abstract：INTRODUCTION:Chronic abruption oligohydramnios sequence (CAOS) is histologically characterized by diffuse chorioamniotic hemosiderosis (DCH). However, the criteria for the histological evaluation of the extent of CAOS-related hemosiderin deposition (HD) of the membranes and the difference in HD between the chorionic pl...

journal_title：Placenta

authors： Ishida A,Minamiguchi S,Yamada Y,Nakagawa R,Chigusa Y,Kondoh E,Mandai M,Haga H

更新日期：2021-01-20 00:00:00

abstract：INTRODUCTION:Preeclampsia is one of the main causes of morbidity and mortality in pregnant women and mothers. Numerous studies showed that microRNAs (miRNAs) played important roles in the occurrence and development of preeclampsia. However, the regulation of microRNA-142-3p (miR-142-3p) in preeclampsia has not been cla...

journal_title：Placenta

authors： Mao Y,Hou B,Shan L,Sun X,Wang L

更新日期：2021-01-06 00:00:00

abstract：INTRODUCTION:Air pollution has significant negative health impacts, particularly on the cardiovascular system. The aims of this narrative review were to identify whether there is an association between air pollution and the incidence of pre-eclampsia, and the potential mechanisms by which any effects may be mediated. ...

journal_title：Placenta

authors： Bearblock E,Aiken CE,Burton GJ

更新日期：2020-12-18 00:00:00

abstract：INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...

journal_title：Placenta

authors： Ho A,Hutter J,Slator P,Jackson L,Seed PT,Mccabe L,Al-Adnani M,Marnerides A,George S,Story L,Hajnal JV,Rutherford M,Chappell LC

更新日期：2020-12-13 00:00:00

abstract：:Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imagin...

journal_title：Placenta

authors： Lewis RM,Pearson-Farr JE

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

journal_title：Placenta

authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

更新日期：2020-11-14 00:00:00

abstract：:Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...

journal_title：Placenta

authors： Lopez-Tello J,Sferruzzi-Perri AN

更新日期：2020-11-02 00:00:00

abstract：:Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...

journal_title：Placenta

authors： Ying X,Zhu Y,Jin X,Chang X

更新日期：2020-10-20 00:00:00

abstract：:Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...

journal_title：Placenta

authors： Mantri S,Sheikali A,Binns C,Lyell DJ,DiGiusto DL,Porteus MH,Agarwal-Hashmi R

更新日期：2020-10-13 00:00:00

abstract：INTRODUCTION:Knockout mouse model has shown a relationship between Slit2/Robo1 signalling and altered fertility. Altered expression by endometrial epithelium and trophoblast and is associated with the pathogenesis of pregnancy complications but few studies have investigated the expression of decidual Slit2 in miscarria...

journal_title：Placenta

authors： Chen J,Liu J,Gao S,Qiu Y,Wang Y,Zhang Y,Gao L,Qi G,Wu Y,Lash GE,Li P

更新日期：2020-10-09 00:00:00

abstract：INTRODUCTION:The limited cell number of primary trophoblasts and contamination of trophoblast cell lines promote us to develop a novel stable trophoblast cell line. METHOD OF STUDY:Primary trophoblast cells were isolated from first-trimester placenta and telomerase-induced immortalization was used to immortalize these...

journal_title：Placenta

authors： Liu H,Wang L,Wang Y,Zhu Q,Aldo P,Ding J,Mor G,Liao A

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Maternal risk factors associated with placenta previa are well documented in the literature. However, there are limited studies identifying maternal characteristics associated with the persistence of placenta previa. The objective of the study was to determine maternal characteristics associated with the p...

journal_title：Placenta

authors： King LJ,Dhanya Mackeen A,Nordberg C,Paglia MJ

更新日期：2020-09-15 00:00:00

abstract：:Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (...

journal_title：Placenta

authors： Thoene M,Van Ormer M,Yuil-Valdes A,Bruett T,Natarajan SK,Mukherjee M,Thompson M,Nordgren TM,Van Lippevelde W,Overby NC,Adu-Bonsaffoh K,Anderson-Berry A,Hanson C

