Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?

abstract：:The aim of this study was to investigate localization and content of activin beta A-subunit and activin receptors in gestational tissues throughout pregnancy and in association with term labour. Placenta and fetal membranes were collected from women undergoing first and second trimester terminations and from women bef...

journal_title：Placenta

authors： Schneider-Kolsky ME,Manuelpillai U,Waldron K,Dole A,Wallace EM

更新日期：2002-04-01 00:00:00

abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

journal_title：Placenta

authors： Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

更新日期：2005-11-01 00:00:00

abstract：:The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...

journal_title：Placenta

authors： Bennett FI,Jackson AA

更新日期：1998-05-01 00:00:00

abstract：:In human placenta aminopeptidase A (APA), a principal enzyme that converts angiotensin II to angiotensin III, seems to be involved in angiotensin II metabolism during pregnancy. In this study, we investigated the possible effects of progesterone and estrogen on APA mRNA and protein levels in choriocarcinoma cells as a...

journal_title：Placenta

authors： Katsumata Y,Nomura S,Ino K,Iwanaga K,Kurosawa N,Ito T,Okada M,Tsujimoto M,Kikkawa F,Mizutani S

更新日期：2001-11-01 00:00:00

abstract：:The marginal zone of the human term placenta was studied by transmission electron microscopy and immunohistochemistry using antibodies against cytoskeletal filaments, extracellular matrix molecules and endothelial markers. The marginal sinus of the intervillous space is separated from the chorionic and basal plates by...

journal_title：Placenta

authors： Nanaev AK,Kosanke G,Kemp B,Frank HG,Huppertz B,Kaufmann P

更新日期：2000-01-01 00:00:00

abstract：:The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...

journal_title：Placenta

authors： Thornburg KL,Kolahi K,Pierce M,Valent A,Drake R,Louey S

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:The ratio of birthweight to placental weight (BW:PW) is often used as a measure of placental efficiency in humans and animals. However, ratios have properties that are known to lead to spurious results. An alternative approach is the use of residuals from regression, which reflect whether birthweight is hi...

journal_title：Placenta

authors： Christians JK,Grynspan D,Greenwood SL,Dilworth MR

更新日期：2018-08-01 00:00:00

abstract：:Mice were inoculated with Theiler's murine encephalomyelitis virus (TMEV) on gestational days 1-3 (pre-implantation) or days 4-5 (peri- or post-implantation) or with control cell lysate (days 1-5). Dams were subsequently sacrificed between days 11-14 of gestation, and placentae and fetuses were harvested. Few placenta...

journal_title：Placenta

authors： Abzug MJ,Tyson RW

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic c...

journal_title：Placenta

authors： Labarrere CA,Hardin JW,Haas DM,Kassab GS

更新日期：2015-06-01 00:00:00

abstract：:Glutamine is the most versatile amino acid and its plasma concentration is the highest of all amino acid. Many transporters are therefore involved in glutamine uptake or efflux. Glutamine is actively released from the placenta into fetal circulation. In this study, we examined the alteration of transporters that trans...

journal_title：Placenta

authors： Yoshioka C,Yasuda S,Kimura F,Kobayashi M,Itagaki S,Hirano T,Iseki K

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Preeclampsia is characterized by maternal endothelial dysfunction. While the mechanisms leading to preeclampsia are unclear, a factor(s) from the placenta is responsible for triggering the disease. One placental factor implicated in triggering preeclampsia is trophoblast debris which may transmit pathogeni...

journal_title：Placenta

authors： Shen F,Wei J,Snowise S,DeSousa J,Stone P,Viall C,Chen Q,Chamley L

更新日期：2014-10-01 00:00:00

abstract：:Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...

journal_title：Placenta

authors： Kikkawa F,Shibata K,Suzuki T,Kajiyama H,Ino K,Nomura S,Mizutani S

更新日期：2004-02-01 00:00:00

abstract：:During placental development, human cytotrophoblast cells can differentiate to either villous syncytiotrophoblast cells or invasive extravillous trophoblast cells. We hypothesize that oxygen tension plays a critical role in determining the pathway of cytotrophoblast differentiation. A highly purified preparation of cy...

journal_title：Placenta

authors： Robins JC,Heizer A,Hardiman A,Hubert M,Handwerger S

更新日期：2007-11-01 00:00:00

abstract：:The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...

journal_title：Placenta

authors： Matsubara S,Yamada T,Minakami H,Watanabe T,Takizawa T,Sato I

更新日期：1999-03-01 00:00:00

abstract：INTRODUCTION:Research suggests that autism spectrum disorder (ASD) has its origins in utero. This study examines the association between evidence of placental histopathology and ASD. METHODS:Administrative claims data and medical records data were used to identify ASD cases (N = 55) and matched controls (N = 199) born...

journal_title：Placenta

authors： Straughen JK,Misra DP,Divine G,Shah R,Perez G,VanHorn S,Onbreyt V,Dygulska B,Schmitt R,Lederman S,Narula P,Salafia CM

