当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases.

Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases.

Abstract：

BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study examined 21 placentas from FNAIT-affected pregnancies and 42 age-matched control cases, all collected from pathology departments in the Rhône-Alpes region. Clinical and laboratory findings were collected for each FNAIT case. Two pathologists reviewed the placental slides of each FNAIT and control case. Histological features, with special emphasis on chronic inflammatory lesions, were evaluated. Differences between the two groups were calculated with odds ratios (ORs) and assessed with Wald's chi-square. RESULTS:FNAIT was associated with a significantly higher frequency of chronic chorioamnionitis (CC) (OR 14, 95%CI 1.7-113.8), basal chronic villitis (BCV) (OR 17, 95%CI 2-145.6) and chronic intervillositis (CIV). Chronic villitis (CV) (OR 3.7, 95%CI 0.9-15.2) and chronic deciduitis (CD) (OR 4.7, 95%CI 0.79-28.2) were also more frequent in the FNAIT than the control group, but these differences were not statistically significant. CONCLUSIONS:FNAIT is significantly associated with CC, BCV, and CIV. This chronic inflammatory reaction is preferentially localized on the maternofetal interface. Anti-HPA alloimmunization may trigger an immunological conflict similar to graft-versus-host disease.

journal_name

Placenta

journal_title

Placenta

authors

Dubruc E,Lebreton F,Giannoli C,Rabilloud M,Huissoud C,Devouassoux-Shisheboran M,Allias F

doi

10.1016/j.placenta.2016.10.009

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

104-109

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(16)30556-2

journal_volume

48

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Accelerated expression of Ca antigen by placental villous trophoblast in pre-eclampsia.

    abstract：:The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(05)80194-8

    authors： Bishop PW,Malam JE,Morris JA,Fox H

    更新日期：1990-11-01 00:00:00

  • On the factors which contribute to thinning of the villous membrane in human placentae at high altitude. I. Thinning and regional variation in thickness of trophoblast.

    abstract：:Sections of human term placentae delivered at low and high altitude to indigenous and non-indigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indic...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(88)90067-7

    authors： Jackson MR,Mayhew TM,Haas JD

    更新日期：1988-01-01 00:00:00

  • Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment.

    abstract：:Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The meta...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2018.05.011

    authors： Delhaes F,Giza SA,Koreman T,Eastabrook G,McKenzie CA,Bedell S,Regnault TRH,de Vrijer B

    更新日期：2018-09-01 00:00:00

  • Downregulation of HLA class I gene transcription in choriocarcinoma cells is controlled by the proximal promoter element and can be reversed by CIITA.

    abstract：:The expression pattern of MHC class I genes in trophoblast cells at the feto-maternal interface is thought to be the basis of the maintenance of pregnancy by protecting the fetus from maternal immune rejection. Transcription of classical HLA class I genes is low or undetectable in most trophoblast cells as well as in ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1998.0380

    authors： Lefebvre S,Moreau P,Dausset J,Carosella ED,Paul P

    更新日期：1999-05-01 00:00:00

  • Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.

    abstract：INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.01.004

    authors： Li C,Raikwar NS,Santillan MK,Santillan DA,Thomas CP

    更新日期：2015-04-01 00:00:00

  • Postdate pregnancy: changes of placental/membranes 11β-hydroxysteroid dehydrogenase mRNA and activity.

    abstract：:11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate wo...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.08.011

    authors： Novembri R,Voltolini C,Torricelli M,Severi FM,Marcolongo P,Benedetti A,Challis JR,Petraglia F

    更新日期：2013-11-01 00:00:00

  • Ia antigen-bearing decidual cells and macrophages in cultures of mouse decidual tissue.

    abstract：:The ontogeny of Ia antigen expression on cells within the decidua basalis of the placenta and on decidual cells differentiating in vitro was investigated in the mouse. The results indicate that Ia antigen expression is temporarily restricted and can be detected in short-term cultures of decidual tissue only during the...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(83)80027-7

    authors： Searle RF,Bell SC,Billington WD

    更新日期：1983-04-01 00:00:00

  • Umbilical cord as an analytical matrix - A technical note.

