Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.

abstract：INTRODUCTION:Decidual leukocytes are critical to the development of the fetomaternal interface, regulating tolerance to the semi-allogeneic fetus and vascular transformation of the uterine spiral arteries. Despite the continuation of these processes beyond the first trimester of pregnancy, the second trimester has larg...

journal_title：Placenta

authors： Kwan M,Hazan A,Zhang J,Jones RL,Harris LK,Whittle W,Keating S,Dunk CE,Lye SJ

更新日期：2014-12-01 00:00:00

abstract：:The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...

journal_title：Placenta

authors： Conrad KP,Davis AK

更新日期：1995-12-01 00:00:00

abstract：CONTEXT:Very few studies have measured the weight of large numbers of placentas delivered before the 28th post-menstrual week. METHODS:We measured the weight of 930 singleton placentas delivered before the 28th post-menstrual week, and examined the distributions of weights in selected groups (week of gestation, reason...

journal_title：Placenta

authors： Hecht JL,Kliman HJ,Allred EN,Pflueger SM,Chang CH,Doss BJ,Roberts D,Livasy CA,Bhan I,Zambrano E,Ross DW,Senagore P,Husain AN,Leviton A

更新日期：2007-10-01 00:00:00

abstract：:The present study was designed to localize some important enzymes, such as adenosine diphospate-degrading enzyme (ADP-degrading enzyme) (plasma membrane enzyme), cytochrome c oxidase (mitochondrial enzyme) and glucose-6-phosphatase (endoplasmic reticulum enzyme), in placentae from patients with idiopathic fetal growth...

journal_title：Placenta

authors： Matsubara S,Sato I

更新日期：2000-03-01 00:00:00

abstract：:Homogenates of first (10.1 +/- 1.0 weeks) and third trimester placental villi were analysed for free amino acid concentrations. As has been previously reported, several amino acids showed increased concentrations during early pregnancy when compared to term. In addition, marked differences were seen in the levels of e...

journal_title：Placenta

authors： Sooranna SR,Burston D,Ramsay B,Steer PJ

更新日期：1994-10-01 00:00:00

abstract：:The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...

journal_title：Placenta

authors： Rhon-Calderon EA,Vrooman LA,Riesche L,Bartolomei MS

更新日期：2019-09-01 00:00:00

abstract：:The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...

journal_title：Placenta

authors： Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani K

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...

journal_title：Placenta

authors： Salafia CM,Yampolsky M,Shlakhter A,Mandel DH,Schwartz N

更新日期：2012-03-01 00:00:00

abstract：:To characterize the placental activity for the transport of amino acids, the uptake of L-alanine was investigated by rapid membrane filtration using brush border membrane vesicles separated from the human placenta of early pregnant (12-13 gestational weeks) and late pregnant (37-38 gestational weeks) women. The uptake...

journal_title：Placenta

authors： Iioka H,Hisanaga H,Moriyama IS,Akada S,Shimamoto T,Yamada Y,Ichijo M

更新日期：1992-03-01 00:00:00

abstract：:Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...

journal_title：Placenta

authors： Ying X,Zhu Y,Jin X,Chang X

更新日期：2020-10-20 00:00:00

abstract：:Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease. It is based on the concept that application of gene therapy vectors to the fetus in utero may prevent the development of early disease related tissue damage, may allow targeting of otherwise inaccessible organs, tissues and still e...

journal_title：Placenta

authors： Coutelle C,Themis M,Waddington S,Gregory L,Nivsarkar M,Buckley S,Cook T,Rodeck C,Peebles D,David A

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta. METHODS:Placental slides of 224 singleton pregnancies with gross cord abnormality (true knots, long cord...

journal_title：Placenta

authors： Tantbirojn P,Saleemuddin A,Sirois K,Crum CP,Boyd TK,Tworoger S,Parast MM

更新日期：2009-12-01 00:00:00

abstract：:In human placenta aminopeptidase A (APA), a principal enzyme that converts angiotensin II to angiotensin III, seems to be involved in angiotensin II metabolism during pregnancy. In this study, we investigated the possible effects of progesterone and estrogen on APA mRNA and protein levels in choriocarcinoma cells as a...

journal_title：Placenta

authors： Katsumata Y,Nomura S,Ino K,Iwanaga K,Kurosawa N,Ito T,Okada M,Tsujimoto M,Kikkawa F,Mizutani S

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...

journal_title：Placenta

authors： Allsopp R,Shimoda J,Easa D,Ward K

更新日期：2007-04-01 00:00:00

abstract：:An interaction between heparin and circulating pregnancy-associated plasma protein A (PAPP-A) has been observed. This interaction could be reversed by the addition of the specific heparin antagonist protamine sulphate. In the presence of heparin, crossed immunoelectrophoretic analysis revealed an alteration in the ele...

