当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.

Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.

Abstract：

INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a partial HO-1 deficiency. METHODS:At E14.5, untreated pregnant wild-type (WT, n=13-18), untreated HO-1+/- (Het, n=6-9), and Het mice treated with pravastatin (Het+Pravastatin, n=12-14) were sacrificed. Numbers of viable fetuses/resorbed concepti were recorded. Maternal livers and placentas were harvested for HO activity. Hematoxylin and eosin (H&E) and CD31 immunohistochemical staining were performed on whole placentas. RESULTS:Compared with WT, HO activity in Het livers (65±18%, P<0.001) and placentas (74±7%, P<0.001) were significantly decreased. Number of viable fetuses per dam was significantly lower in Untreated Het dams (6.0±2.2) compared with WT (9.1±1.4, P<0.01), accompanied by a higher relative risk (RR) for concepti resorption (17.1, 95% CI 4.0-73.2). In Hets treated with pravastatin, maternal liver and placental HO activity increased, approaching levels of WT controls (to 83±7% and 87±14%, respectively). The number of viable fetuses per dam increased to 7.7±2.5 with a decreased RR for concepti resorption (2.7, 95% CI 1.2-5.9). In some surviving Untreated Het placentas, there were focal losses of cellular architecture and changes suggestive of reduced blood flow in the labyrinth. These findings were absent in Het+Pravastatin placentas. DISCUSSION:Pravastatin induces maternal liver and placental HO activity, may affect placental function and improve fetal survival in the context of a partial deficiency of HO-1.

journal_name

Placenta

journal_title

Placenta

authors

Tsur A,Kalish F,Burgess J,Nayak NR,Zhao H,Casey KM,Druzin ML,Wong RJ,Stevenson DK

doi

10.1016/j.placenta.2018.11.001

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1-8

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(18)30657-X

journal_volume

75

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Gross abnormalities of the umbilical cord: related placental histology and clinical significance.

    abstract：OBJECTIVE:To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta. METHODS:Placental slides of 224 singleton pregnancies with gross cord abnormality (true knots, long cord...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.09.005

    authors： Tantbirojn P,Saleemuddin A,Sirois K,Crum CP,Boyd TK,Tworoger S,Parast MM

    更新日期：2009-12-01 00:00:00

  • Establishment and characterization of a new human first trimester Trophoblast cell line, AL07.

    abstract：INTRODUCTION:The limited cell number of primary trophoblasts and contamination of trophoblast cell lines promote us to develop a novel stable trophoblast cell line. METHOD OF STUDY:Primary trophoblast cells were isolated from first-trimester placenta and telomerase-induced immortalization was used to immortalize these...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.08.013

    authors： Liu H,Wang L,Wang Y,Zhu Q,Aldo P,Ding J,Mor G,Liao A

    更新日期：2020-10-01 00:00:00

  • Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes.

    abstract：:Human endothelial dysfunction is a common feature in many diseases of pregnancy, such as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide (NO) and abnormal membrane transport of l-arginine and adenosine in primary cultures of human umbilical vein (HUVEC, macrovascular) and placen...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2010.12.011

    authors： Sobrevia L,Abarzúa F,Nien JK,Salomón C,Westermeier F,Puebla C,Cifuentes F,Guzmán-Gutiérrez E,Leiva A,Casanello P

    更新日期：2011-03-01 00:00:00

  • The evolving placenta: convergent evolution of variations in the endotheliochorial relationship.

    abstract：:Endotheliochorial placentas occur in orders from all four major clades of eutherian mammal. Species with this type of placenta include one of the smallest (pygmy shrew) and largest (African elephant) land mammals. The endotheliochorial placenta as a definitive form has an interhemal area consisting of maternal endothe...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2012.02.008

    authors： Enders AC,Carter AM

    更新日期：2012-05-01 00:00:00

  • Vasoactive effects of 8-epi-prostaglandin F(2alpha)in isolated human placental conduit and resistance blood vessels in vitro.

    abstract：:The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0690

    authors： Kwek K,Read MA,Khong TY,Bisits AT,Walters WA

    更新日期：2001-07-01 00:00:00

  • Corticotrophin-releasing hormone production by the placenta and fetal membranes.

    abstract：:Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence d...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/0143-4004(91)90015-8

    authors： Riley SC,Challis JR

    更新日期：1991-03-01 00:00:00

  • Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review.

    abstract：:The central role of the placenta in the pathogenesis of pre-eclampsia is undisputed. The evidence that maternal syndrome of pre-eclampsia is caused by a maternal systemic inflammatory response (MSIR) is reviewed. The polymorphic nature of the inflammatory network explains the diversity of the varied signs of this cond...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1053/plac.2002.0930

    authors： Redman CW,Sargent IL

    更新日期：2003-04-01 00:00:00

  • Oestrogen and progesterone receptors in human term placenta. Measurement by binding assays and immunological methods.

