Abstract:
:Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammatory and apoptotic responses in preeclamptic pregnancies. Placentas were collected from normotensive and preeclamptic pregnancies with either male or female fetuses (MPE and FPE respectively) after c-section at term with no labor. Expression patterns of markers of inflammation measured by ELISA, as well as hypoxia, apoptosis and angiogenesis markers measured by Western blotting were determined in the placenta. Consistent with previous studies, an increase in inflammation, hypoxia, and apoptotic cell death was observed in PE compared to normotensive pregnancies. Levels of TNFα, IL-6 and IL-8, and HIF-1α were significantly greater, whereas the angiogenic marker VEGF was significantly reduced in MPE vs. FPE. Sexual dimorphism was also observed in the activation of cell death: the number of TUNEL-positive cells, and the expression pro-apoptotic markers PUMA and Bax being higher in MPE vs. FPE. We also found an increase in the levels of protein and DNA-binding activity of NFκB p65 in MPE vs. FPE. In summary, we show here that in preeclamptic pregnancies the placentas of males were associated with significantly higher expression of inflammatory, hypoxia and apoptotic molecules but reduced expression of a pro-angiogenic marker compared to placentas of female fetuses. We propose that the transcription factor NFκB p65 might, at least partially, be involved in sexual dimorphism during PE.
journal_name
Placentajournal_title
Placentaauthors
Muralimanoharan S,Maloyan A,Myatt Ldoi
10.1016/j.placenta.2013.09.015subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1183-9issue
12eissn
0143-4004issn
1532-3102pii
S0143-4004(13)00741-8journal_volume
34pub_type
杂志文章相关文献
PLACENTA文献大全abstract:INTRODUCTION:Chronic abruption oligohydramnios sequence (CAOS) is histologically characterized by diffuse chorioamniotic hemosiderosis (DCH). However, the criteria for the histological evaluation of the extent of CAOS-related hemosiderin deposition (HD) of the membranes and the difference in HD between the chorionic pl...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2021.01.013
更新日期:2021-01-20 00:00:00
abstract::Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...
journal_title:Placenta
pub_type:
doi:10.1016/j.placenta.2008.11.014
更新日期:2009-03-01 00:00:00
abstract::Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.08.081
更新日期:2016-11-01 00:00:00
abstract:CONTEXT:Very few studies have measured the weight of large numbers of placentas delivered before the 28th post-menstrual week. METHODS:We measured the weight of 930 singleton placentas delivered before the 28th post-menstrual week, and examined the distributions of weights in selected groups (week of gestation, reason...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2007.04.009
更新日期:2007-10-01 00:00:00
abstract::MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to the circulation and their level in the plasma is altered in certain pathological conditions such as cancer, and also during pregnancy. We...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.07.001
更新日期:2010-09-01 00:00:00
abstract::Corticosteroid conversion by early (7 to 10 weeks) and late (36 to 42 weeks) human placenta, fetal membranes and decidua was studied. Tritiated cortisol, cortisone, corticosterone, 11-dehydrocorticosterone (DHC) and 11-deoxycorticosterone (DOC) were incubated in vitro with homogenates of these tissues and extracts chr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(81)80025-2
更新日期:1981-10-01 00:00:00
abstract::In the present study, we characterized the expression of lymphocyte antigen 6, locus E (Ly6e) in mouse placental trophoblast. We identified Ly6e mRNA expression in trophoblast stem (TS) cells by a gene expression screen. In vivo, Ly6e was first detectable by mRNA in situ hybridization in the chorion beginning at E8.5 ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.05.011
更新日期:2013-09-01 00:00:00
abstract::This report compares the relative levels of messenger RNA species coding for plasma proteins in rat visceral yolk sac and fetal liver from 12.5 days to 21.5 days gestation. Transthyretin, retinol-binding protein, transferrin and alpha 1-fetoprotein mRNAs were detected in both tissues, although relative levels were muc...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80216-4
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The human placenta extrudes a variety of extracellular vesicles (EVs) into the maternal blood daily. These vesicles may be crucial to the adaptation of the maternal cardiovascular and immune systems to pregnancy. Quantifying the EVs that are released in early gestation is important to our understanding of ho...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.10.009
更新日期:2018-12-01 00:00:00
abstract::Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence d...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/0143-4004(91)90015-8
更新日期:1991-03-01 00:00:00
abstract::Placental development is a highly regulated process requiring signals from both fetal and maternal uterine compartments. Within this complex system, trophoblasts, placental cells of epithelial lineage, form the maternal-fetal interface controlling nutrient, gas and waste exchange. The commitment of progenitor villous ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2014.12.016
