompletely understood. Chronic, low-level environmental lead (Pb) exposure is associated with cognitive impairment, hypertension and mortality, and has been proposed as a potential cause of AD. OBJECTIVE:We aimed to review the literature to c...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190311101445

    authors: Brown EE,Shah P,Pollock BG,Gerretsen P,Graff-Guerrero A

    更新日期:2019-01-01 00:00:00

  • Longitudinal Neuropsychological Outcome in Taiwanese Alzheimer's Disease Patients Treated with Medication.

    abstract:BACKGROUND:The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as mea...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205014666171010112518

    authors: Yang YH,Wu MN,Chou PS,Su HC,Lin SH,Sung PS

    更新日期:2018-03-14 00:00:00

  • Targeting PPARalpha in Alzheimer's Disease.

    abstract:BACKGROUND:The molecular mechanisms underlying Alzheimer's disease (AD) are yet to be fully elucidated. The so-called "amyloid cascade hypothesis" has long been the prevailing paradigm for causation of disease, and is today being revisited in relation to other pathogenic pathways, such as oxidative stress, neuroinflamm...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205014666170505094549

    authors: D'Orio B,Fracassi A,Ceru MP,Moreno S

    更新日期:2018-02-22 00:00:00

  • Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training.

    abstract:BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666171212103323

    authors: De Marco M,Meneghello F,Pilosio C,Rigon J,Venneri A

    更新日期:2018-01-01 00:00:00

  • Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

    abstract:BACKGROUND:The design of new heterodimeric dual binding site acetylcholinesterase inhibitors constitutes the main goal-directed to the development of new anticholinesterase agents with the expanded pharmacological profile. Multi-target compounds are usually designed by combining in a hybrid molecule with two or more ph...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180711110750

    authors: Hamulakova S,Janovec L,Soukup O,Jun D,Janockova J,Hrabinova M,Sepsova V,Kuca K

    更新日期:2018-01-01 00:00:00

  • Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice.

    abstract:BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to its pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reduci...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180404160625

    authors: Liu SY,Lu S,Yu XL,Yang SG,Liu W,Liu XM,Wang SW,Zhu J,Ji M,Liu DQ,Zhang ZP,Liu RT

    更新日期:2018-01-01 00:00:00

  • Drusen in the Peripheral Retina of the Alzheimer's Eye.

    abstract:BACKGROUND:Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD. OBJECTIVE:This s...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180123122637

    authors: Ukalovic K,Cao S,Lee S,Tang Q,Beg MF,Sarunic MV,Hsiung GR,Mackenzie IR,Hirsch-Reinshagen V,Cui JZ,Matsubara JA

    更新日期:2018-01-01 00:00:00

  • Potential Application of Centrifuges to Protect the CNS in Space and on Earth.

    abstract:OBJECTIVE:Centrifuges are the principal means of generating physiological hypergravity and have been used for many medical purposes, including the therapy of psychiatric diseases and evaluation of vestibular system in the pilots. In particular, modern centrifuges have evolved into mechanically sophisticated precision i...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205015666171229225501

    authors: Hashimoto M,Ho G,Shimizu Y,Sugama S,Takenouchi T,Waragai M,Wei J,Takamatsu Y

    更新日期:2018-01-01 00:00:00

  • The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View.

    abstract::Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids t...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205015666180911151716

    authors: Penke B,Paragi G,Gera J,Berkecz R,Kovács Z,Crul T,VÍgh L

    更新日期:2018-01-01 00:00:00

  • CDK5 and MAPT Gene Expression in Alzheimer's Disease Brain Samples.

    abstract:BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular amyloid plaque and neurofibrillary tangles in the brain. Studies have shown that neurons are able to re-enter the cell cycle, but not enough to enable full replication. This leads to cell death and consequent neurodegener...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205014666170713160407

    authors: Fukasawa JT,de Labio RW,Rasmussen LT,de Oliveira LC,Chen E,Villares J,Tureck G,de Arruda C Smith M,Payao SLM

    更新日期:2018-01-01 00:00:00

  • Transcriptional Remodeling in Primary Hippocampal Astrocytes from an Alzheimer's Disease Mouse Model.

