abstract：:Legionnaire's disease (LD) is most commonly caused by Legionella pneumophila (L. pneumophila). In immunocompromised patients LD can cause necrosis of the lung parenchyma with abscess formation and cavitation. Systemic lupus erythematosus (SLE) is an autoimmune disorder with features of both primary and secondary immun...

journal_title：Lupus

authors： Khokher W,Kesireddy N,Adunse J,Mudiyanselage PH,Iftikhar S,Assaly R

更新日期：2021-01-26 00:00:00

abstract：OBJECTIVES:To compare and rank currently available pharmacological interventions for the prevention of recurrent miscarriage (RM) in women with antiphospholipid syndrome (APS). METHODS:A search was performed using PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, CNKI, ClinicalTrials....

journal_title：Lupus

authors： Yang Z,Shen X,Zhou C,Wang M,Liu Y,Zhou L

更新日期：2021-01-01 00:00:00

abstract：:Numerous drugs have been linked to the induction or exacerbation of systemic cutaneous lupus erythematosus (SCLE). This report presents the third case of the biologic abatacept as an exacerbating medication for SCLE. A 73-year old woman with a remote history of subacute cutaneous lupus and rheumatoid arthritis, well c...

journal_title：Lupus

authors： Figueredo Zamora E,Callen JP,Schadt CR

更新日期：2020-12-22 00:00:00

abstract：OBJECTIVES:To determine the rates of induced abortions in women with systemic lupus erythematosus (SLE) compared to women from the general population and assess disease-related predictors of induced abortion in women with SLE. METHODS:We identified women with SLE (15-45 years) and determined the number of induced abor...

journal_title：Lupus

authors： Venne K,Scott S,Bernatsky S,Vinet E

更新日期：2020-12-15 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can have many cutaneous manifestations including malar rash, discoid rash or oral ulcer. Isolated unilateral involvement of face is uncommon in SLE. It lacks typical clinical features of LE, and may impose a diagnostic challenge for clinicians. H...

journal_title：Lupus

authors： Ha DL,Lee GW,Shin K,Kim HS,Ko HC,Kim BS,Kim MB

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The feed-forward loop of type I interferons (IFNs) production and subsequent immunopathology of systemic lupus erythematosus (SLE) has been hypothesised to be disrupted with inhibition of IFNα or type I IFN receptor subunit 1 (IFNAR). This systematic review and meta-analysis present the treatment efficacy and...

journal_title：Lupus

authors： Koh JWH,Ng CH,Tay SH

更新日期：2020-12-01 00:00:00

abstract：:Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specifi...

journal_title：Lupus

authors： Tandon A,Anupam K,Kaushal J,Gautam P,Sharma A,Bhatnagar A

更新日期：2020-12-01 00:00:00

abstract：:Cardiac involvement in systemic lupus erythematosus (SLE) is well documented. The pericardium, myocardium and endocardium, as well as the coronary arteries, the valves and the conduction system can all be affected. While pericarditis is common, arrythmias are less frequently described.We present a 13-year-old male, wh...

journal_title：Lupus

authors： Fogaça da Mata M,Rebelo M,Sousa HS,Rocha A,Miguel P,Oliveira Ramos F,Costa-Reis P

更新日期：2020-11-20 00:00:00

abstract：INTRODUCTION:Complement activation is central to the pathogenesis of lupus nephritis (LN). Low serum complement C3 and C4, are traditionally used as markers of lupus disease activity in general and LN in particular. In this study we prospectively measured plasma and urine C3d and C4d, degradation products of C3 and C4 ...

journal_title：Lupus

authors： Ganguly S,Majumder S,Kumar S,Gupta R,Muhammed H,Shobha V,Aggarwal A,Misra R

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Since enhanced cardiac magnetic resonance imaging (cMRI) signals have been associated with lupus disease activity in humans prior to renal failure and novel, cardiac-focused therapeutic strategies could be investigated with an associated animal model, autoimmune myocarditis was characterized in murine lupus n...

journal_title：Lupus

authors： Young NA,Jablonski K,Schwarz E,Okafor I,Hampton J,Valiente GR,Henry C,Harb P,Barger J,Bratasz A,Kalyanasundaram A,Ardoin SP,Jarjour WN

更新日期：2020-11-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus (SARS-CoV-2), the virus causing Coronavirus disease 2019 (COVID-19), has had a huge impact on health services with a high mortality associated with complications including pneumonia and acute respiratory distress syndrome. Historical evidence suggests that Lupus patients h...