更新日期:2015-04-01 00:00:00
abstract::Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/S0143-4004(03)00216-9
更新日期:2004-01-01 00:00:00
abstract::Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or mate...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.07.006
更新日期:2014-09-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2017.09.011
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Scant data on placental lymphatic vessels have pointed to the absence of lymphatic circulation. A recent study on mesenchymal dysplasia (MD), however, has identified pathologic lymphangiogenesis using the D2-40 lymphatic marker. These conflicting data have prompted us to investigate whether lymphatic vessels...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.01.013
更新日期:2011-04-01 00:00:00
abstract::The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2019.06.381
更新日期:2019-09-01 00:00:00
abstract::Accumulation of advanced oxidation protein products (AOPPs) is prevalent in obesity, advanced maternal age, diabetes mellitus, and polycystic ovary syndrome. Alterations in the regulation and signaling of angiogenic pathways have been recognized as a link between these conditions and pre-eclampsia. To investigate the ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.308
更新日期:2013-10-01 00:00:00
abstract::Respiratory parameters were studied in mitochondria from human placenta. Respiratory control and ADP/O ratios were low in this preparation. The adenine nucleotide content of placental mitochondria was found to be only one quarter of that found for adult uterine muscle tissue mitochondria prepared in the same way. Load...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(85)80049-7
更新日期:1985-05-01 00:00:00
abstract::Several xenobiotic-metabolizing mono-oxygenase activities, in conjunction with the immunohistochemical localization of the respective cytochrome P-450 forms, were investigated in placentae from smoking and non-smoking women. The antibodies used in the immunohistochemical analyses were monoclonal antibodies (MAbs) 1-7-...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90034-3
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.10.009
更新日期:2020-01-01 00:00:00
abstract::The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preecl...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2016.10.004
更新日期:2016-12-01 00:00:00
abstract::The placenta provides all energy and nutrient requirements for healthy fetal development. The placenta in rats is capable of storing glycogen, although the placenta cells must therefore mobilize stored glycogen to its own glucose supply. Moreover, maternal glucose and/or placental lactate furnished the fetal growth. A...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2003.11.005
更新日期:2004-05-01 00:00:00
abstract::Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.05.002
更新日期:2006-04-01 00:00:00
abstract::As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are lik...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2018.01.002
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To gain insight into the process of labor and the effects of labor on placental gene expression, we performed a microarray analysis to identify the differentially expressed transcripts that may participate in labor onset and progression. METHODS:We compared expression profiles in placentas from 16 women who...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.05.006
更新日期:2010-08-01 00:00:00
abstract:INTRODUCTION:Placental transport is the main factor affecting the health and development of the fetus. Due to the placenta's geometrical and mathematical complexity, the structure-function relations of placental terminal villi have not been successfully modeled. Hence, a novel modeling approach is proposed. METHODS:Co...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.05.001
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.12.006
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To study the association between velamentous cord insertion (VCI) and different outcomes in monochorionic twins with and without twin-twin transfusion syndrome (TTTS). METHODS:We recorded the cord insertion type in all consecutive monochorionic placentas examined in two tertiary medical centers. The associat...
journal_title:Placenta
pub_type: 杂志文章,多中心研究
doi:10.1016/j.placenta.2013.08.009
更新日期:2013-11-01 00:00:00
abstract::The trophoblastic and endodermal tissues of the guinea pig were cytophotometrically examined at two stages of development, either shortly after the primary trophoblastic giant cell layer had degenerated (Sansom and Hill, 1931) and the visceral yolk sac was starting to form (Kaufman and Davidoff, 1977) (c. 10.5 days p....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(81)80029-x
更新日期:1981-10-01 00:00:00
abstract::The uptake of [3H]choline and its conversion to [3H]acetylcholine were investigated in term human placental tissue in vitro. Although the net uptake of [3H]choline increased throughout a 45 min incubation period, intracellular [3H]choline levels reach a plateau after 2 min. There was a constant increase in [3H]acetylc...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80036-3
更新日期:1984-05-01 00:00:00