Abstract:
:Parathyroid hormone-related protein (PTHrP), the major factor responsible for hypercalcaemia of malignancy, is widely expressed in normal adult and fetal tissues. In this study, the distribution of PTHrP was examined in human term placenta and membranes by immunohistochemistry using antisera to PTHrP 1-34 and 37-67. PTHrP was detected in cuboidal epithelial cells of amnion and in cytotrophoblastic cells of chorionic laeve and adherent maternal decidua. In placenta, PTHrP 1-34 was detected in the syncytiotrophoblast, while PTHrP 37-67 activity was mainly present in the brush border of the syncytiotrophoblast. This study also identified PTHrP 37-67 associated with fetal vessels of placental villi. These findings may reflect the cellular distribution of intact PTHrP or sub-fragments derived by post-translational processing. Postulated actions of PTHrP in the uteroplacental unit include transport of calcium across the placenta, stretch of membranes, inhibition of uterine contractility, growth and differentiation, and vasoregulation.
journal_name
Placentajournal_title
Placentaauthors
Emly JF,Gregory J,Bowden SJ,Ahmed A,Whittle MJ,Rushton DI,Ratcliffe WAdoi
10.1016/s0143-4004(05)80411-4subject
Has Abstractpub_date
1994-09-01 00:00:00pages
653-60issue
6eissn
0143-4004issn
1532-3102pii
S0143-4004(05)80411-4journal_volume
15pub_type
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