journal_title：Lupus

authors： Mason A,Rose E,Edwards CJ

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Identifying factors predicting adverse pregnancy outcomes involving systemic lupus erythematosus (SLE) is a research priority. The aims of this study were to investigate (a) the maternal and fetal outcomes of pregnant lupus patients and the factors associated with adverse pregnancy outcomes, and (b) the ef...

journal_title：Lupus

authors： Janardana R,Haridas V,Priya V,Bhat V,Singh Y,Rao VK,Jois R,Srikantiah C,Pinto B,Shobha V

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice in Argentina. METHODS:This retrospective, observational study analysed medical record data of patients with SLE treated with belimumab in 15 centres in Argentina. Primary endpoint: overall clinical r...

journal_title：Lupus

authors： Babini A,Cappuccio AM,Caprarulo C,Casado G,Eimon A,Figueredo H,García MA,Magri S,Mannucci P,Perez Rodriguez S,Pons-Estel BA,Velozo EJ,Iglesias-Rodriguez M,Streger G

更新日期：2020-10-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...

journal_title：Lupus

authors： Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Sexual dysfunction in systemic lupus erythematous (SLE) patients is an important issue to be tackled. We aimed to study the prevalence of sexual dysfunction in SLE women and detect its association with depression, functional disability and quality of life. METHODS:This study included 94 SLE females. Ninety-...

journal_title：Lupus

authors： Dorgham D,Haggag HM,Attia DH

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to clarify the activation of complement pathways in patients with lupus nephritis (LN), and to elucidate the association between these complement activation types and clinical outcomes. METHODS:We enrolled 115 patients with biopsy-proven LN from 2003 to 2016 from the lupus cohort...

journal_title：Lupus

authors： Kim H,Kim T,Kim M,Lee HY,Kim Y,Kang MS,Kim J

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS:This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic I...

journal_title：Lupus

authors： Bearne LM,Bieles J,Georgopoulou S,Andrews J,Tully A,Stolarchuk-Prowting K,Williamson T,Suarez BS,Nel L,D'Cruz D,Lempp H

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can involve multiple organ systems. Exposure to ultraviolet radiation (UVR) can exacerbate pre-existing SLE, and can even induce systemic manifestations. This study aimed to investigate the photoprotective habits of children with SLE and...

journal_title：Lupus

authors： Janthongsri T,Wisuthsarewong W,Nitiyarom R

更新日期：2020-07-01 00:00:00

abstract：:Mesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex-histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this...

journal_title：Lupus

authors： Liu F,Chen H,Chen T,Lau CS,Yu FX,Chen K,Chen HP,Pan RS,Chan GC,Zhang XY,Nie YJ

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS:We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within...

journal_title：Lupus

authors： Wu MC,Huang JY,Chen HH,Wei JC

更新日期：2020-06-01 00:00:00

abstract：Background:Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Tha...

journal_title：Lupus

authors： Juthong S,Geater AF,Dekumyoy P,Hortiwakul T,Siripaitoon B,Aiewruengsurat D,Thongbun N

更新日期：2020-05-01 00:00:00

abstract：:Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...

journal_title：Lupus

authors： Zhang XD,Zhao LR,Zhou JM,Su YY,Ke J,Cheng Y,Li JL,Shen W

更新日期：2020-04-01 00:00:00

abstract：:Associations of polymorphisms in vitamin D receptor (VDR) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have already been explored by many studies. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR and RA/SLE by combing the results of all relevant stu...

journal_title：Lupus

authors： Zhang WT,Jin TF,Chen L

更新日期：2020-04-01 00:00:00

abstract：:We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...

journal_title：Lupus

authors： Cicarini WB,Duarte RCF,Ferreira KS,Loures CMG,Consoli RV,Neiva CLS,de Pádua PM,Nunes FFC,Alves LCV,Reis EA,Moreira CC,Guimarães TMPD,de Toledo VPCP,Carvalho MDG

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...

journal_title：Lupus

authors： Xu D,Zhao S,Li Q,Wang YH,Zhao JL,Li MT,Zhao Y,Zeng XF

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is regarded as a prototype autoimmune disease because it can serve as a means for studying differences between ethnic minorities and sex. Traditionally, all Hispanics have been bracketed within the same ethnic group, but there are differences between Hispanics from Spain an...

