当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Periodontal pathogen Aggregatibacter actinomycetemcomitans LPS induces mitochondria-dependent-apoptosis in human placental trophoblasts.

Periodontal pathogen Aggregatibacter actinomycetemcomitans LPS induces mitochondria-dependent-apoptosis in human placental trophoblasts.

Abstract：

OBJECTIVE:Increasing evidence suggests an association between periodontal disease and low birthweight (LBW); however the underlying molecular mechanisms are yet to be fully elucidated. In this study, we performed a microarray analysis to observe the human placental trophoblast-like BeWo cells response to lipopolysaccharide (LPS) from periodontopathogen Aggregatibacter actinomycetemcomitans (Aa), in order to investigate the molecular basis of mechanisms for periodontitis-associated LBW. In vivo pregnant rats were also used to confirm the in vitro results. STUDY DESIGN:The effects of Aa-LPS on cultured human placental trophoblast-like BeWo cells were studied using a DNA microarray, Ingenuity Pathway Analysis, real-time PCR and poly-caspase staining. The in vivo effects of Aa-LPS in pregnant rats were examined using TUNEL assays. RESULTS:In BeWo cells, Aa-LPS increased levels of cytochrome c, caspase 2, caspase 3, caspase 9 and BCL2-antagonist/killer 1 mRNA, decreased those of B-cell CLL/lymphoma 2, BCL2-like 1 and catalase mRNA and increased poly-caspase activity, all of which are consistent with activation of the mitochondria-dependent apoptotic pathway. TUNEL assays confirmed the increased incidence of apoptosis in placentas of Aa-LPS-treated rats (p < 0.001). CONCLUSION:Aa-LPS induces apoptosis in human trophoblasts via the mitochondria-dependent pathway, and this effect may contribute to the pathogenesis of periodontitis-associated LBW.

journal_name

Placenta

journal_title

Placenta

authors

Li Y,Shibata Y,Zhang L,Kuboyama N,Abiko Y

doi

10.1016/j.placenta.2010.10.007

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

11-9

issue

1

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(10)00385-1

journal_volume

32

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor.

    abstract：:Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the pres...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.02.004

    authors： von Versen-Höynck F,Rajakumar A,Bainbridge SA,Gallaher MJ,Roberts JM,Powers RW

    更新日期：2009-05-01 00:00:00

  • The effects of repeated endotoxin exposure on placental structure in sheep.

    abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(03)00104-8

    authors： Duncan JR,Cock ML,Rees S,Harding R

    更新日期：2003-08-01 00:00:00

  • The evolving placenta: convergent evolution of variations in the endotheliochorial relationship.

    abstract：:Endotheliochorial placentas occur in orders from all four major clades of eutherian mammal. Species with this type of placenta include one of the smallest (pygmy shrew) and largest (African elephant) land mammals. The endotheliochorial placenta as a definitive form has an interhemal area consisting of maternal endothe...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2012.02.008

    authors： Enders AC,Carter AM

    更新日期：2012-05-01 00:00:00

  • The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia.

    abstract：:The clinical features of the maternal syndrome of pre-eclampsia can be explained by generalised maternal endothelial cell dysfunction, which is a part of a more global maternal systemic inflammatory response. There is growing evidence that these effects are associated with the shedding of cellular debris, including sy...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.08.018

    authors： Reddy A,Zhong XY,Rusterholz C,Hahn S,Holzgreve W,Redman CW,Sargent IL

    更新日期：2008-11-01 00:00:00

  • Maternal obesity and sex-specific differences in placental pathology.

    abstract：OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.12.006

    authors： Leon-Garcia SM,Roeder HA,Nelson KK,Liao X,Pizzo DP,Laurent LC,Parast MM,LaCoursiere DY

    更新日期：2016-02-01 00:00:00

  • The Elsevier Trophoblast Research Award Lecture: Importance of metzincin proteases in trophoblast biology and placental development: a focus on ADAM12.

    abstract：:Placental development is a highly regulated process requiring signals from both fetal and maternal uterine compartments. Within this complex system, trophoblasts, placental cells of epithelial lineage, form the maternal-fetal interface controlling nutrient, gas and waste exchange. The commitment of progenitor villous ...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2014.12.016

    authors： Aghababaei M,Beristain AG

    更新日期：2015-04-01 00:00:00

  • Mononuclear phagocytes in the human placenta.