    abstract：:The umbilical cord (UC) connects the fetal blood supply to the placenta, so is exposed to all systemic endo- and xenobiotics. We have extensive experience using UC as an analytical matrix for detecting and/or quantitating drugs, chemicals and endogenous compounds. This technical note describes advantages (large amount...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.12.001

    authors： Price HR,Chehroudi C,Knight SJ,Smith AD,Lai D,Kim H,Wright TE,Coughtrie MW,Collier AC

    更新日期：2020-01-15 00:00:00

  • Morphomics: An integral part of systems biology of the human placenta.

    abstract：INTRODUCTION:The placenta is a transient organ the functioning of which has health consequences far beyond the embryo/fetus. Understanding the biology of any system (organ, organism, single cell, etc) requires a comprehensive and inclusive approach which embraces all the biomedical disciplines and 'omic' technologies a...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2015.01.001

    authors： Mayhew TM

    更新日期：2015-04-01 00:00:00

  • Multiple human papillomavirus types replicate in 3A trophoblasts.

    abstract：:Human papillomavirus (HPV) are more prevalent in spontaneous abortions than elect abortions and preferentially infect the trophoblasts. Related to this, HPV type 16 has been shown to productively replicate in 3A trophoblasts in tissue culture. Extending these earlier studies, the described study addresses the issue wh...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2007.08.005

    authors： You H,Liu Y,Agrawal N,Prasad CK,Edwards JL,Osborne AF,Korourian S,Lowery CL,Hermonat PL

    更新日期：2008-01-01 00:00:00

  • Alpha-fetoprotein gene expression in early and full-term human trophoblast.

    abstract：:Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0816

    authors： Lafuste P,Robert B,Mondon F,Danan JL,Rossi B,Duc-Goiran P,Mignot TM,Nunez EA,Benassayag C,Ferré F

    更新日期：2002-09-01 00:00:00

  • A function of the allantoic sac in the metabolism of uteroferrin and maternal iron by the fetal pig.

    abstract：:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phospha...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：

    authors： Buhi WC,Ducsay CA,Bartol FF,Bazer FW,Roberts RM

    更新日期：1983-01-01 00:00:00

  • Uptake of microparticles by rat visceral yolk sac.

    abstract：:The visceral yolk sac (VYS) is responsible for a major part of the amino acid nutrition of the early post-implantation rat embryo and possibly also at the fetal stage of gestation. The mechanism involves endocytic uptake of proteins by the tissue's epithelial cells followed by intralysosomal digestion to amino acids. ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(77)90009-1

    authors： Pratten MK,Lloyd JB

    更新日期：1997-09-01 00:00:00

  • Autophagy in placentas from acidotic newborns: an immunohistochemical study of LC3 expression.

    abstract：:Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining wit...

    journal_title：Placenta

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.placenta.2013.09.004

    authors： Avagliano L,Danti L,Doi P,Felis S,Guala M,Locatelli A,Maffeo I,Mecacci F,Plevani C,Simeone S,Bulfamante GP

    更新日期：2013-11-01 00:00:00

  • In vitro fertilization is associated with the onset and progression of preeclampsia.

    abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.09.011

    authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

    更新日期：2020-01-01 00:00:00

  • Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells.

    abstract：BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.07.001

    authors： Nakada E,Walley KR,Nakada T,Hu Y,von Dadelszen P,Boyd JH

    更新日期：2009-09-01 00:00:00

  • The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase.

    abstract：:The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2000.0582

    authors： Danzeisen R,Ponnambalam S,Lea RG,Page K,Gambling L,McArdle HJ

    更新日期：2000-11-01 00:00:00

  • Review: Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta.

    abstract：:The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of numerous placental functions, including ion and nutrient exchange and the synthesis of steroid and peptide hormones required for fetal growth and development. Inadequate formation and regeneration of this tissue contributes ...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2011.11.007

    authors： Pidoux G,Gerbaud P,Cocquebert M,Segond N,Badet J,Fournier T,Guibourdenche J,Evain-Brion D

