Abstract:
:Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk. The placenta plays a critical role in mediating nutritional signals between the fetus and the mother. As obesity rates in women of reproductive age continue to increase, it is becoming evident that inclusion of new technologies that allow for a better understanding of early changes in placental lipid transport and metabolism, non-invasively in maternal circulation, maternal tissues, placenta, fetal circulation and fetal tissues are needed to aid timely clinical diagnosis and treatment for obesity-associated diseases. This review describes pregnancy lipid homeostasis, with specific reference to changes arising from altered maternal body composition on placental and fetal lipid transport and metabolism. Current technologies for lipid assessments, such as metabolomics and lipidomics may be impacted by labour or mode of delivery and are only reflective of a single time point. This review further addresses how established and novel technologies for assessing lipids and their metabolism non-invasively and during the course of pregnancy may guide future research into the effect of maternal metabolic health on pregnancy outcome, placenta and fetus.
journal_name
Placentajournal_title
Placentaauthors
Delhaes F,Giza SA,Koreman T,Eastabrook G,McKenzie CA,Bedell S,Regnault TRH,de Vrijer Bdoi
10.1016/j.placenta.2018.05.011subject
Has Abstractpub_date
2018-09-01 00:00:00pages
118-124eissn
0143-4004issn
1532-3102pii
S0143-4004(18)30255-8journal_volume
69pub_type
杂志文章,评审相关文献
PLACENTA文献大全abstract::The morphometric oxygen diffusive conductance (D(p)) of the placenta provides a measure of the efficiency of oxygen transfer between the mother and the developing fetus. Any change in the D(p)may point towards possible adaptation in the light of altered oxygen transfer. Placentae from normal (n=40) and small for gesta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00044-4
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.12.006
更新日期:2016-02-01 00:00:00
abstract::The binding of oestradiol in human placental tissue obtained from spontaneous and caesarean deliveries was investigated. Villous tissue was homogenized and the 800 g 'cytosol' supernatant treated with ammonium sulphate. The precipitate was redissolved and the preparation then equilibrated with [3H]oestradiol. After se...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(85)80015-1
更新日期:1985-09-01 00:00:00
abstract:INTRODUCTION:To elucidate whether trophoblast expansion and invasion are modulated by androgen signaling in an in vitro co-culture model system with decidualizing endometrial stromal cells (ESCs). METHODS:We employed an in vitro co-culture model of early embryo implantation, consisting of human ESCs (EtsT499 cells) an...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.09.005
更新日期:2016-11-01 00:00:00
abstract::Maternal-to-fetal transmission of the murine lactate dehydrogenase-elevating virus (LDV) has been previously shown to be regulated by maternal immunity as well as gestational age. For the present study, the role of maternal immunity in placental and umbilical cord virus protection was studied, and virus targeting of u...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0829
更新日期:2002-05-01 00:00:00
abstract::Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0774
更新日期:2002-02-01 00:00:00
abstract::Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.008
更新日期:2015-12-01 00:00:00
abstract::The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investig...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.04.018
更新日期:2011-08-01 00:00:00
abstract:INTRODUCTION:Preterm birth is a heterogeneous phenotype, with placental abnormalities underlying many cases. The etiology of preterm births that occur in the absence of placental abnormalities, however, remain enigmatic and we considered that early pregnancy biomarkers may provide clues. METHODS:Women from a hospital-...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.12.007
更新日期:2020-01-01 00:00:00
abstract::Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.01.017
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.001
更新日期:2013-09-01 00:00:00
abstract::Placental ultrasonographic, bio- and histochemical studies were performed on four unrelated fetuses affected with Niemann-Pick disease Type A, following prostaglandin-induced abortion at about the 19th week of gestation. An accumulation of sphingomyelin in the placentae of affected fetuses indicates the essential role...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(85)80030-8
更新日期:1985-01-01 00:00:00
abstract:INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.10.016
更新日期:2013-01-01 00:00:00
abstract::The clinical features of the maternal syndrome of pre-eclampsia can be explained by generalised maternal endothelial cell dysfunction, which is a part of a more global maternal systemic inflammatory response. There is growing evidence that these effects are associated with the shedding of cellular debris, including sy...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.08.018
更新日期:2008-11-01 00:00:00
abstract::Pregnancy induces a number of alterations to maternal physiology to accommodate the increased demands made by the developing fetus and placenta. These alterations appear at least in part to be driven by products derived from the feto-placental unit, including microchimeric cells, as well as placental exosomes and micr...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.11.005
更新日期:2012-02-01 00:00:00
abstract::Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the pres...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.02.004
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. MET...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.10.008
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.05.010
更新日期:2015-08-01 00:00:00
abstract::Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.09.011
更新日期:2008-12-01 00:00:00
abstract::Gestational diabetes mellitus is a common medical complication in pregnancy. Recent findings demonstrate that glyburide is effluxed against a concentration gradient from the fetal to the maternal circulation. However, the transport systems involved in the active efflux of glyburide in the human placenta have not yet b...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.05.001
更新日期:2008-08-01 00:00:00
abstract::This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0676
更新日期:2001-05-01 00:00:00
abstract::Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2003.09.002
更新日期:2004-02-01 00:00:00
abstract::The hormone leptin (OB) and its receptor (OB-R) are key homeostatic regulators of mammalian body weight. Two predominant isoforms of OB-R are expressed by alternative splicing: the long form, OB-RL, with full signalling capacity is highly expressed in the hypothalamus and the short, signalling-defective form, OB-Rs, i...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0836
更新日期:2002-07-01 00:00:00
abstract::Amnion is the innermost layer of the fetal membrane and has been suggested to regulate the volume of amniotic fluid via the amniotic epithelium. The transepithelial pathway is generally restricted by tight junctions (TJs). Thus far, human amniotic TJs have not been identified. In this study, we determined whether the ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.014
更新日期:2010-02-01 00:00:00
abstract::An area of the fetal membranes, within the rupture tear after spontaneous delivery at term, exhibits altered morphology compared to more distal sites. It is characterized by marked swelling of the amniotic and chorionic connective tissue layers, consistent with structural weakness, and a marked reduction of the thickn...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0439
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Research suggests that autism spectrum disorder (ASD) has its origins in utero. This study examines the association between evidence of placental histopathology and ASD. METHODS:Administrative claims data and medical records data were used to identify ASD cases (N = 55) and matched controls (N = 199) born...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.07.006
更新日期:2017-09-01 00:00:00
abstract::Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.01.020
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To study the association between velamentous cord insertion (VCI) and different outcomes in monochorionic twins with and without twin-twin transfusion syndrome (TTTS). METHODS:We recorded the cord insertion type in all consecutive monochorionic placentas examined in two tertiary medical centers. The associat...
journal_title:Placenta
pub_type: 杂志文章,多中心研究
doi:10.1016/j.placenta.2013.08.009
更新日期:2013-11-01 00:00:00
abstract::Long-chain polyunsaturated fatty acids (LCPUFAs) such as docosahexaenoic acid (DHA) and arachidonic acid (AA) are essential for proper development of fetal brain and retina. These LCPUFAs are selectively enriched in the fetal circulation compared with the maternal circulation. In the current study we investigated the ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.10.007
更新日期:2009-01-01 00:00:00
abstract::The central role of the placenta in the pathogenesis of pre-eclampsia is undisputed. The evidence that maternal syndrome of pre-eclampsia is caused by a maternal systemic inflammatory response (MSIR) is reviewed. The polymorphic nature of the inflammatory network explains the diversity of the varied signs of this cond...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1053/plac.2002.0930
更新日期:2003-04-01 00:00:00