Studies on the localization of 5-hydroxytryptamine and its receptors in human placenta.

abstract：:The EAT/mcl-1 gene was isolated during the early differentiation of a retinoic acid-induced human embryonal carcinoma cell line to the trophectoderm lineage. EAT/mcl-1, a bcl-2 related gene, is involved in the genetic pathway of apoptosis; this suggests a role for apoptosis and the involvement of this gene in early pl...

journal_title：Placenta

authors： Suzuki A,Umezawa A,Sano M,Nozawa S,Hata J

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their behavior may partly unde...

journal_title：Placenta

authors： Morales-Prieto DM,Chaiwangyen W,Ospina-Prieto S,Schneider U,Herrmann J,Gruhn B,Markert UR

更新日期：2012-09-01 00:00:00

abstract：:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...

journal_title：Placenta

authors： Dilworth MR,Kusinski LC,Baker BC,Renshall LJ,Baker PN,Greenwood SL,Wareing M,Sibley CP

更新日期：2012-12-01 00:00:00

abstract：:When cultured in keratinocyte growth medium, mononuclear cytotrophoblast cells aggregate into multicellular colonies which then fuse to form multinucleated syncytiotrophoblast. In an attempt to characterize better the mechanism of human trophoblast differentiation and to obtain information about the role of the cytosk...

journal_title：Placenta

authors： Douglas GC,King BF

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...

journal_title：Placenta

authors： Bose P,Kadyrov M,Goldin R,Hahn S,Backos M,Regan L,Huppertz B

更新日期：2006-08-01 00:00:00

abstract：:Human parvovirus B19 (B19) infection during pregnancy can result in horizontal transmission of the virus and congenital infection. The main targets for B19 replication are the erythroid precursor cell of the colony and burst forming units. The cellular receptor necessary for B19 infectivity is globoside. Other non-ery...

journal_title：Placenta

authors： Jordan JA,Butchko AR

更新日期：2002-08-01 00:00:00

abstract：:This study was based on the hypothesis that both primary sequence and methylation status of the GTPase activating protein (GAP) gene limits expression of p100 GAP to primate placenta. Due to alternate splicing, a 65-bp insert appears between the first and second coding exons of p100 GAP mRNA, and translation of p100 G...

journal_title：Placenta

authors： Liao L,Trouba KJ,Vorce RL

更新日期：1998-03-01 00:00:00

abstract：INTRODUCTION:We have identified some critical aspects concerning umbilical cord tissue mesenchymal stem cells: the lack of standards for cell isolation, expansion and cryopreservation, the lack of unanimous opinions upon their multilineage differentiation potential and the existence of very few results related to the f...

journal_title：Placenta

authors： Dulugiac M,Moldovan L,Zarnescu O

更新日期：2015-10-01 00:00:00

abstract：:Placentae from both smoking and non-smoking mothers were studied with respect to P450-dependent xenobiotic and steroid-metabolizing reactions, GSHt activity with different substrates and umbilical blood cotinine levels. Catalytic activities were determined in both freshly prepared homogenate subfractions and subfracti...

journal_title：Placenta

authors： Pasanen M,Pelkonen O

更新日期：1990-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) and its homologue, transforming growth factor-alpha (TGF-alpha), regulate human chorionic gonadotropin (hCG) synthesis in the human placenta. The current study was designed to investigate the involvement of the protein kinase C pathway in EGF-mediated hCG-beta production by JAr choriocarc...

journal_title：Placenta

authors： Baker VL,Murai JT,Taylor RN

更新日期：1998-09-01 00:00:00

abstract：:Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...

journal_title：Placenta

authors： Kikkawa F,Shibata K,Suzuki T,Kajiyama H,Ino K,Nomura S,Mizutani S

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....

journal_title：Placenta

authors： Morosin SK,Delforce SJ,Lumbers ER,Pringle KG

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that pregnancies complicated by placentas with an isolated single umbilical artery (iSUA) are at increased risk for small-for-gestational-age (SGA) births. The etiology of SGA in this population, however, remains unknown. OBJECTIVE:The primary objective of this study was to evalu...

journal_title：Placenta

authors： Battarbee AN,Palatnik A,Ernst LM,Grobman WA

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Increasing evidence suggests an association between periodontal disease and low birthweight (LBW); however the underlying molecular mechanisms are yet to be fully elucidated. In this study, we performed a microarray analysis to observe the human placental trophoblast-like BeWo cells response to lipopolysaccha...