更新日期：2017-09-01 00:00:00

abstract：:Homogenates of first (10.1 +/- 1.0 weeks) and third trimester placental villi were analysed for free amino acid concentrations. As has been previously reported, several amino acids showed increased concentrations during early pregnancy when compared to term. In addition, marked differences were seen in the levels of e...

journal_title：Placenta

authors： Sooranna SR,Burston D,Ramsay B,Steer PJ

更新日期：1994-10-01 00:00:00

abstract：:We have previously shown that thioredoxin and thioredoxin reductase were immunohistochemically localized in cytotrophoblasts, decidua and stromal cells in the stem villi of human placenta and that the addition of exogenous thioredoxin and thioredoxin reductase to mitochondrial fractions from human placenta displayed a...

journal_title：Placenta

authors： Ejima K,Koji T,Nanri H,Kashimura M,Ikeda M

更新日期：1999-09-01 00:00:00

abstract：INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...

journal_title：Placenta

authors： Olgun NS,Arita Y,Hanna M,Murthy A,Tristan S,Peltier MR,Hanna N

更新日期：2014-06-01 00:00:00

abstract：:Eighty-one placentae from women with leprosy and 17 placentae from healthy controls were subjected to a detailed macroscopic, light microscopic, ultrastructural, immunopathological, microbiological and biochemical study. The placental morphology and immunohistology were normal, and there was no morphological evidence ...

journal_title：Placenta

authors： Duncan ME,Fox H,Harkness RA,Rees RJ

更新日期：1984-05-01 00:00:00

abstract：:The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of numerous placental functions, including ion and nutrient exchange and the synthesis of steroid and peptide hormones required for fetal growth and development. Inadequate formation and regeneration of this tissue contributes ...

journal_title：Placenta

authors： Pidoux G,Gerbaud P,Cocquebert M,Segond N,Badet J,Fournier T,Guibourdenche J,Evain-Brion D

更新日期：2012-02-01 00:00:00

abstract：:Bovine nuclear transfer pregnancies are characterized by a high incidence of placental abnormalities, notably, increased placentome size and deficiencies in trophoblast cell function and establishment of placental vasculature. Alterations in gene expression during placental growth and development may contribute to the...

journal_title：Placenta

authors： Ravelich SR,Shelling AN,Wells DN,Peterson AJ,Lee RS,Ramachandran A,Keelan JA

更新日期：2006-02-01 00:00:00

abstract：:We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells ...

journal_title：Placenta

authors： Kameda T,Koyama M,Matsuzaki N,Taniguchi T,Saji F,Tanizawa O

更新日期：1991-01-01 00:00:00

abstract：:Recent studies have indicated that oxidative stress is involved in the pathogenesis of pre-eclampsia. Oxidative stress damages systemic tissues, and placental damage may result in intrauterine growth retardation and fetal distress. Thus, this study attempted to elucidate the placental localization of thioredoxin and t...

journal_title：Placenta

authors： Ejima K,Nanri H,Toki N,Kashimura M,Ikeda M

更新日期：1999-01-01 00:00:00

abstract：:Nitrotyrosine residues (NT), an index of oxidative stress arising from peroxynitrite formation and action, are found in placental vasculature of pregnancies complicated by pre-eclampsia (PE) or pregestational insulin-dependent diabetes mellitus (IDDM). This study correlates conventional placental pathology with NT imm...

journal_title：Placenta

authors： Stanek J,Eis AL,Myatt L

更新日期：2001-04-01 00:00:00

abstract：INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

journal_title：Placenta

authors： Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

更新日期：2013-10-01 00:00:00

abstract：:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...

journal_title：Placenta

authors： Dilworth MR,Kusinski LC,Baker BC,Renshall LJ,Baker PN,Greenwood SL,Wareing M,Sibley CP

更新日期：2012-12-01 00:00:00

abstract：:Placentae from controls and two groups of diabetic women (one White classes A, B, C and the other classes D, F/R) were collected at 37-42 weeks of gestation. Tissue sections were analysed using stereological methods in order to quantify the growth and maturational status of villi. Birth and placental weights were reco...

journal_title：Placenta

authors： Mayhew TM,Sørensen FB,Klebe JG,Jackson MR

更新日期：1994-01-01 00:00:00

abstract：:A rapid method to determine quality for placental proteomic studies is required due to varying lengths of time between delivery and sampling in routine protocols. We developed a rapid 10 min LC-MS based scanning method to profile free peptides liberated from natural proteolytic degradation. The assay was applied to pl...

journal_title：Placenta

authors： Heywood WE,Pryce J,Virasami A,Preece RL,Dezateux C,Mills K,Sebire NJ

更新日期：2016-08-01 00:00:00

abstract：:Respiratory parameters were studied in mitochondria from human placenta. Respiratory control and ADP/O ratios were low in this preparation. The adenine nucleotide content of placental mitochondria was found to be only one quarter of that found for adult uterine muscle tissue mitochondria prepared in the same way. Load...

journal_title：Placenta

authors： Illsley NP,Coade SB,Harkness RA

更新日期：1985-05-01 00:00:00

abstract：:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...

journal_title：Placenta

authors： Cooper EJ,Wareing M,Greenwood SL,Baker PN

更新日期：2006-04-01 00:00:00