当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > The Elsevier Trophoblast Research Award Lecture: Importance of metzincin proteases in trophoblast biology and placental development: a focus on ADAM12.

The Elsevier Trophoblast Research Award Lecture: Importance of metzincin proteases in trophoblast biology and placental development: a focus on ADAM12.

Abstract：

:Placental development is a highly regulated process requiring signals from both fetal and maternal uterine compartments. Within this complex system, trophoblasts, placental cells of epithelial lineage, form the maternal-fetal interface controlling nutrient, gas and waste exchange. The commitment of progenitor villous cytotrophoblasts to differentiate into diverse trophoblast subsets is a fundamental process in placental development. Differentiation of trophoblasts into invasive stromal- and vascular-remodeling subtypes is essential for uterine arterial remodeling and placental function. Inadequate placentation, characterized by defects in trophoblast differentiation, may underlie the earliest cellular events driving pregnancy disorders such as preeclampsia and fetal growth restriction. Molecularly, invasive trophoblasts acquire characteristics defined by profound alterations in cell-cell and cell-matrix adhesion, cytoskeletal reorganization and production of proteolytic factors. To date, most studies have investigated the importance of the matrix metalloproteinases (MMPs) and their ability to efficiently remodel components of the extracellular matrix (ECM). However, it is now becoming clear that besides MMPs, other related proteases regulate trophoblast invasion via mechanisms other than ECM turnover. In this review, we will summarize the current knowledge on the regulation of trophoblast invasion by members of the metzincin family of metalloproteinases. Specifically, we will discuss the emerging roles that A Disintegrin and Metalloproteinases (ADAMs) play in placental development, with a particular focus on the ADAM subtype, ADAM12.

journal_name

Placenta

journal_title

Placenta

authors

Aghababaei M,Beristain AG

doi

10.1016/j.placenta.2014.12.016

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

S11-9

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(14)00916-3

journal_volume

36 Suppl 1

pub_type

杂志文章,评审

相关文献

PLACENTA文献大全
  • mTOR: a placental growth signaling sensor.

    abstract：:The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.02.004

    authors： Wen HY,Abbasi S,Kellems RE,Xia Y

    更新日期：2005-04-01 00:00:00

  • A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta.

    abstract：:Homeobox genes of the Distal-less (Dlx) family are expressed in the vertebrate embryo in regions where epithelial cell layers contact adjacent mesenchymal cells. This study shows that the human Dlx family member, DLX4, is expressed in the placenta, primarily in regions where epithelial and mesenchymal cell layers cont...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)90103-5

    authors： Quinn LM,Latham SE,Kalionis B

    更新日期：1998-01-01 00:00:00

  • Placental expression of D-chiro-inositol phosphoglycans in preeclampsia.

    abstract：:Abnormalities in glucose metabolism linked to D-chiro-inostol phosphoglycans (IPGs) have been described in human placentas of preeclamptic women. In this study, a semi-quantitative approach to assess the histological assessment of IPGs revealed no significant differences between early and late onset preeclampsia and g...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.07.007

    authors： Scioscia M,Siwetz M,Fascilla F,Huppertz B

    更新日期：2012-10-01 00:00:00

  • Cyclic AMP as a second messenger for prorenin release from human decidual cells.

    abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(91)90007-3

    authors： Poisner AM,Thrailkill K,Poisner R,Handwerger S

    更新日期：1991-05-01 00:00:00

  • Receptors for alpha 2-macroglobulin- and pregnancy zone protein-proteinase complexes in the human placental syncytiotrophoblast.

    abstract：:Receptors for complexes between alpha 2-macroglobulin (alpha 2M) and proteinases (e.g. trypsin) were identified and characterized in the human placenta. The receptors also bound the complex formed between pregnancy zone protein (PZP) and chymotrypsin, although with slightly lower affinity, whereas binding of alpha 2M ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(88)90019-7

    authors： Jensen PH,Moestrup SK,Sottrup-Jensen L,Petersen CM,Gliemann J

    更新日期：1988-09-01 00:00:00

  • Placental ultrasonographic biochemical and histochemical studies in human fetuses affected with Niemann-Pick disease type A.

    abstract：:Placental ultrasonographic, bio- and histochemical studies were performed on four unrelated fetuses affected with Niemann-Pick disease Type A, following prostaglandin-induced abortion at about the 19th week of gestation. An accumulation of sphingomyelin in the placentae of affected fetuses indicates the essential role...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(85)80030-8

    authors： Schoenfeld A,Abramovici A,Klibanski C,Ovadia J

    更新日期：1985-01-01 00:00:00

  • ATP independent calcium transport and binding by basal plasma membrane of human placenta.