    更新日期：2012-02-01 00:00:00

  • Expression of pregnancy-associated plasma protein-A (PAPP-A) during human villous trophoblast differentiation in vitro.

    abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0944

    authors： Guibourdenche J,Frendo JL,Pidoux G,Bertin G,Luton D,Muller F,Porquet D,Evain-Brion D

    更新日期：2003-05-01 00:00:00

  • Impact of placental growth factor deficiency on early mouse implant site angiogenesis.

    abstract：:Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or mate...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.07.006

    authors： Rätsep MT,Carmeliet P,Adams MA,Croy BA

    更新日期：2014-09-01 00:00:00

  • First-trimester placental thickness and the risk of preeclampsia or SGA.

    abstract：INTRODUCTION:Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestatio...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.06.016

    authors： Vachon-Marceau C,Demers S,Markey S,Okun N,Girard M,Kingdom J,Bujold E

    更新日期：2017-09-01 00:00:00

  • The human placenta is encircled by a ring of smooth muscle cells.

    abstract：:The marginal zone of the human term placenta was studied by transmission electron microscopy and immunohistochemistry using antibodies against cytoskeletal filaments, extracellular matrix molecules and endothelial markers. The marginal sinus of the intervillous space is separated from the chorionic and basal plates by...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1999.0455

    authors： Nanaev AK,Kosanke G,Kemp B,Frank HG,Huppertz B,Kaufmann P

    更新日期：2000-01-01 00:00:00

  • Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells.

    abstract：:Long-chain polyunsaturated fatty acids (LCPUFAs) such as docosahexaenoic acid (DHA) and arachidonic acid (AA) are essential for proper development of fetal brain and retina. These LCPUFAs are selectively enriched in the fetal circulation compared with the maternal circulation. In the current study we investigated the ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.10.007

    authors： Tobin KA,Johnsen GM,Staff AC,Duttaroy AK

    更新日期：2009-01-01 00:00:00

  • Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts.

    abstract：:Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0774

    authors： Udagawa K,Yasumitsu H,Esaki M,Sawada H,Nagashima Y,Aoki I,Jin M,Miyagi E,Nakazawa T,Hirahara F,Miyazaki K,Miyagi Y

    更新日期：2002-02-01 00:00:00

  • IFPA Senior Award Lecture: Reproductive immunology in perspective--reprogramming at the maternal-fetal interface.

    abstract：:Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Now, more than half a century later, it is well understood that with the initiation of pregnancy, immune cel...

    journal_title：Placenta

    pub_type：

    doi：10.1016/j.placenta.2012.12.005

    authors： Hunt JS,Petroff MG

    更新日期：2013-03-01 00:00:00

  • Demonstration of immunoreactive eosinophil granule major basic protein in the plasma and placentae of non-human primates.

    abstract：:A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from sever...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(87)90052-x

    authors： Wasmoen TL,Benirschke K,Gleich GJ

    更新日期：1987-05-01 00:00:00

  • Angiotensin II and its different receptor subtypes in placenta and fetal membranes.

    abstract：:The recent discovery of a local renin-angiotensin system in trophoblastic tissues has raised many questions regarding its role in the physiology of normal gestation and its implications in the pathophysiology of hypertension during pregnancy. In this article, the authors first review the most interesting aspects of th...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(96)80003-8

    authors： Kalenga MK,de Gasparo M,Thomas K,de Hertogh R

    更新日期：1996-03-01 00:00:00

  • Ultrasound and endocrinological markers of first trimester placentation and subsequent fetal size.

    abstract：INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.02.005

    authors： David AL,Jauniaux E

    更新日期：2016-04-01 00:00:00

  • Cyclic AMP as a second messenger for prorenin release from human decidual cells.

    abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(91)90007-3

    authors： Poisner AM,Thrailkill K,Poisner R,Handwerger S

    更新日期：1991-05-01 00:00:00

  • The effect of maternal hypoaminoacidaemia on placental uptake and transport of amino acids in pregnant sheep.

    abstract：:We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2000.0610

    authors： Thureen PJ,Padbury JF,Hay WW Jr

    更新日期：2001-02-01 00:00:00