    abstract：:Hofbauer cells have been identified by morphological criteria in human placentae and are considered to be mononuclear phagocytes. An increasing recognition of the morphological heterogeneity of mononuclear phagocytes and of the considerable difficulty in their recognition in histological sections has suggested that th...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(80)80019-1

    authors： Wood GW

    更新日期：1980-04-01 00:00:00

  • Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases.

    abstract：BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study exam...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.10.009

    authors： Dubruc E,Lebreton F,Giannoli C,Rabilloud M,Huissoud C,Devouassoux-Shisheboran M,Allias F

    更新日期：2016-12-01 00:00:00

  • The increased endotoxin-sensitivity of pregnant rats, as reflected by glomerular ecto-ADP-ase activity, is not dependent on the presence of decidual cells.

    abstract：:In the present study the possible role of decidual cells in the pregnancy-associated increased sensitivity of glomerular ecto-ADP-ase to endotoxin was investigated. Early (day 5) pregnant (E-Pr; n = 10), pseudopregnant (E-PSP; n = 10), (day 5), pseudopregnant rats with a decidualized uterus (E-DEC; n - 10), as well as...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(96)80013-0

    authors： Faas MM,Schuiling GA,Baller JF,Valkhof N,Bakker WW

    更新日期：1996-03-01 00:00:00

  • Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels.

    abstract：:Placental vascular tone is critically influenced by nitric oxide (NO) derived from endothelial NO synthase (eNOS) activity. Placental vessels from pregnancies complicated with intrauterine growth restriction present altered NOS-dependent vasodilation. Arginase-2 competes with eNOS for l-arginine and counteracts the NO...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.09.015

    authors： Krause BJ,Carrasco-Wong I,Caniuguir A,Carvajal J,Farías M,Casanello P

    更新日期：2013-01-01 00:00:00

  • ED(27) trophoblast-like cells isolated from first-trimester chorionic villi are genetically identical to HeLa cells yet exhibit a distinct phenotype.

    abstract：:ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0749

    authors： Kniss DA,Xie Y,Li Y,Kumar S,Linton EA,Cohen P,Fan-Havard P,Redman CW,Sargent IL

    更新日期：2002-01-01 00:00:00

  • Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells.

    abstract：:Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2003.09.002

    authors： Kikkawa F,Shibata K,Suzuki T,Kajiyama H,Ino K,Nomura S,Mizutani S

    更新日期：2004-02-01 00:00:00

  • Current topic: interferon and human placental development.

    abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(05)80220-6

    authors： Loke YW,King A

    更新日期：1990-07-01 00:00:00

  • Oestrogen and progesterone receptors in human term placenta. Measurement by binding assays and immunological methods.

    abstract：:Oestrogen and progesterone receptors have been implicated in human placental steroidogenesis, but studies developed to measure their concentration in this tissue at term yielded discrepant results. Potential inaccuracy of the binding assays, the technique used in previous studies, might influence the discrepancy. In t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(89)90049-0

    authors： Rivera J,Cano A

    更新日期：1989-11-01 00:00:00

  • Placental morphology: from molecule to mother -- a dedication to Peter Kaufmann -- a review.

    abstract：:Theories on the development of placental pathologies and insufficiencies are based on the assumption that the development of the placental villous trees, the invasion of extravillous trophoblast or the differentiation of the villous trophoblast is somehow dysregulated. One of the pioneers trying to answer these questi...

    journal_title：Placenta

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1016/j.placenta.2006.01.007

    authors： Huppertz B,Burton G,Cross JC,Kingdom JC

    更新日期：2006-04-01 00:00:00

  • Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestation.

    abstract：INTRODUCTION:Decidual leukocytes are critical to the development of the fetomaternal interface, regulating tolerance to the semi-allogeneic fetus and vascular transformation of the uterine spiral arteries. Despite the continuation of these processes beyond the first trimester of pregnancy, the second trimester has larg...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.09.018

    authors： Kwan M,Hazan A,Zhang J,Jones RL,Harris LK,Whittle W,Keating S,Dunk CE,Lye SJ

    更新日期：2014-12-01 00:00:00

  • Accelerated expression of Ca antigen by placental villous trophoblast in pre-eclampsia.

    abstract：:The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(05)80194-8

    authors： Bishop PW,Malam JE,Morris JA,Fox H

    更新日期：1990-11-01 00:00:00

  • Endoplasmic reticulum stress is induced in the human placenta during labour.