    abstract：:The transport of large amounts of Ca2+ by the plasma membranes of human placental syncytiotrophoblast is essential to the mineralization of the growing fetal skeleton. We have investigated transport by the basal (fetal-facing) plasma membrane (BPM). Ca2+ was taken up by purified BPM vesicles in a time-dependent manner...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(05)80451-5

    authors： Kamath SG,Haider N,Smith CH

    更新日期：1994-02-01 00:00:00

  • Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells.

    abstract：:Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2003.09.002

    authors： Kikkawa F,Shibata K,Suzuki T,Kajiyama H,Ino K,Nomura S,Mizutani S

    更新日期：2004-02-01 00:00:00

  • Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta.

    abstract：:The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.09.001

    authors： Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani K

    更新日期：2014-11-01 00:00:00

  • Fractional volume of placental vessels in women with diabetes using a novel stereological 3D power Doppler technique.

    abstract：OBJECTIVES:In maternal diabetes the placenta is large with abnormal vascular development and increased villous volume. We used a novel stereological 3D power Doppler ultrasound technique to investigate differences in-vivo in the placental fractional volume of power Doppler signal (FrVol-PD) between women with and witho...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.08.015

    authors： Jones NW,Deshpande R,Mousa HA,Mansell P,Raine-Fenning N,Bugg G

    更新日期：2013-11-01 00:00:00

  • A mathematical model of intervillous blood flow in the human placentone.

    abstract：:We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.11.003

    authors： Chernyavsky IL,Jensen OE,Leach L

    更新日期：2010-01-01 00:00:00

  • Use of Matrigel in culture affects cell phenotype and gene expression in the first trimester trophoblast cell line HTR8/SVneo.

    abstract：:There is inconsistent use of Matrigel for experiments with the HTR8/SVneo first trimester trophoblast and other cell lines. We quantified the effects of Matrigel on the expression of genes considered to be markers of extravillous cytotrophoblast (EVT) differentiation and invasive potential. Culture on Matrigel promote...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.04.003

    authors： Highet AR,Zhang VJ,Heinemann GK,Roberts CT

    更新日期：2012-07-01 00:00:00

  • Permeability of the near-term rat placenta to hydrophilic solutes.

    abstract：:The permeability of the rat placenta at 21 days' gestation (term is 23 days) has been measured with fetuses intact in situ and by perfusion of the fetal circulation. Intact measurements were made by removal of fetuses at known time intervals after injection of radioisotopes to the anaesthetized mother and measurement ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(88)90049-5

    authors： Robinson NR,Atkinson DE,Jones CJ,Sibley CP

    更新日期：1988-07-01 00:00:00

  • Placental diagnostic criteria and clinical correlation--a workshop report.

    abstract：:Placental pathology is a valuable link explaining how underlying pregnancy risk factors result in adverse pregnancy outcome. This potentially useful information is currently underutilized due to a general lack of rigor in placental diagnosis. This lack of rigor is in large part due to a failure to appreciate the impor...

    journal_title：Placenta

    pub_type：

    doi：10.1016/j.placenta.2005.02.009

    authors： Redline RW,Heller D,Keating S,Kingdom J

    更新日期：2005-04-01 00:00:00

  • Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2.

    abstract：:Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits troph...

    journal_title：Placenta

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.placenta.2017.03.008

    authors： Pan Q,Niu H,Cheng L,Li X,Zhang Q,Ning Y

    更新日期：2017-05-01 00:00:00

  • Myofibroblast differentiation in the connective tissues of the amnion and chorion of term human fetal membranes-implications for fetal membrane rupture and labour.

    abstract：:An area of the fetal membranes, within the rupture tear after spontaneous delivery at term, exhibits altered morphology compared to more distal sites. It is characterized by marked swelling of the amniotic and chorionic connective tissue layers, consistent with structural weakness, and a marked reduction of the thickn...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1999.0439

    authors： McParland PC,Taylor DJ,Bell SC

    更新日期：2000-01-01 00:00:00

  • Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor.

    abstract：:Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the pres...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.02.004

    authors： von Versen-Höynck F,Rajakumar A,Bainbridge SA,Gallaher MJ,Roberts JM,Powers RW

    更新日期：2009-05-01 00:00:00

  • Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely correlated with maternal circulating leptin.

    abstract：INTRODUCTION:miRNAs are small non-coding RNAs important for the regulation of mRNA in many organs including placenta. Adipokines and specifically leptin are known to be dysregulated in preeclampsia, but little is known regarding their regulation by miRNAs during pregnancy. METHODS:We performed high-throughput sequenci...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.07.002

    authors： Weedon-Fekjær MS,Sheng Y,Sugulle M,Johnsen GM,Herse F,Redman CW,Lyle R,Dechend R,Staff AC

