当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Xanthine oxidase/dehydrogenase is present in human placenta.

Xanthine oxidase/dehydrogenase is present in human placenta.

Abstract：

:Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA probe for human XDH/XO and used it to detect mRNA by Northern hybridization. Immunohistochemical localization of the enzyme in placental tissue was performed using a specific antibody for XDH/XO and ABC-peroxidase. Enzyme activity assay was determined by the conversion of [14C] xanthine to [14C] uric acid. mRNA was detected in all placental samples (n = 4). Villous and non-villous trophoblast cells expressed immunohistochemical staining for XOD (n = 4). Enzyme activity was detected in all placentae (n = 6). Despite previous reports, we found mRNA, XDH/XO protein and enzyme activity in human placenta localized to trophoblast cells. Enzyme activity was much lower than in liver. Several conditions in the maternal-fetal unit could potentially increase XDH/XO activity and conversion of the enzyme to its oxidase form.

journal_name

Placenta

journal_title

Placenta

authors

Many A,Westerhausen-Larson A,Kanbour-Shakir A,Roberts JM

doi

10.1016/s0143-4004(96)90061-2

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

361-5

issue

5-6

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(96)90061-2

journal_volume

17

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Autophagy in placentas from acidotic newborns: an immunohistochemical study of LC3 expression.

    abstract：:Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining wit...

    journal_title：Placenta

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.placenta.2013.09.004

    authors： Avagliano L,Danti L,Doi P,Felis S,Guala M,Locatelli A,Maffeo I,Mecacci F,Plevani C,Simeone S,Bulfamante GP

    更新日期：2013-11-01 00:00:00

  • Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn.

    abstract：INTRODUCTION:Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.08.070

    authors： Herzog EM,Eggink AJ,Willemsen SP,Slieker RC,Wijnands KPJ,Felix JF,Chen J,Stubbs A,van der Spek PJ,van Meurs JB,Steegers-Theunissen RPM

    更新日期：2017-10-01 00:00:00

  • Calcitonin gene-related peptide receptor in human placental syncytiotrophoblast brush-border and basal plasma membranes.

    abstract：:Minerals, such as calcium and potassium, are essential for fetal development, but their transplacental transport, and in particular, the effect of hormones on this process has not been extensively studied. Human alpha-calcitonin gene-related peptide (h alpha CGRP), a hormone constituted of 37 amino acids, is obtained ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(97)90091-6

    authors： Lafond J,St-Pierre S,Masse A,Savard R,Simoneau L

    更新日期：1997-03-01 00:00:00

  • The assessment of gestational age and litter size in the guinea pig using a radiographic method.

    abstract：:The gestational age and litter size in the guinea pig can be accurately assessed by taking an x-ray of the animal. From a measurement of the fetal head length on the x-ray plate a fetal weight can be calculated using previously accumulated data, included here. The gestational age can be assessed from this weight to wi...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(82)80022-2

    authors： Thomas CR,Lowy C

    更新日期：1982-01-01 00:00:00

  • Epigenetic regulation of folate receptor-α (FOLR1) in human placenta of preterm newborns.

    abstract：INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.03.009

    authors： Piñuñuri R,Castaño-Moreno E,Llanos MN,Ronco AM

    更新日期：2020-05-01 00:00:00

  • Inconsistency of fetal trophoblast cells in first trimester maternal peripheral blood prevents non-invasive fetal testing using this cell target.

    abstract：:We have investigated whether maternal peripheral blood from the first trimester of pregnancy is a reliable source of identifiable trophoblast cells. The cells were enriched from 30 ml of venous blood, with multiple antibodies shown previously to enrich trophoblasts and a new cocktail based on known trophoblast surface...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0704

    authors： Schueler PA,Yamanishi DT,Pearson J,Lee Y,Wu X,Hashima S,Madlansacay MR,Cain CA,Collarini EJ,Foltz L,Mahoney W

    更新日期：2001-09-01 00:00:00

  • Placental pathology in congenital rubella.

    abstract：:Two groups of placentae from 18 cases of maternal rubella were examined morphologically and virologically. Placentae in Group I (four cases) had a mean gestational age of 21 +/- 1.9 weeks, whilst those in Group 2 (14 cases) had a mean gestational age of 38 +/- 2.8 weeks. A tendency to hypoplasia was observed. The micr...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(85)80038-2

    authors： Garcia AG,Marques RL,Lobato YY,Fonseca ME,Wigg MD

    更新日期：1985-07-01 00:00:00

  • Review: The role of autophagy in extravillous trophoblast function under hypoxia.

