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Placental cell release of transferrin: analysis by reverse haemolytic plaque assay.

Abstract：

:Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development. In this study, we first confirmed these findings using cRNA probes for TF, and then adapted the TF reverse haemolytic plaque assay for use with rat placental cells to identify the location and functional characteristics of cells secreting this product. We found TF releasing cells in placentae (day 19-21) with greater proportions present in cultures from basal than labyrinth zone regions. These cells appeared quite stable as evidenced by observations that fresh populations and 24, 48 and 72 h cultures from the same placental regions all contained similar percentages of secretors. The rate of TF plaque formation was greatly enhanced in the presence of tumour necrosis factor (0.1 ng/ml) for basal zone and yolk sac cells, but not for labyrinth zone cells, suggesting a potent but regionally specific modulation of TF release. When taken together, these findings demonstrate clearly that TF is released from cells of the placenta. Moreover, the regional differences in frequency and modulation of these cells suggests that the release of placental TF is a dynamic and carefully controlled process.

journal_name

Placenta

journal_title

Placenta

authors

Boockfor FR,Harris SE,Barto JM,Bonner JM

doi

10.1016/s0143-4004(05)80419-9

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

501-9

issue

5

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(05)80419-9

journal_volume

15

pub_type

杂志文章

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