    更新日期：2014-09-01 00:00:00

  • The Binns Program for Cord Blood Research: A novel model of cord blood banking for academic biomedical research.

    abstract：:Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.10.018

    authors： Mantri S,Sheikali A,Binns C,Lyell DJ,DiGiusto DL,Porteus MH,Agarwal-Hashmi R

    更新日期：2020-10-13 00:00:00

  • Increased matrix metalloproteinases 2 and 9 in placenta of diabetic rats at midgestation.

    abstract：:Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue production of NO, a regulator of MMPs activity. The present work evaluates placental and fetal MMPs and NO levels during midpregnancy in neonatal streptozotocin-induced diabetic ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.06.011

    authors： Pustovrh MC,Jawerbaum A,Capobianco E,White V,López-Costa JJ,González E

    更新日期：2005-04-01 00:00:00

  • Dynamic glucose enhanced MRI of the placenta in a mouse model of intrauterine inflammation.

    abstract：INTRODUCTION:We investigated the feasibility of dynamic glucose enhanced (DGE) MRI in accessing placental function in a mouse model of intrauterine inflammatory injury (IUI). DGE uses the glucose chemical exchange saturation transfer (glucoCEST) effect to reflect infused d-glucose. METHODS:IUI was induced in pregnant ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2018.07.012

    authors： Wu D,Xu J,Lei J,Mclane M,van Zijl PC,Burd I

    更新日期：2018-09-01 00:00:00

  • Lipid deposition and metabolism in rat placenta during gestation.

    abstract：:Changes in placental lipid content in rats at the 15th and 20th days of pregnancy were investigates. It was found that progress of gestation is accompanied by a significant increase in triglycerides per mg placental DNA. Maternal starvation caused additional increase in the placental triglyceride content. By incubatio...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(80)80033-6

    authors： Diamant YZ,Diamant S,Freinkel N

    更新日期：1980-10-01 00:00:00

  • Studies on the localization of 5-hydroxytryptamine and its receptors in human placenta.

    abstract：:The localization of 5-hydroxytryptamine (5-HT) and its receptors in human placenta was studied under light and electron microscopy using immunohistochemistry and in situ hybridization. The syncytiotrophoblast, cytotrophoblast, stromal cells and decidual cells in human placentae all appeared to be 5-HT immunoreactive. ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)90027-3

    authors： Huang WQ,Zhang CL,Di XY,Zhang RQ

    更新日期：1998-11-01 00:00:00

  • All-trans-retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in the human amniotic environment.

    abstract：INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.05.010

    authors： Prat C,Bouvier D,Comptour A,Marceau G,Belville C,Clairefond G,Blanc P,Gallot D,Blanchon L,Sapin V

    更新日期：2015-08-01 00:00:00

  • Immunohistochemical localization of follicle-stimulating hormone, luteinizing hormone, growth hormone, adrenocorticotrophic hormone and prolactin in the human placenta.

    abstract：:The sites of localization of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), adrenocorticotrophic hormone (ACTH) and prolactin (PRL) within placental tissues have been studied by an immunoperoxidase technique. The syncytiotrophoblast is the sole significant site of localization of LH...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(86)80007-8

    authors： Al-Timimi A,Fox H

    更新日期：1986-03-01 00:00:00

  • Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.

    abstract：:To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after stimulation with various modulatory agents of cytokine ex...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1999.0494

    authors： Fujisawa K,Nasu K,Arima K,Sugano T,Narahara H,Miyakawa I

    更新日期：2000-05-01 00:00:00

  • Telomere homeostasis in IUGR placentas - A review.

    abstract：:Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2015.11.006

    authors： Biron-Shental T,Sadeh-Mestechkin D,Amiel A

    更新日期：2016-03-01 00:00:00

  • Impact of placental growth factor deficiency on early mouse implant site angiogenesis.

    abstract：:Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or mate...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.07.006

    authors： Rätsep MT,Carmeliet P,Adams MA,Croy BA

    更新日期：2014-09-01 00:00:00

  • Identification of 72-kilodalton type IV collagenase at sites of trophoblastic invasion of macaque spiral arteries.

    abstract：:The walls of uterine spiral arteries are invaded by extravillous trophoblast cells and are thereby converted to the uteroplacental arteries of pregnancy. The mechanisms by which this invasion occurs are not understood, but the extracellular matrices that are breached suggest participation by specific proteinases. In t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(05)80454-0

    authors： Blankenship TN,King BF

    更新日期：1994-02-01 00:00:00

  • In vitro fertilization is associated with the onset and progression of preeclampsia.

    abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.09.011

    authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

    更新日期：2020-01-01 00:00:00