    abstract:BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180613113924

    authors: Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

    更新日期:2018-01-01 00:00:00

  • Acetylcholinesterase Inhibitor Donepezil Effects on Plasma β-Hydroxybutyrate Levels in the Treatment of Alzheimer's Disease.

    abstract:BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a multi-factorial etiology that is not completely understood. Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180601091818

    authors: Wan L,Lu J,Fu J,Huang J,Yang Q,Xin B,Chen L,Huo Y,Zhong Y,Guo C

    更新日期:2018-01-01 00:00:00

  • Ezrin Expression is Increased During Disease Progression in a Tauopathy Mouse Model and Alzheimer's Disease.

    abstract:BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180813152043

    authors: Vega IE,Umstead A,Wygant CM,Beck JS,Counts SE

    更新日期:2018-01-01 00:00:00

  • Voice Markers of Lexical Access in Mild Cognitive Impairment and Alzheimer's Disease.

    abstract:BACKGROUND:Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subt...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205014666170829112439

    authors: Meilan JJG,Martinez-Sanchez F,Carro J,Carcavilla N,Ivanova O

    更新日期:2018-01-01 00:00:00

  • Alzheimer's Disease and NQO1: Is there a Link?

    abstract:BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205014666170203095802

    authors: Chhetri J,King AE,Gueven N

    更新日期:2018-01-01 00:00:00

  • Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study.

    abstract:OBJECTIVE:To study the prevalence of cognitive impairment and dementia in communitydwelling Malays from Singapore; and to examine differences in prevalence among Chinese and Malays. METHODS:Subjects (≥ 60 years) - drawn from the Malay component of the on-going multiethnic Epidemiology of Dementia in Singapore study - ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205012666151002123813

    authors: Hilal S,Tan CS,Xin X,Amin SM,Wong TY,Chen C,Venketasubramanian N,Ikram MK

    更新日期:2017-01-01 00:00:00

  • Potential for Stem Cells Therapy in Alzheimer's Disease: Do Neurotrophic Factors Play Critical Role?

    abstract::Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160314145347

    authors: Bali P,Lahiri DK,Banik A,Nehru B,Anand A

    更新日期:2017-01-01 00:00:00

  • Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A Case Series.

    abstract:OBJECTIVES:REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. Th...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205014666170523094938

    authors: Schaefer C,Kunz D,Bes F

    更新日期:2017-01-01 00:00:00

  • A Multicentre Italian Validation Study in Aging Adults with Down Syndrome and Other Forms of Intellectual Disabilities: Dementia Screening Questionnaire for Individuals with Intellectual Disabilities.

    abstract:BACKGROUND:The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE:In order to meet these ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2174/1567205014666170117094757

    authors: Gomiero T,Bertelli M,Deb S,Weger E,Marangoni A,De Bastiani E,Mantesso U,De Vreese LP

    更新日期:2017-01-01 00:00:00

  • Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

    abstract:BACKGROUND/OBJECTIVES:Increasing evidence suggests the importance of neuroinflammation in the pathogenesis of Alzheimer's disease (AD), which is a complex neurodegenerative disorder. Complement activation occurs in the brain of patients with AD and seems to contribute to an important local inflammatory state. Increased...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205013666161013091934

    authors: Zorzetto M,Datturi F,Divizia L,Pistono C,Campo I,De Silvestri A,Cuccia M,Ricevuti G

    更新日期:2017-01-01 00:00:00

  • The Test Your Memory (TYM) Test Outperforms the MMSE in the Detection of MCI and Dementia.

    abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic accuracy and clinical usability of a Dutch translation of the Test Your Memory (TYM) test in patients with mild cognitive impairment (MCI) and dementia as compared to the Mini-Mental State Examination (MMSE), in the setting of the memory clinic of a general...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205013666161201202520

    authors: van de Zande E,van de Nes JC,Jansen I,van den Berg MN,Zwart AF,Bimmel D,Rijkers GT,Andringa G

    更新日期:2017-01-01 00:00:00

  • AVN-322 is a Safe Orally Bio-Available Potent and Highly Selective Antagonist of 5-HT6R with Demonstrated Ability to Improve Impaired Memory in Animal Models.

