Abstract:
:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiogenic cells differentiate to form first vessels. These progenitor cells are thought to be directly derived from mesenchymal cells rather than originating from fetal blood cells. We investigated the relation between differentiation of stromal cells towards endothelial cells and vascular structures and the expression pattern of the respective growth factors. Using transmission electron microscopy and immunohistochemistry (for VEGF, Flt-1, Flk-1, CD14, CD34, and CD68) the development of placental vasculogenesis during very early stages of pregnancy (days 22-48 p.c.) was studied. We found that VEGF is strongly expressed in villous cytotrophoblast cells and subsequently in Hofbauer cells while its receptors Flt-1 and Flk-1 are found on vasculogenic and angiogenic precursor cells. The developmental expression and secretion of VEGF suggests its involvement in recruitment, maintenance and formation of first angiogenic cells and vessels. Interactions between VEGF and Flk-1 and Flt-1 may regulate placental vasculogenesis and angiogenesis in a paracrine and autocrine manner. The sequential expression of growth factors in different cell types may point to the fact that placental vasculogenesis and angiogenesis are clearly distinct events.
journal_name
Placentajournal_title
Placentaauthors
Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz Bdoi
10.1016/j.placenta.2003.11.011keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
560-72issue
6eissn
0143-4004issn
1532-3102pii
S014340040300314Xjournal_volume
25pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Sections of human term placentae delivered at low and high altitude to indigenous and non-indigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indic...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90067-7
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.12.006
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Placenta previa is a severe pregnancy complication with considerable maternal and neonatal morbidity. Placenta previa can be defined as major or minor by location. Major placenta previa is associated with higher complication rates. Management of women with minor placenta previa has not been well defined. T...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.08.080
更新日期:2019-09-15 00:00:00
abstract:INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.002
更新日期:2013-07-01 00:00:00
abstract::Although secretory phospholipase A2 (PLA2) isozymes have been identified in human gestational tissues, their role in homeostasis and pathophysiology during pregnancy has yet to be clearly established. The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(98)90093-5
更新日期:1998-01-01 00:00:00
abstract::Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(96)90061-2
更新日期:1996-07-01 00:00:00
abstract::Oestrogen and progesterone receptors have been implicated in human placental steroidogenesis, but studies developed to measure their concentration in this tissue at term yielded discrepant results. Potential inaccuracy of the binding assays, the technique used in previous studies, might influence the discrepancy. In t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(89)90049-0
更新日期:1989-11-01 00:00:00
abstract::Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.11.005
更新日期:2015-01-01 00:00:00
abstract::Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1053/plac.1999.0515
更新日期:2000-03-01 00:00:00
abstract:INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder unique to pregnancy that is associated with increased rates of fetal distress and demise. While acute hypoxia is believed to cause the pathophysiology of ICP, direct molecular evidence for this is lacking. Here, we analyzed expression of three...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.06.372
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. METHODS:In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler u...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.12.014
更新日期:2020-01-15 00:00:00
abstract::The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.09.001
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.001
更新日期:2013-09-01 00:00:00
abstract::Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been associated with pregnancy disorders, such as recurrent miscarriages, intrauterine growth retardation, and pre-eclampsia. The aim of this study was t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.07.012
更新日期:2009-10-01 00:00:00
abstract:INTRODUCTION:Preeclampsia is a severe pregnancy complication mostly due to inadequate vascular dilation and remodeling of spiral arteries. VEGF, the major factor for angiogenesis, is necessary for modulating angiogenic processes in the placenta. Hence reduction of VEGF in gestational hypertension may also lead to hypop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.08.088
更新日期:2016-10-01 00:00:00
abstract::The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.09.008
更新日期:2005-11-01 00:00:00
abstract::Homogenates of first (10.1 +/- 1.0 weeks) and third trimester placental villi were analysed for free amino acid concentrations. As has been previously reported, several amino acids showed increased concentrations during early pregnancy when compared to term. In addition, marked differences were seen in the levels of e...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(94)90037-x
更新日期:1994-10-01 00:00:00
abstract::A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from sever...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90052-x
更新日期:1987-05-01 00:00:00
abstract::Placental pathology is a valuable link explaining how underlying pregnancy risk factors result in adverse pregnancy outcome. This potentially useful information is currently underutilized due to a general lack of rigor in placental diagnosis. This lack of rigor is in large part due to a failure to appreciate the impor...
journal_title:Placenta
pub_type:
doi:10.1016/j.placenta.2005.02.009
更新日期:2005-04-01 00:00:00
abstract::The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1998.0366
更新日期:1999-03-01 00:00:00
abstract::We investigated whether histological evidence of early atherosclerosis was present in the umbilical artery of 21 pregnancies complicated by severe perinatal inflammation, and 21 controls matched for gestational age, sex and birth weight. Severe chorioamnionitis with funisitis was associated with increased numbers of C...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.12.021
更新日期:2017-02-01 00:00:00
abstract::Apoptosis is thought to participate pathophysiologically in the rupture of human fetal membranes (ROM). The aim of this study was to assess apoptosis of the amnion and the chorion in relation to ROM and chorioamnionitis (CAM). The amnion and chorion at the position of the cervical os and fundus of the uterus were obta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0776
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.01.004
更新日期:2015-04-01 00:00:00
abstract::Theories on the development of placental pathologies and insufficiencies are based on the assumption that the development of the placental villous trees, the invasion of extravillous trophoblast or the differentiation of the villous trophoblast is somehow dysregulated. One of the pioneers trying to answer these questi...
journal_title:Placenta
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.placenta.2006.01.007
更新日期:2006-04-01 00:00:00
abstract::Antigen expression by villous and extravillous human trophoblast populations at discrete anatomical sites has been reviewed. The various different antigenic phenotypes have been highlighted using a panel of monoclonal antibodies reactive with characteristic trophoblast membrane antigens, a trophoblast-leucocyte common...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(85)80063-1
更新日期:1985-03-01 00:00:00
abstract::Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2008.08.007
更新日期:2008-10-01 00:00:00
abstract::Pregnancy-specific beta 1-glycoprotein (Schwangerschaftsprotein, SP1) is elevated in the amniotic fluid in Meckel's syndrome. In an attempt to clarify this phenomenon, we studied fetal tissues by immunohistochemistry for the distribution of SP1 in normal fetuses and fetuses with Meckel's syndrome. The amount of SP1 wa...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90070-1
更新日期:1987-07-01 00:00:00
abstract::As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are lik...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2018.01.002
更新日期:2018-09-01 00:00:00
abstract::In view of the pathological placental features of pre-eclampsia and intrauterine growth restriction (IUGR), and the angiogenic effects of vascular endothelial growth factor (VEGF), the aim of this study was to determine the expression of VEGF in placentae from normal pregnancies and to compare the results with placent...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80061-6
更新日期:1997-05-01 00:00:00
abstract::Placentae from normal term pregnancies, from "normal" preterm pregnancies and from pregnancies complicated by pre-eclampsia have been analysed by computerized histometry. An immunoperoxidase technique was used to stain specifically human placental lactogen in the syncytiotrophoblast. The percentage and mass of syncyti...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80004-6
更新日期:1983-07-01 00:00:00