journal_title：Lupus

authors： Hernández Cruz B,Alonso F,Calvo Alén J,Pego-Reigosa JM,López-Longo FJ,Galindo-Izquierdo M,Olivé A,Tomero E,Horcada L,Uriarte E,Erausquin C,Sánchez-Atrio A,Montilla C,Santos Soler G,Fernández-Nebro A,Blanco R,Rodríguez-Góm

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The heterogeneous spectrum of systemic lupus erythematosus (SLE) often presents with secondary complications such as cardiovascular disease (CVD), infections and neoplasms. Our study assessed whether the presence of SLE independently increases or reduces the disparities, accounting for the already higher risk...

journal_title：Lupus

authors： Falasinnu T,Chaichian Y,Li J,Chung S,Waitzfelder BE,Fortmann SP,Palaniappan L,Simard JF

更新日期：2019-12-01 00:00:00

abstract：:Platelet activation and decrease in platelet count characterize the development of the most feared form of antiphospholipid syndrome (APS), i.e. catastrophic APS (CAPS). We aimed to assess if immuno-affinity purified anti-β2-glycoprotein I (aβ2GPI) antibodies enhance platelet activation inducing a significant flow obs...

journal_title：Lupus

authors： Pontara E,Cheng C,Cattini MG,Bison E,Pelloso M,Denas G,Pengo V

更新日期：2019-12-01 00:00:00

abstract：:With an increasing number of international journeys occurring daily, there is also an increase in the need for appropriate medical advice for patients who will undertake such travel. In this context, the lupus patient presents a great challenge to the rheumatologist. However, the demand for such information by patient...

journal_title：Lupus

authors： Oliveira DS,Hillal JPD,Cordova DDP,de Araujo DB

更新日期：2019-12-01 00:00:00

abstract：:Prognosis of pregnancies in women with antiphospholipid syndrome has dramatically improved over the past two decades using conventional treatment with low molecular weight heparin and low-dose aspirin. However, despite this regimen, 10-15% of antiphospholipid syndrome patients experience pregnancy losses. Several stud...

journal_title：Lupus

authors： Tabacco S,Giannini A,Garufi C,Botta A,Salvi S,Del Sordo G,Benedetti Panici P,Lanzone A,De Carolis S

更新日期：2019-11-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a suggested genetic basis. The newly identified human programmed cell death 1 gene could be associated with SLE susceptibility. We aimed to investigate the association between programmed cell death 1 polymorphism (PD1.3G/A (rs11568821) and PD1...

journal_title：Lupus

authors： Abo El-Khair SM,Sameer W,Awadallah N,Shaalan D

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...

journal_title：Lupus

authors： Oliveira-Santos M,Verani JFS,Camacho LAB,de Andrade CAF,Klumb EM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility. METHODS:A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms an...

journal_title：Lupus

authors： Wang JM,Yuan ZC,Huang AF,Xu WD

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to analyse autoantibodies' titres modulation during belimumab treatment in 50 patients with systemic lupus erythematosus (SLE). METHODS:Sera were collected at belimumab start (T0) and every six months until the 24th month. Disease activity index (SLEDAI-2K) was analysed at eve...

journal_title：Lupus

authors： Cavazzana I,Kumar R,Pozzari C,Ottaviani R,Fredi M,Piantoni S,Andreoli L,Tincani A,Franceschini F

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...

journal_title：Lupus

authors： Jia J,Xie J,Li H,Wei H,Li X,Hu J,Meng D,Zhang Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. OBJECTIVES:The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions -986 (G/A), -602 (G/A), ...

journal_title：Lupus

authors： Elkoumi MA,Emam AA,Allah MAN,Sherif AH,Abdelaal NM,Mosabah A,Zakaria MT,Soliman MM,Salah A,Sedky YM,Mashali MH,Elashkar SSA,Hafez SFM,Hashem MIA,Elshreif AM,Youssef M,Fahmy DS,Sallam MM,Nawara AM,Elgohary EA,Ahmed

更新日期：2019-07-01 00:00:00

abstract：:Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had...

journal_title：Lupus

authors： Plana-Pla A,Bielsa Marsol I,Ferrandiz Foraster C

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a chronic, multisystemic, immune-mediated disorder associated with a substantial hospitalization risk. As a comparatively rare disease, there is a sparsity of research examining the burden of hospital admission in the contemporary era. We aim to describe national trends ...

journal_title：Lupus

authors： Hannah J,Galloway J,Kaul A

更新日期：2019-06-01 00:00:00