    abstract：:Oestrogen and progesterone receptors have been implicated in human placental steroidogenesis, but studies developed to measure their concentration in this tissue at term yielded discrepant results. Potential inaccuracy of the binding assays, the technique used in previous studies, might influence the discrepancy. In t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(89)90049-0

    authors： Rivera J,Cano A

    更新日期：1989-11-01 00:00:00

  • Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels.

    abstract：:Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was tha...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)90002-9

    authors： Luckas MJ,Sandland R,Hawe J,Neilson JP,McFadyen IR,Meekins JW

    更新日期：1998-03-01 00:00:00

  • Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing.

    abstract：INTRODUCTION:Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways. METHODS:Rats were fed a normal o...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.03.004

    authors： Lin YJ,Huang LT,Tsai CC,Sheen JM,Tiao MM,Yu HR,Lin IC,Tain YL

    更新日期：2019-03-01 00:00:00

  • The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction.

    abstract：:The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.04.003

    authors： Finn-Sell SL,Renshall LJ,Cowley EJ,Dilworth MR,Wareing M,Greenwood SL,Sibley CP,Cottrell EC

    更新日期：2016-06-01 00:00:00

  • Transcriptional profiling with a pathway-oriented analysis in the placental villi of unexplained miscarriage.

    abstract：INTRODUCTION:Miscarriage is the most common placental-related complication of pregnancy. It has been extensively investigated to discover the underlying mechanism(s) by which miscarriage occurs, but in many cases the etiology still remains unclear. The aim of this study was to analyze genome-wide expression profiles of...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.12.003

    authors： Lyu SW,Song H,Yoon JA,Chin MU,Sung SR,Kim YS,Lee WS,Yoon TK,Cha DH,Shim SH

    更新日期：2013-02-01 00:00:00

  • Confocal and conventional immunofluorescent and immunogold electron microscopic localization of collagen types III and IV in human placenta.

    abstract：:Confocal and conventional indirect immunofluorescence and immunogold electron microscopic methods were applied to examine the distribution of extracellular matrix constituents (collagens types III and IV) in the villi of immature and term human placentae. The immunofluorescence study revealed that collagen type III is...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(91)90493-y

    authors： Nanaev AK,Rukosuev VS,Shirinsky VP,Milovanov AP,Domogatsky SP,Duance VC,Bradbury FM,Yarrow P,Gardiner L,d'Lacey C

    更新日期：1991-11-01 00:00:00

  • Effects of nitrovasodilators on the human fetal-placental circulation in vitro.

    abstract：:This study examines the vasorelaxation of isolated human placental chorionic plate arteries and the perfused fetal-placental vasculature, in vitro, to a variety of nitrovasodilator compounds including glyceryl trinitrate (GTN) sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP), S-nitroso-N-glutathione ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0625

    authors： Zhang XQ,Kwek K,Read MA,Donoghue JF,Walters WA

    更新日期：2001-04-01 00:00:00

  • Fractional volume of placental vessels in women with diabetes using a novel stereological 3D power Doppler technique.

    abstract：OBJECTIVES:In maternal diabetes the placenta is large with abnormal vascular development and increased villous volume. We used a novel stereological 3D power Doppler ultrasound technique to investigate differences in-vivo in the placental fractional volume of power Doppler signal (FrVol-PD) between women with and witho...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.08.015

    authors： Jones NW,Deshpande R,Mousa HA,Mansell P,Raine-Fenning N,Bugg G

    更新日期：2013-11-01 00:00:00

  • Leptin reduces apoptosis triggered by high temperature in human placental villous explants: The role of the p53 pathway.

    abstract：:Maternal fever is common during pregnancy and has for many years been suspected to harm the developing fetus. Whether increased maternal temperature produces exaggerated apoptosis in trophoblast cells remains unclear. Since p53 is a critical regulator of apoptosis we hypothesized that increased temperature in placenta...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.03.009

    authors： Pérez-Pérez A,Toro AR,Vilarino-Garcia T,Guadix P,Maymó JL,Dueñas JL,Varone CL,Sánchez-Margalet V

    更新日期：2016-06-01 00:00:00

  • Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts.

    abstract：:Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0774

    authors： Udagawa K,Yasumitsu H,Esaki M,Sawada H,Nagashima Y,Aoki I,Jin M,Miyagi E,Nakazawa T,Hirahara F,Miyazaki K,Miyagi Y