    abstract：:Autophagy, a process for cellular cleaning through the removal of intracellular components in lysosomes, is a well conserved mechanism from yeast to mammalian cells, and also contributes to the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodeling, and cellular defense aga...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2012.11.026

    authors： Saito S,Nakashima A

    更新日期：2013-03-01 00:00:00

  • Chronic villitis of unknown etiology and massive chronic intervillositis have similar immune cell composition.

    abstract：INTRODUCTION:Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic c...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.03.008

    authors： Labarrere CA,Hardin JW,Haas DM,Kassab GS

    更新日期：2015-06-01 00:00:00

  • Escherichia coli-induced temporal and differential secretion of heat-shock protein 70 and interleukin-1β by human fetal membranes in a two-compartment culture system.

    abstract：INTRODUCTION:Escherichia coli is recognized as an etiological bacteria associated with chorioamnionitis and the preterm premature rupture of fetal membranes. This pathological condition induces pro-inflammatory cytokines and degradative metalloproteinases, which are considered biological markers secreted in an acute st...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.12.011

    authors： Osorio-Caballero M,Perdigón-Palacio C,García-López G,Flores-Herrera O,Olvera-Sánchez S,Morales-Méndez I,Sosa-González I,Acevedo JF,Guzmán-Grenfell AM,Molina-Hernández A,Díaz NF,Flores-Herrera H

    更新日期：2015-03-01 00:00:00

  • Macroscopic and microscopic aspects of collared peccary and white-lipped peccary placenta.

    abstract：:This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.02.017

    authors： Santos TC,Dantzer V,Jones CJ,Oliveira MF,Miglino MA

    更新日期：2006-02-01 00:00:00

  • Trophoblast deportation part II: a review of the maternal consequences of trophoblast deportation.

    abstract：:The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology si...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2011.06.019

    authors： Pantham P,Askelund KJ,Chamley LW

    更新日期：2011-10-01 00:00:00

  • A systematic review of placental pathology in maternal diabetes mellitus.

    abstract：INTRODUCTION:During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported ...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2014.11.021

    authors： Huynh J,Dawson D,Roberts D,Bentley-Lewis R

    更新日期：2015-02-01 00:00:00

  • Differential apoptosis in BeWo cells after infection with highly (RH) or moderately (ME49) virulent strains of Toxoplasma gondii is related to the cytokine profile secreted, the death receptor Fas expression and phosphorylated ERK1/2 expression.

    abstract：INTRODUCTION:Alterations of apoptosis are commonly associated with pregnancy complications and abortion. Modulation of apoptosis is a relevant feature of Toxoplasma gondii infection and it is related to parasite strain types. The aim of the present study was to evaluate the possible factors that are involved in the dif...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.09.005

    authors： Angeloni MB,Guirelli PM,Franco PS,Barbosa BF,Gomes AO,Castro AS,Silva NM,Martins-Filho OA,Mineo TW,Silva DA,Mineo JR,Ferro EA

    更新日期：2013-11-01 00:00:00

  • The role of placental breast cancer resistance protein in the efflux of glyburide across the human placenta.

    abstract：:Gestational diabetes mellitus is a common medical complication in pregnancy. Recent findings demonstrate that glyburide is effluxed against a concentration gradient from the fetal to the maternal circulation. However, the transport systems involved in the active efflux of glyburide in the human placenta have not yet b...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.05.001

    authors： Pollex E,Lubetsky A,Koren G

    更新日期：2008-08-01 00:00:00

  • Establishment and characterization of a new human first trimester Trophoblast cell line, AL07.

    abstract：INTRODUCTION:The limited cell number of primary trophoblasts and contamination of trophoblast cell lines promote us to develop a novel stable trophoblast cell line. METHOD OF STUDY:Primary trophoblast cells were isolated from first-trimester placenta and telomerase-induced immortalization was used to immortalize these...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.08.013

    authors： Liu H,Wang L,Wang Y,Zhu Q,Aldo P,Ding J,Mor G,Liao A

    更新日期：2020-10-01 00:00:00

  • Investigation of the rate-limiting step in the synthesis of acetylcholine by the human placenta.

    abstract：:The uptake of [3H]choline and its conversion to [3H]acetylcholine were investigated in term human placental tissue in vitro. Although the net uptake of [3H]choline increased throughout a 45 min incubation period, intracellular [3H]choline levels reach a plateau after 2 min. There was a constant increase in [3H]acetylc...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(84)80036-3

    authors： Leventer SM,Rowell PP

    更新日期：1984-05-01 00:00:00

  • Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia.

    abstract：:Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.09.011

    authors： Zhao S,Gu Y,Dong Q,Fan R,Wang Y

    更新日期：2008-12-01 00:00:00

  • Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by pre-eclampsia and small for gestational age fetuses.

    abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0676

    authors： Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

    更新日期：2001-05-01 00:00:00

  • Expression and distribution of tight junction proteins in human amnion during late pregnancy.

    abstract：:Amnion is the innermost layer of the fetal membrane and has been suggested to regulate the volume of amniotic fluid via the amniotic epithelium. The transepithelial pathway is generally restricted by tight junctions (TJs). Thus far, human amniotic TJs have not been identified. In this study, we determined whether the ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.11.014

    authors： Kobayashi K,Kadohira I,Tanaka M,Yoshimura Y,Ikeda K,Yasui M

    更新日期：2010-02-01 00:00:00

  • Patterns of expression of Bax, Bcl-2 and Bcl-x(L) in the implantation site in rat during pregnancy.

    abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.09.008

    authors： Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

    更新日期：2005-11-01 00:00:00

  • Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system.

    abstract：INTRODUCTION:Perfluorinated alkyl acids (PFAAs) are widely used in industry and consumer products. Pregnant women are exposed to PFAAs and their presence in umbilical cord blood represents fetal exposure. Interestingly, PFAAs are substrates for organic anion transporters (OAT) of which OAT4 is expressed in human placen...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.07.119

    authors： Kummu M,Sieppi E,Koponen J,Laatio L,Vähäkangas K,Kiviranta H,Rautio A,Myllynen P

    更新日期：2015-10-01 00:00:00

  • Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta.

    abstract：BACKGROUND:Epigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of ca...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.06.371

    authors： Janssen BG,Byun HM,Cox B,Gyselaers W,Izzi B,Baccarelli AA,Nawrot TS

    更新日期：2014-09-01 00:00:00

  • Redness discordance in monochorionic twin placentas: Correlation with clinical and placental findings.

    abstract：INTRODUCTION/OBJECTIVES:Recent studies suggest redness (color) discordance of the placental basal plate may be a marker for twin anemia-polycythemia sequence (TAPS), a recently described complication of diamniotic-monochorionic twinning characterized by marked intertwin hemoglobin (Hb) discordance in the absence of oli...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.10.007

    authors： De Paepe ME,Gündoğan F,Mao Q,Chu S,Shapiro S

    更新日期：2017-12-01 00:00:00

  • Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta.

    abstract：INTRODUCTION:Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. MET...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.10.008

    authors： Gårdebjer EM,Cuffe JS,Pantaleon M,Wlodek ME,Moritz KM

    更新日期：2014-01-01 00:00:00

  • Placental oxygen consumption. Part II: in vitro studies--a review.

    abstract：:The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1053/plac.1999.0512

    authors： Schneider H

    更新日期：2000-03-01 00:00:00

  • Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes.

    abstract：OBJECTIVE:To estimate the utility of first-trimester 3D-placental volume and vascular flow indices in the prediction of adverse pregnancy outcomes. METHODS:A prospective cohort study including women with singleton pregnancies seen between 11 and 14 weeks as part of a screening program for aneuploidy. Placental volume ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.01.010

    authors： Odibo AO,Goetzinger KR,Huster KM,Christiansen JK,Odibo L,Tuuli MG

    更新日期：2011-03-01 00:00:00

  • Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels.

    abstract：:Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was tha...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)90002-9

    authors： Luckas MJ,Sandland R,Hawe J,Neilson JP,McFadyen IR,Meekins JW

    更新日期：1998-03-01 00:00:00

  • Increased apoptosis of human fetal membranes in rupture of the membranes and chorioamnionitis.

    abstract：:Apoptosis is thought to participate pathophysiologically in the rupture of human fetal membranes (ROM). The aim of this study was to assess apoptosis of the amnion and the chorion in relation to ROM and chorioamnionitis (CAM). The amnion and chorion at the position of the cervical os and fundus of the uterus were obta...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0776

    authors： Kataoka S,Furuta I,Yamada H,Kato EH,Ebina Y,Kishida T,Kobayashi N,Fujimoto S

    更新日期：2002-02-01 00:00:00

  • Apoptotic activity in villous trophoblast cells during B19 infection correlates with clinical outcome: assessment by the caspase-related M30 Cytodeath antibody.

    abstract：:Human parvovirus B19 (B19) infection during pregnancy can result in horizontal transmission of the virus and congenital infection. The main targets for B19 replication are the erythroid precursor cell of the colony and burst forming units. The cellular receptor necessary for B19 infectivity is globoside. Other non-ery...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0843

    authors： Jordan JA,Butchko AR

    更新日期：2002-08-01 00:00:00