Abstract：
:In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal cells and extracellular matrix proteins was observed in different zones of the stroma, the subamniotic stroma, Wharton's jelly, and the vessels' adventitia. All three zones showed immunoreactivities for collagen types I, III and VI and for basement membrane molecules such as collagen type IV, laminin and heparan sulphate proteoglycan. Immunoreactivities for these extracellular matrix molecules were observed around cleft-like territories (stromal clefts) in the Wharton's jelly which were occupied by homogeneous ground substance but void of collagen fibrils and basal lamina molecules. Moreover, between the stromal clefts, slender cells were found which immunohistochemically and ultrastructurally corresponded to various stages of myofibroblastic differentiation. In earlier stages of gestation, stromal cells with a less complex expression pattern prevailed. The stromal clefts and the contractile cells together might serve as a system regulating the turgor of the cord.
journal_name
Placentajournal_title
Placentaauthors
Nanaev AK,Kohnen G,Milovanov AP,Domogatsky SP,Kaufmann Pdoi
10.1016/s0143-4004(97)90071-0subject
Has Abstractpub_date
1997-01-01 00:00:00pages
53-64issue
1eissn
0143-4004issn
1532-3102pii
S0143-4004(97)90071-0journal_volume
18pub_type
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