Abstract:
:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatially dependent temporal control of apoptosis in these specific regions. To elucidate the role of the mitochondrion-dependent signalling pathway in tissue regression, we investigated the spatial and temporal pattern of expression of the Bcl-2 family members in uterine tissues of the implantation site, from the post-implantation period to parturition. Furthermore, the activities of the initiator caspases-8 and -9, and of the executioner caspase-3 were determined. Overall Bax and Bcl-2 were expressed from day 8 till day 19, whilst Bcl-x(L) was extinguished by day 16. In the antimesometrial and in the mesometrial decidua both Bcl-2 and Bax declined from days 10 to 12. In the latter Bcl-2 immunoreactivity decreased till the end of pregnancy, whilst for Bax a constant level remained thereafter. The pattern of variation of enzymatic activities throughout pregnancy for all the enzymes was similar, increasing from days 10 to 14 and decreasing towards the end of pregnancy. The increased levels of active caspase-9 correlated with Bax/Bcl-2 and Bcl-x(L) expression suggesting that the apoptotic mitochondrion-dependent pathway is involved in decidual regression during pregnancy progression.
journal_name
Placentajournal_title
Placentaauthors
Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NAdoi
10.1016/j.placenta.2004.09.008keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
796-806issue
10eissn
0143-4004issn
1532-3102pii
S0143-4004(04)00244-9journal_volume
26pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammat...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.09.015
更新日期:2013-12-01 00:00:00
abstract::The expression of apolipoprotein D (apo D), a lipocalin involved in defense mechanisms against oxidative stress, in placental tissue samples of pregnancies with gestational diabetes mellitus (GDM) was compared to non-diabetic controls. We have investigated the relationship of apo D with 4-HNE, a major propagation prod...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.002
更新日期:2010-01-01 00:00:00
abstract::Hyperplastic placentas have been reported in several experimental mouse models, including animals produced by somatic cell nuclear transfer, by inter(sub)species hybridization, and by somatic cytoplasm introduction to oocytes followed by intracytoplasmic sperm injection. Of great interest are the gross and histologica...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.05.008
更新日期:2008-08-01 00:00:00
abstract::Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.01.017
更新日期:2012-05-01 00:00:00
abstract::The walls of uterine spiral arteries are invaded by extravillous trophoblast cells and are thereby converted to the uteroplacental arteries of pregnancy. The mechanisms by which this invasion occurs are not understood, but the extracellular matrices that are breached suggest participation by specific proteinases. In t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80454-0
更新日期:1994-02-01 00:00:00
abstract::A localized intrauterine inflammatory response is often associated with the initiation of normal human parturition, whereas infection causes a similar but more florid response initiating preterm labor. Pre-B-cell colony-enhancing factor (PBEF) is expressed in the human fetal membranes and is up-regulated by labor, sev...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.03.011
更新日期:2007-04-01 00:00:00
abstract::Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(05)80638-1
更新日期:1996-01-01 00:00:00
abstract::This report compares the relative levels of messenger RNA species coding for plasma proteins in rat visceral yolk sac and fetal liver from 12.5 days to 21.5 days gestation. Transthyretin, retinol-binding protein, transferrin and alpha 1-fetoprotein mRNAs were detected in both tissues, although relative levels were muc...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80216-4
更新日期:1990-09-01 00:00:00
abstract::Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.01.020
更新日期:2007-01-01 00:00:00
abstract::Prior studies have shown that levels of corticotrophin-releasing hormone (CRH) in the umbilical cord blood of infants born after pregnancies complicated by pre-eclampsia are significantly higher than fetal plasma CRH concentrations in uncomplicated pregnancies. In the present study we have measured CRH by radioimmunoa...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(95)90095-0
更新日期:1995-06-01 00:00:00
abstract::Placental vascular tone is critically influenced by nitric oxide (NO) derived from endothelial NO synthase (eNOS) activity. Placental vessels from pregnancies complicated with intrauterine growth restriction present altered NOS-dependent vasodilation. Arginase-2 competes with eNOS for l-arginine and counteracts the NO...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.09.015
更新日期:2013-01-01 00:00:00
abstract::Confocal and conventional indirect immunofluorescence and immunogold electron microscopic methods were applied to examine the distribution of extracellular matrix constituents (collagens types III and IV) in the villi of immature and term human placentae. The immunofluorescence study revealed that collagen type III is...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(91)90493-y
更新日期:1991-11-01 00:00:00
