Localization of thioredoxin reductase and thioredoxin in normal human placenta and their protective effect against oxidative stress.

abstract：BACKGROUND:The introduction of the Solomon technique for the treatment of twin-twin transfusion syndrome (TTTS) increased placental exposure to laser energy. This study aims to identify the impact of power and energy used in laser treatment on placental tissue and pregnancy outcome. METHODS:Pictures of all dye-injecte...

journal_title：Placenta

authors： Akkermans J,de Vries SM,Zhao D,Peeters SHP,Klumper FJ,Middeldorp JM,Oepkes D,Slaghekke F,Lopriore E

更新日期：2017-04-01 00:00:00

abstract：:Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential. It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause of infant mortality and morbidity. There is no treatment currently available for FGR. Its primary cause, when not attributable...

journal_title：Placenta

authors： Swanson AM,David AL

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the relationship between the retention of fetal membranes (RFM) and apoptosis of the cells in fetal membranes. The present study investigated mRNA and protein expressions of apoptosis-regulating factors: FAS, cellular FLICE-like inhibiting protein (cFLIP), BAX, BCL2, caspas...

journal_title：Placenta

authors： Kamemori Y,Wakamiya K,Nishimura R,Hosaka Y,Ohtani S,Okuda K

更新日期：2011-01-01 00:00:00

abstract：:Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...

journal_title：Placenta

authors： Hutson JR,Koren G,Matthews SG

更新日期：2010-05-01 00:00:00

abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

journal_title：Placenta

authors： Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

更新日期：2001-05-01 00:00:00

abstract：:The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...

journal_title：Placenta

authors： Schneider H

更新日期：2000-03-01 00:00:00

abstract：:Endotheliochorial placentas occur in orders from all four major clades of eutherian mammal. Species with this type of placenta include one of the smallest (pygmy shrew) and largest (African elephant) land mammals. The endotheliochorial placenta as a definitive form has an interhemal area consisting of maternal endothe...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2012-05-01 00:00:00

abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...

journal_title：Placenta

authors： Guibourdenche J,Frendo JL,Pidoux G,Bertin G,Luton D,Muller F,Porquet D,Evain-Brion D

更新日期：2003-05-01 00:00:00

abstract：:We tested the hypothesis that the expression of placental connective tissue growth factor (CTGF) is enhanced in pregnancies complicated by severe preeclampsia (PE) or fetal growth restriction (FGR). CTGF expression was analyzed using immunostaining, western blot and real-time quantitative PCR in placental samples obta...

journal_title：Placenta

authors： Oh SY,Song SE,Seo ES,Kim KH,Choi SJ,Suh YL,Sadovsky Y,Roh CR

更新日期：2009-11-01 00:00:00

abstract：:Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...

journal_title：Placenta

authors： Fonseca BM,Teixeira NA,Almada M,Taylor AH,Konje JC,Correia-da-Silva G

更新日期：2011-06-01 00:00:00

abstract：:Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2013 there were twelve themed workshops, three of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of placent...

journal_title：Placenta

authors： Abumaree MH,Brownbill P,Burton G,Castillo C,Chamley L,Croy BA,Drewlo S,Dunk C,Girard S,Hansson S,Jones S,Jurisicova A,Lewis R,Letarte M,Parast M,Pehrson C,Rappolee D,Schneider H,Tannetta D,Varmuza S,Wadsack C,Wa

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Notch signalling has been shown to control cytotrophoblast (CTB) proliferation, differentiation and motility suggesting that the conserved signalling pathway could be critical for human placental development. Since individual Notch receptors have not been elucidated, we herein investigated expression patte...

journal_title：Placenta

authors： Plessl K,Haider S,Fiala C,Pollheimer J,Knöfler M

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Placental abruption is a serious pregnancy complication that causes maternal and neonatal mortality and morbidity. Whether maternal and neonatal outcomes differ between patients who concurrently presented with preeclampsia and those who did not, have not been fully investigated. METHODS:A total number of ...

journal_title：Placenta

authors： Han M,Liu D,Zeb S,Li C,Tong M,Li X,Chen Q

更新日期：2019-09-15 00:00:00

abstract：:Pregnancy-associated plasma protein-A was assayed in the blood of 347 women during pregnancy, using a new primary standard of PAPP-A as reference. The protein was assayed by antibody-antigen crossed electrophoresis with the lower limit of confident assay being 9.5 micrograms PAPP-A/ml (13 pmol/ml). PAPP-A was first de...

journal_title：Placenta

authors： Sutcliffe RG,Kukulska-Langlands BM,Horne CH,Maclean AB,Jandial V,Sutherland HW,Gibb S,Bowman AW

