Abstract:
:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were no more growth restricted than those with P0 deletion alone. However, P0 deletion attenuated the reduced placental system A amino acid transporter activity previously observed in eNOS(-/-) mice. Manipulating maternal and fetal genotypes provides a means to compare maternal and fetal regulation of fetal growth.
journal_name
Placentajournal_title
Placentaauthors
Dilworth MR,Kusinski LC,Baker BC,Renshall LJ,Baker PN,Greenwood SL,Wareing M,Sibley CPdoi
10.1016/j.placenta.2012.09.012subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1052-4issue
12eissn
0143-4004issn
1532-3102pii
S0143-4004(12)00359-1journal_volume
33pub_type
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