Abstract：
:Previous clinical studies have shown the efficacy of a two-stage surgical procedure - the induced membrane (IM) technique - for reconstruction of large bone defects or bone non-union. The first stage involves radical debridement and insertion of a cement spacer into the bone defect. The second stage, performed weeks to months later, consists of removing the spacer while leaving the foreign body membrane induced by the cement in place, and then filling the cavity with bone autograft. The IM has been shown to (1) act as a protective physical barrier by preventing bone autograft resorption and (2) act as a bioreactor by promoting healing through revascularisation and growth factor secretion, and by concentrating mesenchymal stem cells (MSC) with osteogenic properties. New solutions to reduce this surgical procedure to a single step are being explored, for example by using an IM-like bioactive and protective barrier inserted into the bone defect at the same time as bone graft.
journal_name
Placentajournal_title
Placentaauthors
Gindraux F,Rondot T,de Billy B,Zwetyenga N,Fricain JC,Pagnon A,Obert Ldoi
10.1016/j.placenta.2017.06.340subject
Has Abstractpub_date
2017-11-01 00:00:00pages
116-123eissn
0143-4004issn
1532-3102pii
S0143-4004(17)30636-7journal_volume
59pub_type
杂志文章,评审相关文献
PLACENTA文献大全abstract：:Placental size has been an interesting topic of research for many years. The main aim of this study was to investigate the feasibility of measuring the placental volume at the end of the first trimester using three-dimensional (3D) ultrasound and to correlate these volumes to known placental functional indices and to ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0684
更新日期：2001-07-01 00:00:00
abstract：:Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.11.005
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Human decidual stromal cells (DSCs) play a key role in maternal-fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smoo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.11.010
更新日期：2018-01-01 00:00:00
abstract：:The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.12.018
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:miRNAs are small non-coding RNAs important for the regulation of mRNA in many organs including placenta. Adipokines and specifically leptin are known to be dysregulated in preeclampsia, but little is known regarding their regulation by miRNAs during pregnancy. METHODS:We performed high-throughput sequenci...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.07.002
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Air pollution has significant negative health impacts, particularly on the cardiovascular system. The aims of this narrative review were to identify whether there is an association between air pollution and the incidence of pre-eclampsia, and the potential mechanisms by which any effects may be mediated. ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2020.12.009
更新日期：2020-12-18 00:00:00
abstract：:The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.07.006
更新日期：2016-09-01 00:00:00
abstract：:We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2000.0610
更新日期：2001-02-01 00:00:00
abstract：INTRODUCTION:During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2014.11.021
更新日期：2015-02-01 00:00:00
abstract：:The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2019.02.013
更新日期：2019-09-01 00:00:00
abstract：:Theories on the development of placental pathologies and insufficiencies are based on the assumption that the development of the placental villous trees, the invasion of extravillous trophoblast or the differentiation of the villous trophoblast is somehow dysregulated. One of the pioneers trying to answer these questi...
journal_title：Placenta
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.placenta.2006.01.007
更新日期：2006-04-01 00:00:00
abstract：:Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2020.10.022
更新日期：2020-10-20 00:00:00
abstract：:Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.10.015
更新日期：2011-01-01 00:00:00
abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.08.081
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.02.001
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：:Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.03.007
更新日期：2011-06-01 00:00:00
abstract：:Preeclampsia is a leading cause of maternal and fetal morbidity and mortality in high and low-income countries. The aetiology of preeclampsia is multifactorial and remains obscure. Some evidences suggest that altered placental fatty acid oxidation might play a role in the pathogenesis of preeclampsia. To reveal if pla...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.11.027
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Pre-gravid obesity is associated with increased morbidity and mortality for both mother and offspring. Recent studies have demonstrated a heightened inflammatory response both systemically and locally within the adipose and placental tissue in women with pre-gravid obesity, which may play a role in mediating...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.12.023
更新日期：2011-03-01 00:00:00
abstract：:Breast Cancer Resistance Protein (BCRP), a recently-discovered transporter belonging to ABC superfamily, is highly expressed within the labyrinth of the placenta, the primary site of exchange between the maternal and fetal circulation. It has been proposed to function as an efflux pump protecting the fetus from a wide...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2007.03.010
更新日期：2007-10-01 00:00:00
abstract：:Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...
journal_title：Placenta
pub_type：
doi：10.1016/j.placenta.2008.11.014
更新日期：2009-03-01 00:00:00
abstract：INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.04.004
更新日期：2019-06-01 00:00:00
abstract：:The recent demonstration of multiple high-affinity leucine-sensitive cationic transport systems prompted this investigation of their role in lysine uptake in basal cell membrane. Transport of lysine by basal membrane was saturable at both 22 and 37 degrees C and linear in time to 1 min and 30 sec, respectively. At 22 ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(97)90006-0
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.09.011
更新日期：2020-01-01 00:00:00
abstract：:The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80194-8
更新日期：1990-11-01 00:00:00
abstract：:The transport of large amounts of Ca2+ by the plasma membranes of human placental syncytiotrophoblast is essential to the mineralization of the growing fetal skeleton. We have investigated transport by the basal (fetal-facing) plasma membrane (BPM). Ca2+ was taken up by purified BPM vesicles in a time-dependent manner...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80451-5
更新日期：1994-02-01 00:00:00
abstract：:Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/S0143-4004(03)00216-9
更新日期：2004-01-01 00:00:00
abstract：:Human placental fragments concentrate 86Rb 10--20-fold during a two-hour incubation period. Inhibition of ouabain is dose-dependent, reaching 90 + per cent at a concentration of 5 x 10(-5) M. The clearance index of 86Rb across the perfused human placenta is 0.34 +/- 0.08, comparing to previously reported indices for N...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80038-1
更新日期：1983-10-01 00:00:00
abstract：:The expression of apolipoprotein D (apo D), a lipocalin involved in defense mechanisms against oxidative stress, in placental tissue samples of pregnancies with gestational diabetes mellitus (GDM) was compared to non-diabetic controls. We have investigated the relationship of apo D with 4-HNE, a major propagation prod...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.11.002
更新日期：2010-01-01 00:00:00
abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(91)90007-3
更新日期：1991-05-01 00:00:00
