Abstract:
:We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells and endothelial cells of fetal vessels, while Fc gamma RIII was expressed on trophoblasts, especially syncytiotrophoblasts. Moreover, we demonstrated that the expression of Fc gamma RI and Fc gamma RII on Hofbauer cells and endothelial cells of the fetal vessels in the 1st trimester placenta was different from that in the 3rd trimester placenta. These results, therefore, indicate that the three subtypes of Fc gamma R in the human placenta may contribute to maintenance of placental functions, because each Fc gamma R molecule displays unique biological functions similar to those on leukocytes.
journal_name
Placentajournal_title
Placentaauthors
Kameda T,Koyama M,Matsuzaki N,Taniguchi T,Saji F,Tanizawa Odoi
10.1016/0143-4004(91)90506-bsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
15-26issue
1eissn
0143-4004issn
1532-3102pii
0143-4004(91)90506-Bjournal_volume
12pub_type
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