journal_title：Placenta

authors： Li Y,Shibata Y,Zhang L,Kuboyama N,Abiko Y

更新日期：2011-01-01 00:00:00

abstract：:Indiscriminate invasion upon the endometrium by normal trophoblasts is strictly regulated unlike that by choriocarcinoma cells. In this study, we focused on the activity of matrix metalloproteinase (MMP)-2 and MMP-9 as parameters of invasion in normal human placenta. In situ hybridization (ISH), immunohistochemical st...

journal_title：Placenta

authors： Isaka K,Usuda S,Ito H,Sagawa Y,Nakamura H,Nishi H,Suzuki Y,Li YF,Takayama M

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...

journal_title：Placenta

authors： David AL,Jauniaux E

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To gain insight into the process of labor and the effects of labor on placental gene expression, we performed a microarray analysis to identify the differentially expressed transcripts that may participate in labor onset and progression. METHODS:We compared expression profiles in placentas from 16 women who...

journal_title：Placenta

authors： Lee KJ,Shim SH,Kang KM,Kang JH,Park DY,Kim SH,Farina A,Shim SS,Cha DH

更新日期：2010-08-01 00:00:00

abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...

journal_title：Placenta

authors： Duncan JR,Cock ML,Rees S,Harding R

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...

journal_title：Placenta

authors： Allsopp R,Shimoda J,Easa D,Ward K

更新日期：2007-04-01 00:00:00

abstract：:Dietary taurine is essential for cats and deficiency during pregnancy may lead to abortion, growth restriction or impaired neurological function of kittens. We previously described Na(+)- and Cl(-)-dependent taurine transport by system beta in fragments of freshly isolated cat placenta [Champion EE, Bailey SJ, Glazier...

journal_title：Placenta

authors： Champion EE,Mann SJ,Glazier JD,Jones CJ,Rawlings JM,Sibley CP,Greenwood SL

更新日期：2005-09-01 00:00:00

abstract：:The walls of uterine spiral arteries are invaded by extravillous trophoblast cells and are thereby converted to the uteroplacental arteries of pregnancy. The mechanisms by which this invasion occurs are not understood, but the extracellular matrices that are breached suggest participation by specific proteinases. In t...

journal_title：Placenta

authors： Blankenship TN,King BF

更新日期：1994-02-01 00:00:00

abstract：:Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Now, more than half a century later, it is well understood that with the initiation of pregnancy, immune cel...

journal_title：Placenta

authors： Hunt JS,Petroff MG

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

journal_title：Placenta

authors： Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...

journal_title：Placenta

authors： Salafia CM,Yampolsky M,Shlakhter A,Mandel DH,Schwartz N

更新日期：2012-03-01 00:00:00

abstract：:We have derived a cell line, RE1, from a pre-implantation rat blastocyst, resembling morphologically the L2 cell line from a parietal yolk sac carcinoma of the rat, as well as parietal endoderm cell lines of the mouse. The sub-cellular organization and epithelial characteristics of RE1 cells are described. The cells e...

journal_title：Placenta

authors： Notarianni E,Fléchon J

更新日期：2001-01-01 00:00:00

abstract：:Neuropeptides play an important role in the regional regulation of blood flow and hormone secretion. Few studies report the presence of peptides in the human placenta. Our experiment evaluates neuropeptides in the human placenta using immunocytochemical techniques. Representative tissue sections from full-term placent...

journal_title：Placenta

authors： Graf AH,Hütter W,Hacker GW,Steiner H,Anderson V,Staudach A,Dietze O

更新日期：1996-09-01 00:00:00

abstract：:The present study was designed to localize some important enzymes, such as adenosine diphospate-degrading enzyme (ADP-degrading enzyme) (plasma membrane enzyme), cytochrome c oxidase (mitochondrial enzyme) and glucose-6-phosphatase (endoplasmic reticulum enzyme), in placentae from patients with idiopathic fetal growth...

journal_title：Placenta

authors： Matsubara S,Sato I

更新日期：2000-03-01 00:00:00

abstract：:The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...

journal_title：Placenta

authors： Conrad KP,Davis AK

更新日期：1995-12-01 00:00:00

abstract：:Bovine nuclear transfer pregnancies are characterized by a high incidence of placental abnormalities, notably, increased placentome size and deficiencies in trophoblast cell function and establishment of placental vasculature. Alterations in gene expression during placental growth and development may contribute to the...

journal_title：Placenta

authors： Ravelich SR,Shelling AN,Wells DN,Peterson AJ,Lee RS,Ramachandran A,Keelan JA

更新日期：2006-02-01 00:00:00

abstract：:During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia Inducible Factors (HIF) are t...

journal_title：Placenta

authors： Patel J,Landers K,Mortimer RH,Richard K

更新日期：2010-11-01 00:00:00