IFPA Meeting 2013 Workshop Report III: maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

abstract：:Glycogen storage disease type IV (GSD IV) is a rare autosomal recessive disorder caused by glycogen branching enzyme (GBE) deficiency and resulting in the storage of abnormal glycogen (polyglucosan). Prenatal diagnosis is based on biochemical assay of GBE activity or on mutation analysis, but polyglucosan can also be ...

journal_title：Placenta

authors： Konstantinidou AE,Anninos H,Dertinger S,Nonni A,Petersen M,Karadimas C,Havaki S,Marinos E,Akman HO,DiMauro S,Patsouris E

更新日期：2008-04-01 00:00:00

abstract：:Oestrogen and progesterone receptors have been implicated in human placental steroidogenesis, but studies developed to measure their concentration in this tissue at term yielded discrepant results. Potential inaccuracy of the binding assays, the technique used in previous studies, might influence the discrepancy. In t...

journal_title：Placenta

authors： Rivera J,Cano A

更新日期：1989-11-01 00:00:00

abstract：:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...

journal_title：Placenta

authors： Cooper EJ,Wareing M,Greenwood SL,Baker PN

更新日期：2006-04-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...

journal_title：Placenta

authors： Lafuste P,Robert B,Mondon F,Danan JL,Rossi B,Duc-Goiran P,Mignot TM,Nunez EA,Benassayag C,Ferré F

更新日期：2002-09-01 00:00:00

abstract：:11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate wo...

journal_title：Placenta

authors： Novembri R,Voltolini C,Torricelli M,Severi FM,Marcolongo P,Benedetti A,Challis JR,Petraglia F

更新日期：2013-11-01 00:00:00

abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

journal_title：Placenta

authors： Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:The antiphospholipid syndrome (APS) is characterized by the presence of circulating antiphospholipid antibodies (aPLs), is a leading cause for thromboembolic events, repeated miscarriage, fetal loss and is a major risk factor for fetal growth restriction (FGR) and preeclampsia. In human, anti-β2 glycoprotein...

journal_title：Placenta

authors： Kawaguchi R,Nunomura S,Umehara N,Nikaido T,Huppertz B,Tanaka T,Ra C

更新日期：2012-07-01 00:00:00

abstract：:Pregnancy induces a number of alterations to maternal physiology to accommodate the increased demands made by the developing fetus and placenta. These alterations appear at least in part to be driven by products derived from the feto-placental unit, including microchimeric cells, as well as placental exosomes and micr...

journal_title：Placenta

authors： Clifton VL,Stark MJ,Osei-Kumah A,Hodyl NA

更新日期：2012-02-01 00:00:00

abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...

journal_title：Placenta

authors： Braun T,Husar A,Challis JR,Dudenhausen JW,Henrich W,Plagemann A,Sloboda DM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Increasing evidence suggests an association between periodontal disease and low birthweight (LBW); however the underlying molecular mechanisms are yet to be fully elucidated. In this study, we performed a microarray analysis to observe the human placental trophoblast-like BeWo cells response to lipopolysaccha...

journal_title：Placenta

authors： Li Y,Shibata Y,Zhang L,Kuboyama N,Abiko Y

更新日期：2011-01-01 00:00:00

abstract：:In human placenta aminopeptidase A (APA), a principal enzyme that converts angiotensin II to angiotensin III, seems to be involved in angiotensin II metabolism during pregnancy. In this study, we investigated the possible effects of progesterone and estrogen on APA mRNA and protein levels in choriocarcinoma cells as a...

journal_title：Placenta

authors： Katsumata Y,Nomura S,Ino K,Iwanaga K,Kurosawa N,Ito T,Okada M,Tsujimoto M,Kikkawa F,Mizutani S

更新日期：2001-11-01 00:00:00

abstract：:During the first trimester in normal human pregnancy, endovascular trophoblast migrate along the decidual spiral arteries and invade their walls to produce physiological change. There is controversy as to whether invading trophoblast plug the arteries and prevent blood flow into the intervillous space. Using light mic...

journal_title：Placenta

authors： Meekins JW,Luckas MJ,Pijnenborg R,McFadyen IR

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Pre-gravid obesity is associated with increased morbidity and mortality for both mother and offspring. Recent studies have demonstrated a heightened inflammatory response both systemically and locally within the adipose and placental tissue in women with pre-gravid obesity, which may play a role in mediating...

journal_title：Placenta

authors： Roberts KA,Riley SC,Reynolds RM,Barr S,Evans M,Statham A,Hor K,Jabbour HN,Norman JE,Denison FC

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Placental transport is the main factor affecting the health and development of the fetus. Due to the placenta's geometrical and mathematical complexity, the structure-function relations of placental terminal villi have not been successfully modeled. Hence, a novel modeling approach is proposed. METHODS:Co...

journal_title：Placenta

authors： Plitman Mayo R,Charnock-Jones DS,Burton GJ,Oyen ML

更新日期：2016-07-01 00:00:00

abstract：:The localization of 5-hydroxytryptamine (5-HT) and its receptors in human placenta was studied under light and electron microscopy using immunohistochemistry and in situ hybridization. The syncytiotrophoblast, cytotrophoblast, stromal cells and decidual cells in human placentae all appeared to be 5-HT immunoreactive. ...

