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Corticotrophin-releasing factor and urocortin inhibit system A activity in term human placental villous explants.

Abstract：

:Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CRF and urocortin inhibit placental system A activity. Chronic (48h) exposure of term placental villous explants to these hormones (10(-7)M) significantly reduced system A activity (Na(+)-dependent (14)C-methylaminoisobutyric acid uptake), whereas 1h exposure had no effect. We propose elevated CRF and urocortin contribute to FGR through negative regulation of placental system A activity.

journal_name

Placenta

journal_title

Placenta

authors

Giovannelli A,Greenwood SL,Desforges M,Sibley CP,Petraglia F

doi

10.1016/j.placenta.2010.10.015

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

99-101

issue

1

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(10)00404-2

journal_volume

32

pub_type

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