更新日期：2020-09-01 00:00:00

abstract：:Based on a variety of tissue samples, including Caesarean hysterectomy specimens with the placenta in situ, a detailed map of uteroplacental vascular lesions was established in over a century of research. One such lesion is acute atherosis of unremodelled basal and uteroplacental arteries, defined by the presence of f...

journal_title：Placenta

authors： Brosens I,Brosens JJ,Muter J,Benagiano G

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....

journal_title：Placenta

authors： Morosin SK,Delforce SJ,Lumbers ER,Pringle KG

更新日期：2020-08-01 00:00:00

abstract：:The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclamp...

journal_title：Placenta

authors： Rani A,Chavan-Gautam P,Mehendale S,Wagh G,Mani NS,Joshi S

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...

journal_title：Placenta

authors： Piñuñuri R,Castaño-Moreno E,Llanos MN,Ronco AM

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Preeclampsia (PE) is one of the leading causes of maternal mortality and morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has been a focus of research. This study was to identified genes or pathways that may be associated with PE, and discuss whether the changes in the me...

journal_title：Placenta

authors： Li Y,Cui S,Shi W,Yang B,Yuan Y,Yan S,Li Y,Xu Y,Zhang Z,Linlin Zhang

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. METHODS:In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler u...

journal_title：Placenta

authors： Alanne L,Bhide A,Hoffren J,Lantto J,Huhta H,Kokki M,Haapsamo M,Acharya G,Räsänen J

更新日期：2020-01-15 00:00:00

abstract：:The umbilical cord (UC) connects the fetal blood supply to the placenta, so is exposed to all systemic endo- and xenobiotics. We have extensive experience using UC as an analytical matrix for detecting and/or quantitating drugs, chemicals and endogenous compounds. This technical note describes advantages (large amount...

journal_title：Placenta

authors： Price HR,Chehroudi C,Knight SJ,Smith AD,Lai D,Kim H,Wright TE,Coughtrie MW,Collier AC

更新日期：2020-01-15 00:00:00

abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...

journal_title：Placenta

authors： Lei D,Deng N,Wang S,Huang J,Fan C

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

journal_title：Placenta

authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Preterm birth is a heterogeneous phenotype, with placental abnormalities underlying many cases. The etiology of preterm births that occur in the absence of placental abnormalities, however, remain enigmatic and we considered that early pregnancy biomarkers may provide clues. METHODS:Women from a hospital-...

journal_title：Placenta

authors： Sun B,Parks WT,Simhan HN,Bertolet M,Catov JM

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...

journal_title：Placenta

authors： Koppes E,Shaffer B,Sadovsky E,Himes K,Barak Y,Sadovsky Y,Chaillet JR

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Pregestational maternal obesity (PGMO) associates with foetoplacental vascular endothelial dysfunction and higher risk for insulin resistance in the neonate. We characterised the PGMO consequences on the insulin response of the human foetoplacental vasculature. METHODS:Umbilical veins were from pregnancies w...

journal_title：Placenta

authors： Villalobos-Labra R,Westermeier F,Pizarro C,Sáez PJ,Toledo F,Pardo F,Kusanovic JP,Mardones F,Poblete JA,Sobrevia L,Farías M

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Placental abruption is a serious pregnancy complication that causes maternal and neonatal mortality and morbidity. Whether maternal and neonatal outcomes differ between patients who concurrently presented with preeclampsia and those who did not, have not been fully investigated. METHODS:A total number of ...

journal_title：Placenta

authors： Han M,Liu D,Zeb S,Li C,Tong M,Li X,Chen Q

更新日期：2019-09-15 00:00:00

abstract：INTRODUCTION:Placenta previa is a severe pregnancy complication with considerable maternal and neonatal morbidity. Placenta previa can be defined as major or minor by location. Major placenta previa is associated with higher complication rates. Management of women with minor placenta previa has not been well defined. T...