    abstract：:Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.11.005

    authors： Veerbeek JH,Tissot Van Patot MC,Burton GJ,Yung HW

    更新日期：2015-01-01 00:00:00

  • Alphafetoprotein and alphafetoprotein receptor expression in the normal human placenta at term.

    abstract：:Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP recept...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.06.005

    authors： Newby D,Dalgliesh G,Lyall F,Aitken DA

    更新日期：2005-02-01 00:00:00

  • Review: hCGs: different sources of production, different glycoforms and functions.

    abstract：:Human chorionic gonadotropin (hCG) is the first hormonal message from the placenta to the mother. It is detectable in maternal blood two days after implantation and behaves like an agonist of LH stimulating progesterone secretion by the corpus luteum. hCG has also a role in quiescence of the myometrium and local immun...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2015.02.002

    authors： Fournier T,Guibourdenche J,Evain-Brion D

    更新日期：2015-04-01 00:00:00

  • Classics revisited: C. J. van der Horst on pregnancy and menstruation in elephant shrews.

    abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

    journal_title：Placenta

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1016/j.placenta.2018.05.010

    authors： Carter AM

    更新日期：2018-07-01 00:00:00

  • Maternal uterine artery VEGF gene therapy for treatment of intrauterine growth restriction.

    abstract：:Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2017.09.011

    authors： David AL

    更新日期：2017-11-01 00:00:00

  • All-trans-retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in the human amniotic environment.

    abstract：INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.05.010

    authors： Prat C,Bouvier D,Comptour A,Marceau G,Belville C,Clairefond G,Blanc P,Gallot D,Blanchon L,Sapin V

    更新日期：2015-08-01 00:00:00

  • Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta.

    abstract：:The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.09.001

    authors： Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani K

    更新日期：2014-11-01 00:00:00

  • Modulation of the novel cannabinoid receptor - GPR55 - during rat fetoplacental development.

    abstract：:Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.03.007

    authors： Fonseca BM,Teixeira NA,Almada M,Taylor AH,Konje JC,Correia-da-Silva G

    更新日期：2011-06-01 00:00:00

  • Review: Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta.

    abstract：:The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of numerous placental functions, including ion and nutrient exchange and the synthesis of steroid and peptide hormones required for fetal growth and development. Inadequate formation and regeneration of this tissue contributes ...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2011.11.007

    authors： Pidoux G,Gerbaud P,Cocquebert M,Segond N,Badet J,Fournier T,Guibourdenche J,Evain-Brion D

    更新日期：2012-02-01 00:00:00

  • Placental pathology in congenital rubella.

    abstract：:Two groups of placentae from 18 cases of maternal rubella were examined morphologically and virologically. Placentae in Group I (four cases) had a mean gestational age of 21 +/- 1.9 weeks, whilst those in Group 2 (14 cases) had a mean gestational age of 38 +/- 2.8 weeks. A tendency to hypoplasia was observed. The micr...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(85)80038-2

    authors： Garcia AG,Marques RL,Lobato YY,Fonseca ME,Wigg MD

    更新日期：1985-07-01 00:00:00

  • Galectin-13/PP-13 expression in term placentas of gestational diabetes mellitus pregnancies.

    abstract：INTRODUCTION:Gestational diabetes mellitus (GDM) is an increasing harm in pregnancy. Inflammatory processes in the placenta seem to have an influence on pathogenesis besides known factors like maternal BMI. Galectin-13 (gal-13) is an immunoregulatory protein, which is suspected to play a role in development of GDM in t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.11.019

    authors： Unverdorben L,Hüttenbrenner R,Knabl J,Jeschke U,Hutter S

    更新日期：2015-02-01 00:00:00

  • Gene expression of nitric oxide synthase in cultured human term placental trophoblast during in vitro differentiation.

    abstract：:The human placental syncytiotrophoblast is derived from differentiating cytotrophoblasts and is in contact with maternal blood. This endothelial function positions the trophoblast to regulate maternal-fetal exchange and to influence circulatory dynamics through paracrine interactions in the placenta. Two isoforms of n...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)90056-x

    authors： Lyall F,Jablonka-Shariff A,Johnson RD,Olson LM,Nelson DM

    更新日期：1998-05-01 00:00:00

  • Alpha-fetoprotein gene expression in early and full-term human trophoblast.

    abstract：:Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0816

    authors： Lafuste P,Robert B,Mondon F,Danan JL,Rossi B,Duc-Goiran P,Mignot TM,Nunez EA,Benassayag C,Ferré F

    更新日期：2002-09-01 00:00:00