abstract::Placentas and plasma from women with and without Chagas' disease and cultures of human placental villi with Trypanosoma cruzi, neuraminidase, phospholipase A2 and phospholipase C were analyzed in order to verify if the alterations in placental alkaline phosphatase (PLAP) enzyme activity are caused by T. cruzi as obser...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.08.014
更新日期:2005-11-01 00:00:00
abstract::Although secretory phospholipase A2 (PLA2) isozymes have been identified in human gestational tissues, their role in homeostasis and pathophysiology during pregnancy has yet to be clearly established. The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(98)90093-5
更新日期:1998-01-01 00:00:00
abstract::During early pregnancy, intermediate (extravillous) trophoblast infiltrates the basal plate and invades the spiral arteries, a physiological process required to establish the maternal-fetal circulation. Immunostaining studies have shown that differentiation of trophoblast into this invasive subpopulation is associated...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(02)90864-7
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.07.001
更新日期:2009-09-01 00:00:00
abstract::Intra-uterine growth restriction (IUGR) is defined by a restriction of fetal growth during gestation. It is a prevalent significant public health problem that jeopardizes neonatal health but also that can have deleterious consequences later in adult life. Cullins constitute a family of seven proteins involved in cell ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.008
更新日期:2010-02-01 00:00:00
abstract::Placental Site Trophoblastic Tumor (PSTT) is a rare form of Gestational Trophoblastic Disease (GTD). Approximately 200 cases have been reported in the literature. This disease has unpredictable biological behavior, whereas approximately 10-15% have clinically malignant evolution. We present the case of a 21-year old w...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.10.006
更新日期:2011-12-01 00:00:00
abstract::Paracellular pathways in the haemotrichorial placenta of the rat were studied by electron microscopy using lanthanum hydroxide as an electron dense marker. Near term placentae were dually perfused in situ, adding lanthanum to the fetal perfusate. In some placentae outflow pressure on the fetal side was elevated (betwe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0558
更新日期:2000-09-01 00:00:00
abstract::Theories on the development of placental pathologies and insufficiencies are based on the assumption that the development of the placental villous trees, the invasion of extravillous trophoblast or the differentiation of the villous trophoblast is somehow dysregulated. One of the pioneers trying to answer these questi...
journal_title:Placenta
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.placenta.2006.01.007
更新日期:2006-04-01 00:00:00
abstract::It has been suggested that adenosine is involved in the acute effects of ethanol in a number of tissues. The present study was undertaken to evaluate the role of adenosine on the vascular responses of perfused isolated human placental cotyledons after the acute administration of ethanol. The possibility that ethanol m...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80038-0
更新日期:1997-07-01 00:00:00
abstract::Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The meta...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2018.05.011
更新日期:2018-09-01 00:00:00
abstract::Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2003.11.011
更新日期:2004-07-01 00:00:00
abstract::The human placenta is capable of producing a variety of haematopoietic growth factors in vitro. It is not clear, however, whether the placenta produces such factors in vivo and if so, whether placental production of haematopoietic growth factors has a physiological role in fetal haematopoietic development. As a step t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(96)80079-8
更新日期:1996-11-01 00:00:00
abstract:INTRODUCTION:The limited cell number of primary trophoblasts and contamination of trophoblast cell lines promote us to develop a novel stable trophoblast cell line. METHOD OF STUDY:Primary trophoblast cells were isolated from first-trimester placenta and telomerase-induced immortalization was used to immortalize these...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.08.013
更新日期:2020-10-01 00:00:00
abstract::The localization of 5-hydroxytryptamine (5-HT) and its receptors in human placenta was studied under light and electron microscopy using immunohistochemistry and in situ hybridization. The syncytiotrophoblast, cytotrophoblast, stromal cells and decidual cells in human placentae all appeared to be 5-HT immunoreactive. ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90027-3
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.02.001
更新日期:2008-05-01 00:00:00
abstract::Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2008.08.007
更新日期:2008-10-01 00:00:00
abstract::Respiratory parameters were studied in mitochondria from human placenta. Respiratory control and ADP/O ratios were low in this preparation. The adenine nucleotide content of placental mitochondria was found to be only one quarter of that found for adult uterine muscle tissue mitochondria prepared in the same way. Load...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(85)80049-7
更新日期:1985-05-01 00:00:00
abstract:INTRODUCTION:The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.001
更新日期:2013-09-01 00:00:00