journal_title：Placenta

authors： Grönvall M,Stefanovic V,Paavonen J,Loukovaara M,Tikkanen M

更新日期：2019-09-15 00:00:00

abstract：:The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...

journal_title：Placenta

authors： Rhon-Calderon EA,Vrooman LA,Riesche L,Bartolomei MS

更新日期：2019-09-01 00:00:00

abstract：:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....

journal_title：Placenta

authors： Umezawa A,Hasegawa A,Inoue M,Tanuma-Takahashi A,Kajiwara K,Makino H,Chikazawa E,Okamoto A

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...

journal_title：Placenta

authors： Xu T,Zhou Z,Liu N,Deng C,Huang G,Zhou F,Liu X,Wang X

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...

journal_title：Placenta

authors： Tol ID,Yousif M,Collins SL

更新日期：2019-06-01 00:00:00

abstract：:Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations w...

journal_title：Placenta

authors： Oktavianthi S,Fauzi M,Trianty L,Trimarsanto H,Bowolaksono A,Noviyanti R,Malik SG

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways. METHODS:Rats were fed a normal o...

journal_title：Placenta

authors： Lin YJ,Huang LT,Tsai CC,Sheen JM,Tiao MM,Yu HR,Lin IC,Tain YL

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Visualization of the retroplacental clear space (RPCS) may provide critical insight into the development of abnormally invasive placenta (AIP). In this pre-clinical study, we characterized the appearance of the RPCS on magnetic resonance imaging (MRI) during the second half of gestation using a liposomal g...

journal_title：Placenta

authors： Badachhape AA,Kumar A,Ghaghada KB,Stupin IV,Srivastava M,Devkota L,Starosolski Z,Tanifum EA,George V,Fox KA,Yallampalli C,Annapragada AV

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Chromatin alterations are important mediators of gene expression changes. We have recently shown that activated non-canonical NF-κB signaling (RelB/p52) recruits histone acetyltransferase CBP and deacetylase HDAC1 to selectively acetylate H3K9 (H3K9ac) to induce expression of corticotropin-releasing hormone ...

journal_title：Placenta

authors： Wang B,Wang P,Parobchak N,Treff N,Tao X,Wang J,Rosen T

更新日期：2019-01-15 00:00:00

abstract：INTRODUCTION:To compare the intertwin umbilical cord coiling in twin-twin transfusion syndrome (TTTS) before fetoscopic laser treatment and to correlate these with Doppler findings in both twins. METHODS:We performed a prospective study using three-dimensional (3D) ultrasound with color Doppler imaging of the umbilica...

journal_title：Placenta

authors： Bamberg C,Diemert A,Glosemeyer P,Tavares de Sousa M,Hecher K

更新日期：2019-01-15 00:00:00

abstract：INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...

journal_title：Placenta

authors： Tsur A,Kalish F,Burgess J,Nayak NR,Zhao H,Casey KM,Druzin ML,Wong RJ,Stevenson DK

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Women with adverse pregnancy outcomes (APOs) have excess risk of later life cardiovascular disease (CVD) perhaps related to an underlying high-risk vascular phenotype. We sought to determine if placental evidence of maternal malperfusion in uncomplicated pregnancies is associated with an increased risk of ...

journal_title：Placenta

authors： Hauspurg A,Redman EK,Assibey-Mensah V,Tony Parks W,Jeyabalan A,Roberts JM,Catov JM

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:The human placenta extrudes a variety of extracellular vesicles (EVs) into the maternal blood daily. These vesicles may be crucial to the adaptation of the maternal cardiovascular and immune systems to pregnancy. Quantifying the EVs that are released in early gestation is important to our understanding of ho...

journal_title：Placenta

authors： Liu H,Kang M,Wang J,Blenkiron C,Lee A,Wise M,Chamley L,Chen Q

更新日期：2018-12-01 00:00:00

abstract：:As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are lik...

journal_title：Placenta

authors： Hill DJ

更新日期：2018-09-01 00:00:00