Abstract：
:The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental function. Disturbances that occur during the establishment and maintenance of imprinting could compromise the placenta and fetus, and ultimately, offspring health. Assisted Reproductive Technologies (ART) have been widely used to overcome infertility, however experimental studies have shown that ART procedures affect placentation and the expression of imprinted genes. Here we briefly review the role of imprinted genes in placental development and the evidence from mouse and human studies suggesting ART disrupts imprinted gene regulation in the placenta.
journal_name
Placentajournal_title
Placentaauthors
Rhon-Calderon EA,Vrooman LA,Riesche L,Bartolomei MSdoi
10.1016/j.placenta.2019.02.013subject
Has Abstractpub_date
2019-09-01 00:00:00pages
37-43eissn
0143-4004issn
1532-3102pii
S0143-4004(19)30002-5journal_volume
84pub_type
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