更新日期：1982-01-01 00:00:00

abstract：INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...

journal_title：Placenta

authors： Prat C,Bouvier D,Comptour A,Marceau G,Belville C,Clairefond G,Blanc P,Gallot D,Blanchon L,Sapin V

更新日期：2015-08-01 00:00:00

abstract：:The human placenta possesses a large capacity for inactivation of prostanoids. This is due to the presence of large quantities of the NAD(+)-linked 15-hydroxy-prostaglandin dehydrogenase (PGDH type I; EC 1.1.1.141). In order to investigate whether a specific localization of PGDH is at the origin of the increasing plac...

journal_title：Placenta

authors： Erwich JJ,Keirse MJ

更新日期：1992-05-01 00:00:00

abstract：:The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast ...

journal_title：Placenta

authors： Bishop PW,Malam JE,Morris JA,Fox H

更新日期：1990-11-01 00:00:00

abstract：:The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...

journal_title：Placenta

authors： Racca AC,Ridano ME,Bandeira CL,Bevilacqua E,Avvad Portari E,Genti-Raimondi S,Graham CH,Panzetta-Dutari GM

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...

journal_title：Placenta

authors： Olgun NS,Arita Y,Hanna M,Murthy A,Tristan S,Peltier MR,Hanna N

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:In humans, it is known that blood flow is directed to the gravid uterus from two (right and left) pelvic uterine arteries. The extent of supply from the tubo-ovarian anastomosis (joining of the ovarian and uterine arteries) is unknown. The aim of this study was to delineate the arterial blood supply to the p...

journal_title：Placenta

authors： Balasuriya H,Bell P,Waugh R,Thompson J,Gillin A,Hennessy A,Makris A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Decidual leukocytes are critical to the development of the fetomaternal interface, regulating tolerance to the semi-allogeneic fetus and vascular transformation of the uterine spiral arteries. Despite the continuation of these processes beyond the first trimester of pregnancy, the second trimester has larg...

journal_title：Placenta

authors： Kwan M,Hazan A,Zhang J,Jones RL,Harris LK,Whittle W,Keating S,Dunk CE,Lye SJ

更新日期：2014-12-01 00:00:00

abstract：:The present study was designed to quantify the major cellular metabolites in human placentae and their changes due to the confounding effect of time and subsequent hypoxia during sample collection using magnetic resonance spectroscopy ((1)H-and (31)P-MRS). The absolute placental concentrations of lactate, glucose, maj...

journal_title：Placenta

authors： Serkova N,Bendrick-Peart J,Alexander B,Tissot van Patot MC

更新日期：2003-02-01 00:00:00

abstract：:Forkhead box O (FoxO) proteins regulate inflammation, extracellular matrix (ECM) remodelling and apoptosis. We have previously identified FoxO1 proteins in human gestational tissues, and demonstrated a link between FoxO1 and rupture of fetal membranes. There is, however, no data available on the expression and localis...

journal_title：Placenta

authors： Lappas M,Lim R,Riley C,Menon R,Permezel M

更新日期：2010-12-01 00:00:00

abstract：:Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...

journal_title：Placenta

authors： López Bernal A,Anderson AB,Turnbull AC

更新日期：1984-03-01 00:00:00

abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

journal_title：Placenta

authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

更新日期：2008-10-01 00:00:00

abstract：:Amnion is the innermost layer of the fetal membrane and has been suggested to regulate the volume of amniotic fluid via the amniotic epithelium. The transepithelial pathway is generally restricted by tight junctions (TJs). Thus far, human amniotic TJs have not been identified. In this study, we determined whether the ...

journal_title：Placenta

authors： Kobayashi K,Kadohira I,Tanaka M,Yoshimura Y,Ikeda K,Yasui M

更新日期：2010-02-01 00:00:00

abstract：:We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells ...

journal_title：Placenta

authors： Kameda T,Koyama M,Matsuzaki N,Taniguchi T,Saji F,Tanizawa O

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...

journal_title：Placenta

authors： David AL,Jauniaux E

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:The aim of this study is to determine whether the gene expression and associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived by assisted reproductive technologies (ART) compared to natural conceptions. METHODS:113 pregnancies were recruited resulting in 119 placentas (83 ...

journal_title：Placenta

authors： Sakian S,Louie K,Wong EC,Havelock J,Kashyap S,Rowe T,Taylor B,Ma S

更新日期：2015-10-01 00:00:00

abstract：:Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...

journal_title：Placenta

authors： Pongcharoen S,Somran J,Sritippayawan S,Niumsup P,Chanchan P,Butkhamchot P,Tatiwat P,Kunngurn S,Searle RF

更新日期：2007-01-01 00:00:00