Abstract:
:The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that fetal MSC may be CD34 positive in vivo. We flow sorted term placental digests based on CD34+ expression and exploited differential culture media to isolate separately pure fetal and maternal MSC populations. This method has considerable translational implications, in particular to clinical trials underway with "placental" MSC of uncertain or decidual origin.
journal_name
Placentajournal_title
Placentaauthors
Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani Kdoi
10.1016/j.placenta.2014.09.001subject
Has Abstractpub_date
2014-11-01 00:00:00pages
969-71issue
11eissn
0143-4004issn
1532-3102pii
S0143-4004(14)00777-2journal_volume
35pub_type
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