journal_title：Placenta

authors： Huang WQ,Zhang CL,Di XY,Zhang RQ

更新日期：1998-11-01 00:00:00

abstract：:The permeability of the rat placenta at 21 days' gestation (term is 23 days) has been measured with fetuses intact in situ and by perfusion of the fetal circulation. Intact measurements were made by removal of fetuses at known time intervals after injection of radioisotopes to the anaesthetized mother and measurement ...

journal_title：Placenta

authors： Robinson NR,Atkinson DE,Jones CJ,Sibley CP

更新日期：1988-07-01 00:00:00

abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

journal_title：Placenta

authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

更新日期：2008-10-01 00:00:00

abstract：:Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...

journal_title：Placenta

authors： Giovannelli A,Greenwood SL,Desforges M,Sibley CP,Petraglia F

更新日期：2011-01-01 00:00:00

abstract：:The human placenta possesses a large capacity for inactivation of prostanoids. This is due to the presence of large quantities of the NAD(+)-linked 15-hydroxy-prostaglandin dehydrogenase (PGDH type I; EC 1.1.1.141). In order to investigate whether a specific localization of PGDH is at the origin of the increasing plac...

journal_title：Placenta

authors： Erwich JJ,Keirse MJ

更新日期：1992-05-01 00:00:00

abstract：:There is accumulating evidence that deficient trophoblast invasion of the placental bed spiral arteries is crucial to the pathogenesis of pre-eclampsia and intrauterine growth restriction. However, the factors which regulate the process of trophoblast invasion remain unclear. We have investigated whether extravillous ...

journal_title：Placenta

authors： Lash GE,Cartwright JE,Whitley GS,Trew AJ,Baker PN

更新日期：1999-11-01 00:00:00

abstract：INTRODUCTION:The velocities of the lateral shear waves (Vs; m s⁻¹) generated by an acoustic radiation force impulse (ARFI) correlate with Young's modulus. Therefore, ARFI can be used as a new method to evaluate tissue elasticity. The aim of this study was to investigate the safety of ARFI imaging and the differences in...

journal_title：Placenta

authors： Sugitani M,Fujita Y,Yumoto Y,Fukushima K,Takeuchi T,Shimokawa M,Kato K

更新日期：2013-11-01 00:00:00

abstract：:Respiratory parameters were studied in mitochondria from human placenta. Respiratory control and ADP/O ratios were low in this preparation. The adenine nucleotide content of placental mitochondria was found to be only one quarter of that found for adult uterine muscle tissue mitochondria prepared in the same way. Load...

journal_title：Placenta

authors： Illsley NP,Coade SB,Harkness RA

更新日期：1985-05-01 00:00:00

abstract：:Prior studies have shown that levels of corticotrophin-releasing hormone (CRH) in the umbilical cord blood of infants born after pregnancies complicated by pre-eclampsia are significantly higher than fetal plasma CRH concentrations in uncomplicated pregnancies. In the present study we have measured CRH by radioimmunoa...

journal_title：Placenta

authors： Goland RS,Conwell IM,Jozak S

更新日期：1995-06-01 00:00:00

abstract：:The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast ...

journal_title：Placenta

authors： Bishop PW,Malam JE,Morris JA,Fox H

更新日期：1990-11-01 00:00:00

abstract：:A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from sever...

journal_title：Placenta

authors： Wasmoen TL,Benirschke K,Gleich GJ

更新日期：1987-05-01 00:00:00

abstract：INTRODUCTION:Knockout mouse model has shown a relationship between Slit2/Robo1 signalling and altered fertility. Altered expression by endometrial epithelium and trophoblast and is associated with the pathogenesis of pregnancy complications but few studies have investigated the expression of decidual Slit2 in miscarria...

journal_title：Placenta

authors： Chen J,Liu J,Gao S,Qiu Y,Wang Y,Zhang Y,Gao L,Qi G,Wu Y,Lash GE,Li P

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...

journal_title：Placenta

authors： Nakada E,Walley KR,Nakada T,Hu Y,von Dadelszen P,Boyd JH

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the...

journal_title：Placenta

authors： Beltrame JS,Sordelli MS,Cella M,Perez Martinez S,Franchi AM,Ribeiro ML

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Feeding pregnant broodmares with cereal concentrates has been shown to increase maternal insulin resistance and affect foal metabolism in the short and long-term. These effects are likely to be mediated by the placenta. Here, we investigated feto-placental biometry and placental structure and function at t...

journal_title：Placenta

authors： Robles M,Peugnet P,Dubois C,Piumi F,Jouneau L,Bouchez O,Aubrière MC,Dahirel M,Aioun J,Wimel L,Couturier-Tarrade A,Chavatte-Palmer P

更新日期：2018-04-01 00:00:00

abstract：:We have shown that oestrogen has a central integrative role in regulating key components of the progesterone biosynthetic and corticosteroid metabolic pathways within syncytiotrophoblasts that govern placental function and maturation of the fetal pituitary-adrenocortical axis. Studies utilizing classic binding procedu...

journal_title：Placenta

authors： Billiar RB,Pepe GJ,Albrecht ED

更新日期：1997-05-01 00:00:00