journal_title：Placenta

authors： Westergaard JG,Hau J,Teisner B,Grudzinskas JG

更新日期：1983-01-01 00:00:00

abstract：:The aim of this study was to investigate localization and content of activin beta A-subunit and activin receptors in gestational tissues throughout pregnancy and in association with term labour. Placenta and fetal membranes were collected from women undergoing first and second trimester terminations and from women bef...

journal_title：Placenta

authors： Schneider-Kolsky ME,Manuelpillai U,Waldron K,Dole A,Wallace EM

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:The interaction between trophoblast cells and maternal uterine endothelium is important for placental vascular modelling. Nitric oxide (NO) is a potent vasorelaxant that regulates systemic blood pressure and is reduced in preeclampsia. NO may affect placental cell interaction. OBJECTIVES:This study was to...

journal_title：Placenta

authors： Xu B,Charlton F,Makris A,Hennessy A

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study exam...

journal_title：Placenta

authors： Dubruc E,Lebreton F,Giannoli C,Rabilloud M,Huissoud C,Devouassoux-Shisheboran M,Allias F

更新日期：2016-12-01 00:00:00

abstract：:Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...

journal_title：Placenta

authors： Pongcharoen S,Somran J,Sritippayawan S,Niumsup P,Chanchan P,Butkhamchot P,Tatiwat P,Kunngurn S,Searle RF

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...

journal_title：Placenta

authors： Prat C,Bouvier D,Comptour A,Marceau G,Belville C,Clairefond G,Blanc P,Gallot D,Blanchon L,Sapin V

更新日期：2015-08-01 00:00:00

abstract：:The binding of oestradiol in human placental tissue obtained from spontaneous and caesarean deliveries was investigated. Villous tissue was homogenized and the 800 g 'cytosol' supernatant treated with ammonium sulphate. The precipitate was redissolved and the preparation then equilibrated with [3H]oestradiol. After se...

journal_title：Placenta

authors： Laminski NA,Hammond KD

更新日期：1985-09-01 00:00:00

abstract：:Glycogen storage disease type IV (GSD IV) is a rare autosomal recessive disorder caused by glycogen branching enzyme (GBE) deficiency and resulting in the storage of abnormal glycogen (polyglucosan). Prenatal diagnosis is based on biochemical assay of GBE activity or on mutation analysis, but polyglucosan can also be ...

journal_title：Placenta

authors： Konstantinidou AE,Anninos H,Dertinger S,Nonni A,Petersen M,Karadimas C,Havaki S,Marinos E,Akman HO,DiMauro S,Patsouris E

更新日期：2008-04-01 00:00:00

abstract：:Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...

journal_title：Placenta

authors： Zhao S,Gu Y,Dong Q,Fan R,Wang Y

更新日期：2008-12-01 00:00:00

abstract：:To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after stimulation with various modulatory agents of cytokine ex...

journal_title：Placenta

authors： Fujisawa K,Nasu K,Arima K,Sugano T,Narahara H,Miyakawa I

更新日期：2000-05-01 00:00:00

abstract：:Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the pres...

journal_title：Placenta

authors： von Versen-Höynck F,Rajakumar A,Bainbridge SA,Gallaher MJ,Roberts JM,Powers RW

更新日期：2009-05-01 00:00:00

abstract：:Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits troph...

journal_title：Placenta

authors： Pan Q,Niu H,Cheng L,Li X,Zhang Q,Ning Y

更新日期：2017-05-01 00:00:00

abstract：:In view of the pathological placental features of pre-eclampsia and intrauterine growth restriction (IUGR), and the angiogenic effects of vascular endothelial growth factor (VEGF), the aim of this study was to determine the expression of VEGF in placentae from normal pregnancies and to compare the results with placent...

journal_title：Placenta

authors： Lyall F,Young A,Boswell F,Kingdom JC,Greer IA

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...

journal_title：Placenta

authors： Moon KC,Park JS,Norwitz ER,Kim DI,Oh KJ,Park CW,Jun JK,Syn HC

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that pregnancies complicated by placentas with an isolated single umbilical artery (iSUA) are at increased risk for small-for-gestational-age (SGA) births. The etiology of SGA in this population, however, remains unknown. OBJECTIVE:The primary objective of this study was to evalu...

journal_title：Placenta

authors： Battarbee AN,Palatnik A,Ernst LM,Grobman WA

更新日期：2017-11-01 00:00:00

abstract：:Uterine blood flow (UtBF) is a major regulator of transplacental fetal nutrient supply. The aim was to serially measure uterine blood flow from mid to late pregnancy in a paradigm of relatively late onset placental and fetal growth restriction. Singleton bearing adolescent dams was fed high (H) or control (C) nutrient...

journal_title：Placenta

authors： Wallace JM,Milne JS,Matsuzaki M,Aitken RP

更新日期：2008-08-01 00:00:00