Abstract:
:Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence demonstrating that glucocorticoids stimulate the production of CRH by these tissues towards term, and this is manifest by increases in CRH concentrations in maternal and fetal plasma and in placental extracts, and by increased abundance of CRH mRNA in the placenta. We discuss how CRH secretion by the placenta and fetal membranes is controlled. We hypothesize that CRH may be an important signal in initiating of the onset and maintenance of term labour and may also be a factor in the etiology of premature labour, through stimulation of the fetal HPA axis, and through paracrine/autocrine interactions within the placenta, fetal membranes and decidua.
journal_name
Placentajournal_title
Placentaauthors
Riley SC,Challis JRdoi
10.1016/0143-4004(91)90015-8subject
Has Abstractpub_date
1991-03-01 00:00:00pages
105-19issue
2eissn
0143-4004issn
1532-3102pii
0143-4004(91)90015-8journal_volume
12pub_type
杂志文章,评审相关文献
PLACENTA文献大全abstract::During pregnancy, leptin concentrations in the maternal circulation are elevated in both humans and rodents but decrease to pre-pregnancy levels at birth, suggesting a role for leptin in the maintenance of pregnancy. Synthesis of leptin by the human placenta is established but whether the murine placenta synthesizes l...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.03.009
更新日期:2005-01-01 00:00:00
abstract::Placenta accreta is a pregnancy complication characterized by the presence of life-threatening uteroplacental neovascularization. The factors involving its development are unknown. Vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors (VEGFR) have important roles in vascular remo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.12.011
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways. METHODS:Rats were fed a normal o...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.03.004
更新日期:2019-03-01 00:00:00
abstract::Corticosteroid conversion by early (7 to 10 weeks) and late (36 to 42 weeks) human placenta, fetal membranes and decidua was studied. Tritiated cortisol, cortisone, corticosterone, 11-dehydrocorticosterone (DHC) and 11-deoxycorticosterone (DOC) were incubated in vitro with homogenates of these tissues and extracts chr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(81)80025-2
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVES:Histiotrophe is now recognized as being an important feature of early human pregnancy, providing nutrients and growth factors to the developing embryo. Our aim was to examine the glycan composition of histiotrophe from first trimester decidua and to compare it with secretions present in endometrial glands fr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.04.011
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:We have identified some critical aspects concerning umbilical cord tissue mesenchymal stem cells: the lack of standards for cell isolation, expansion and cryopreservation, the lack of unanimous opinions upon their multilineage differentiation potential and the existence of very few results related to the f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.08.011
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.05.009
更新日期:2020-08-01 00:00:00
abstract::The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.07.006
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.03.009
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.04.003
更新日期:2007-04-01 00:00:00
abstract::The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1053/plac.1999.0512
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorioni...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.04.004
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Perfluorinated alkyl acids (PFAAs) are widely used in industry and consumer products. Pregnant women are exposed to PFAAs and their presence in umbilical cord blood represents fetal exposure. Interestingly, PFAAs are substrates for organic anion transporters (OAT) of which OAT4 is expressed in human placen...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.07.119
更新日期:2015-10-01 00:00:00
abstract::The ontogeny of Ia antigen expression on cells within the decidua basalis of the placenta and on decidual cells differentiating in vitro was investigated in the mouse. The results indicate that Ia antigen expression is temporarily restricted and can be detected in short-term cultures of decidual tissue only during the...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80027-7
更新日期:1983-04-01 00:00:00
abstract::Human parvovirus B19 (B19) infection during pregnancy can result in horizontal transmission of the virus and congenital infection. The main targets for B19 replication are the erythroid precursor cell of the colony and burst forming units. The cellular receptor necessary for B19 infectivity is globoside. Other non-ery...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0843
更新日期:2002-08-01 00:00:00
abstract::Previous clinical studies have shown the efficacy of a two-stage surgical procedure - the induced membrane (IM) technique - for reconstruction of large bone defects or bone non-union. The first stage involves radical debridement and insertion of a cement spacer into the bone defect. The second stage, performed weeks t...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2017.06.340
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:The interaction between trophoblast cells and maternal uterine endothelium is important for placental vascular modelling. Nitric oxide (NO) is a potent vasorelaxant that regulates systemic blood pressure and is reduced in preeclampsia. NO may affect placental cell interaction. OBJECTIVES:This study was to...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.03.009
更新日期:2014-06-01 00:00:00
abstract::Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80054-5
更新日期:1984-03-01 00:00:00
abstract::Breast Cancer Resistance Protein (BCRP), a recently-discovered transporter belonging to ABC superfamily, is highly expressed within the labyrinth of the placenta, the primary site of exchange between the maternal and fetal circulation. It has been proposed to function as an efflux pump protecting the fetus from a wide...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2007.03.010
更新日期:2007-10-01 00:00:00
abstract::Placental vascular tone is critically influenced by nitric oxide (NO) derived from endothelial NO synthase (eNOS) activity. Placental vessels from pregnancies complicated with intrauterine growth restriction present altered NOS-dependent vasodilation. Arginase-2 competes with eNOS for l-arginine and counteracts the NO...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.09.015
更新日期:2013-01-01 00:00:00
abstract::Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(05)80638-1
更新日期:1996-01-01 00:00:00
abstract::Cytophotometric measurement of the DNA content of Feulgen-stained nuclei in touch preparations of bovine placentomes (n =5) revealed that 8C nuclei occurred in all, 16C nuclei in two, and 32C nuclei in one specimen. The determination of ploidy level by in situ hybridization with a Y-chromosome specific DNA probe showe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0402
更新日期:1999-07-01 00:00:00
abstract::The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1998.0366
更新日期:1999-03-01 00:00:00
abstract::Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.018
更新日期:2020-10-13 00:00:00
abstract::Amino acid transfer to the fetus is dependent on several different factors. While these factors can be understood in isolation, it is still not possible to predict the function of the system as a whole. In order to do this an integrated approach is required which incorporates the interactions between the different det...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2012.10.010
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study exam...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.10.009
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:We investigated the feasibility of dynamic glucose enhanced (DGE) MRI in accessing placental function in a mouse model of intrauterine inflammatory injury (IUI). DGE uses the glucose chemical exchange saturation transfer (glucoCEST) effect to reflect infused d-glucose. METHODS:IUI was induced in pregnant ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.07.012
更新日期:2018-09-01 00:00:00
abstract::Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2008.08.007
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.031
更新日期:2020-11-14 00:00:00
abstract::An interaction between heparin and circulating pregnancy-associated plasma protein A (PAPP-A) has been observed. This interaction could be reversed by the addition of the specific heparin antagonist protamine sulphate. In the presence of heparin, crossed immunoelectrophoretic analysis revealed an alteration in the ele...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80013-7
更新日期:1983-01-01 00:00:00