    abstract:BACKGROUND:In recent years, 5-hydroxytryptamine subtype 6 receptor (5-HT6 receptor, 5- HT6R) has emerged as a promising therapeutic target for the treatment of neuropathological disorders, including Alzheimer's disease (AD) and schizophrenia. 5-HT6 receptors were hypothesized to be implicated in the processes of learni...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205013666161108105005

    authors: Ivachtchenko AV,Ivanenkov YA,Veselov MS,Okun IM

    更新日期:2017-01-01 00:00:00

  • Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia.

    abstract::In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties tha...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160620114309

    authors: Chiaravalloti A,Danieli R,Lacanfora A,Palumbo B,Caltagirone C,Schillaci O

    更新日期:2017-01-01 00:00:00

  • Omega-3 Fatty Acids: Repurposing Opportunities for Cognition and Biobehavioral Disturbances in MCI and Dementia.

    abstract::Neurodegenerative diseases may directly affect memory performance, thus leading to functional impairments. An increasing body of evidence suggests an association between dietary intake of omega-3 fatty acids and memory functioning in animal models as well as in human studies. Recent evidence supports a potential benef...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160602235520

    authors: Knöchel C,Voss M,Gruter F,Alves GS,Matura S,Sepanski B,Stablein M,Kraft D,Prvulovic D,Carvalho AF,Reif A,Oertel-Knochel V

    更新日期:2017-01-01 00:00:00

  • The Pathophysiology of Heme in the Brain.

    abstract::Heme is essential for the survival of most organisms, despite the fact of being potentially toxic. This dual effect is due to the ability of the iron (Fe) atom contained within the protoporphyrin ring of the heme molecule to participate in redox reactions and exchange electrons with a variety of substrates. Therefore,...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205012666150921103304

    authors: Gozzelino R

    更新日期:2016-01-01 00:00:00

  • Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

    abstract::Down syndrome (DS) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the United States of America. DS is characterized by complete or segmental chromosome 21 trisomy, which leads to variable intellectual disabilities, progressive memory loss, and accelerated neurodegeneratio...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205012666150921095505

    authors: Hamlett ED,Boger HA,Ledreux A,Kelley CM,Mufson EJ,Falangola MF,Guilfoyle DN,Nixon RA,Patterson D,Duval N,Granholm AC

    更新日期:2016-01-01 00:00:00

  • Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease.

    abstract::Pathological remodelling of astroglia represents an important component of the pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and reactivity; which may be specific for different stages of the disease evolution. Astroglial reactivity represents the generic defensive mechanism, and inhib...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666151116130104

    authors: Lim D,Rodríguez-Arellano JJ,Parpura V,Zorec R,Zeidán-Chuliá F,Genazzani AA,Verkhratsky A

    更新日期:2016-01-01 00:00:00

  • Early β-Amyloid-induced Synaptic Dysfunction Is Counteracted by Estrogen in Organotypic Hippocampal Cultures.

    abstract::In the present study we set up a model of slow progression of neuronal injury by exposing organotypic hippocampal cultures to a low concentration of Amyloid β (25-35) peptide (Aβ, 2 μM) to analyze the time-related effects of 17-β estradiol (17β-E2, 10 nM). Neuronal death occurs after 7 d and is prevented by addition o...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205013666160125113509

    authors: Merlo S,Spampinato SF,Capani F,Sortino MA

    更新日期:2016-01-01 00:00:00

  • Neuroprotective Effects of Lithium in Human Brain? Food for Thought.

    abstract:BACKGROUND:There is a growing body of pre-clinical evidence suggesting that lithium (Li) may protect neurons from a range of neurotoxic insults, hence the term neuroprotective effects. Does Li have similar effects also in human subjects? METHODS:We reviewed the neuroimaging literature investigating the association bet...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160219112712

    authors: Hajek T,Weiner MW

    更新日期:2016-01-01 00:00:00

  • Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease.

    abstract::Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid (Aβ) peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS). Trisomy 21 and other forms of aneuploidy also ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720501301151207100616

    authors: Potter H,Granic A,Caneus J

    更新日期:2016-01-01 00:00:00

  • Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease.

    abstract::The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. In the human brain BChE is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition a...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160404120542

    authors: Darvesh S

    更新日期:2016-01-01 00:00:00

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