    更新日期：2002-02-01 00:00:00

  • Comparative study of regenerative effects of mesenchymal stem cells derived from placental amnion, chorion and umbilical cord on dermal wounds.

    abstract：OBJECTIVE:Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorioni...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2018.04.004

    authors： Ertl J,Pichlsberger M,Tuca AC,Wurzer P,Fuchs J,Geyer SH,Maurer-Gesek B,Weninger WJ,Pfeiffer D,Bubalo V,Parvizi D,Kamolz LP,Lang I

    更新日期：2018-05-01 00:00:00

  • Fibulin-5 is upregulated in decidualized human endometrial stromal cells and promotes primary human extravillous trophoblast outgrowth.

    abstract：:Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.10.008

    authors： Winship A,Cuman C,Rainczuk K,Dimitriadis E

    更新日期：2015-12-01 00:00:00

  • Isolation of phenotypically distinct trophoblast cell lines from normal rat chorioallantoic placentas.

    abstract：:Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(89)90038-6

    authors： Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

    更新日期：1989-03-01 00:00:00

  • Effect of heme oxygenase-1 deficiency on placental development.

    abstract：:Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been associated with pregnancy disorders, such as recurrent miscarriages, intrauterine growth retardation, and pre-eclampsia. The aim of this study was t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.07.012

    authors： Zhao H,Wong RJ,Kalish FS,Nayak NR,Stevenson DK

    更新日期：2009-10-01 00:00:00

  • Growth restricting effects of a single course of antenatal betamethasone treatment and the role of human placental lactogen.

    abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.02.002

    authors： Braun T,Husar A,Challis JR,Dudenhausen JW,Henrich W,Plagemann A,Sloboda DM

    更新日期：2013-05-01 00:00:00

  • Pregnancy outcomes and ultrasonographic diagnosis in patients with histologically-proven placental chorioangioma.

    abstract：OBJECTIVE:To evaluate pregnancy outcome and ultrasound diagnosis in patients with histologically-confirmed placental chorioangioma. STUDY DESIGN:Placentas with histological diagnosis of chorioangioma were identified and medical charts were reviewed for findings of ultrasound examinations. Pregnancy outcomes were compa...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.06.007

    authors： Wou K,Chen MF,Mallozzi A,Brown RN,Shrim A

    更新日期：2011-09-01 00:00:00

  • Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

    abstract：:The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investig...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.04.018

    authors： Herr F,Schreiner I,Baal N,Pfarrer C,Zygmunt M

    更新日期：2011-08-01 00:00:00

  • Fused placentas: Till birth do us part.

    abstract：:Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.10.036

    authors： Lopez-Tello J,Sferruzzi-Perri AN

    更新日期：2020-11-02 00:00:00

  • Autophagy in placentas from acidotic newborns: an immunohistochemical study of LC3 expression.

    abstract：:Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining wit...

    journal_title：Placenta

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.placenta.2013.09.004

    authors： Avagliano L,Danti L,Doi P,Felis S,Guala M,Locatelli A,Maffeo I,Mecacci F,Plevani C,Simeone S,Bulfamante GP

    更新日期：2013-11-01 00:00:00

  • Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed.

    abstract：BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.02.001

    authors： Moon KC,Park JS,Norwitz ER,Kim DI,Oh KJ,Park CW,Jun JK,Syn HC

    更新日期：2008-05-01 00:00:00

  • Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia.

    abstract：:The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclamp...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.04.013

    authors： Rani A,Chavan-Gautam P,Mehendale S,Wagh G,Mani NS,Joshi S

    更新日期：2020-06-01 00:00:00

  • Downregulation of HLA class I gene transcription in choriocarcinoma cells is controlled by the proximal promoter element and can be reversed by CIITA.

    abstract：:The expression pattern of MHC class I genes in trophoblast cells at the feto-maternal interface is thought to be the basis of the maintenance of pregnancy by protecting the fetus from maternal immune rejection. Transcription of classical HLA class I genes is low or undetectable in most trophoblast cells as well as in ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1998.0380

    authors： Lefebvre S,Moreau P,Dausset J,Carosella ED,Paul P

    更新日期：1999-05-01 00:00:00

  • Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture: A time-lapse study.

    abstract：INTRODUCTION:To elucidate whether trophoblast expansion and invasion are modulated by androgen signaling in an in vitro co-culture model system with decidualizing endometrial stromal cells (ESCs). METHODS:We employed an in vitro co-culture model of early embryo implantation, consisting of human ESCs (EtsT499 cells) an...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.09.005

    authors： Wongwananuruk T,Sato T,Kajihara T,Matsumoto S,Akita M,Tamura K,Brosens JJ,Ishihara O

    更新日期：2016-11-01 00:00:00