Increased matrix metalloproteinases 2 and 9 in placenta of diabetic rats at midgestation.

abstract：:Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...

journal_title：Placenta

authors： Many A,Westerhausen-Larson A,Kanbour-Shakir A,Roberts JM

更新日期：1996-07-01 00:00:00

abstract：:Autophagy, a process for cellular cleaning through the removal of intracellular components in lysosomes, is a well conserved mechanism from yeast to mammalian cells, and also contributes to the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodeling, and cellular defense aga...

journal_title：Placenta

authors： Saito S,Nakashima A

更新日期：2013-03-01 00:00:00

abstract：:The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...

journal_title：Placenta

authors： Wang Y,Pringle KG,Lumbers ER

更新日期：2013-03-01 00:00:00

abstract：:Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Now, more than half a century later, it is well understood that with the initiation of pregnancy, immune cel...

journal_title：Placenta

authors： Hunt JS,Petroff MG

更新日期：2013-03-01 00:00:00

abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

journal_title：Placenta

authors： Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...

journal_title：Placenta

authors： Xu T,Zhou Z,Liu N,Deng C,Huang G,Zhou F,Liu X,Wang X

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by an intervillous mononuclear inflammatory infiltrate of maternal origin. Although the mechanism and origin of these lesions are currently not understood, they appear to be related to an immune conflict...

journal_title：Placenta

authors： Capuani C,Meggetto F,Duga I,Danjoux M,March M,Parant O,Brousset P,Aziza J

更新日期：2013-02-01 00:00:00

abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

journal_title：Placenta

authors： Loke YW,King A

更新日期：1990-07-01 00:00:00

abstract：INTRODUCTION:Chronic abruption oligohydramnios sequence (CAOS) is histologically characterized by diffuse chorioamniotic hemosiderosis (DCH). However, the criteria for the histological evaluation of the extent of CAOS-related hemosiderin deposition (HD) of the membranes and the difference in HD between the chorionic pl...

journal_title：Placenta

authors： Ishida A,Minamiguchi S,Yamada Y,Nakagawa R,Chigusa Y,Kondoh E,Mandai M,Haga H

更新日期：2021-01-20 00:00:00

abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...

journal_title：Placenta

authors： Braun T,Husar A,Challis JR,Dudenhausen JW,Henrich W,Plagemann A,Sloboda DM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...

journal_title：Placenta

authors： Moon KC,Park JS,Norwitz ER,Kim DI,Oh KJ,Park CW,Jun JK,Syn HC

更新日期：2008-05-01 00:00:00

abstract：:Uterine blood flow (UtBF) is a major regulator of transplacental fetal nutrient supply. The aim was to serially measure uterine blood flow from mid to late pregnancy in a paradigm of relatively late onset placental and fetal growth restriction. Singleton bearing adolescent dams was fed high (H) or control (C) nutrient...

journal_title：Placenta

authors： Wallace JM,Milne JS,Matsuzaki M,Aitken RP

更新日期：2008-08-01 00:00:00

abstract：:The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclamp...

journal_title：Placenta

authors： Rani A,Chavan-Gautam P,Mehendale S,Wagh G,Mani NS,Joshi S

更新日期：2020-06-01 00:00:00

abstract：:Placentas and plasma from women with and without Chagas' disease and cultures of human placental villi with Trypanosoma cruzi, neuraminidase, phospholipase A2 and phospholipase C were analyzed in order to verify if the alterations in placental alkaline phosphatase (PLAP) enzyme activity are caused by T. cruzi as obser...

journal_title：Placenta

authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

更新日期：2005-11-01 00:00:00

abstract：:The aim of this work was to characterize the uptake of 1-methyl-4-phenylpyridinium (MPP(+)) in the JAR human choriocarcinoma cell line. As JAR cells, as well as the placenta, express the neuronal serotonin transporter (SERT), a comparison between the uptake of (3)H-MPP(+) and (3)H-serotonin ((3)H-5HT) was made. Specif...

journal_title：Placenta

authors： Martel F,Keating E

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Dietrich Starck (1908-2001) was a German embryologist who wrote extensive reviews on comparative placentation. FINDINGS:Starck's embryology textbook and his comprehensive review of comparative embryology and placentation give excellent insights into the foundational literature and are extensively referenced...

journal_title：Placenta

authors： Carter AM

更新日期：2017-10-01 00:00:00

abstract：:Pregnancy induces a number of alterations to maternal physiology to accommodate the increased demands made by the developing fetus and placenta. These alterations appear at least in part to be driven by products derived from the feto-placental unit, including microchimeric cells, as well as placental exosomes and micr...

journal_title：Placenta

authors： Clifton VL,Stark MJ,Osei-Kumah A,Hodyl NA

更新日期：2012-02-01 00:00:00

abstract：:The ovaries and uteri were removed from four pregnant camels on days 14, 25, 35 and 56 after ovulation. The day 14 and 25 uteri were perfuse-fixed with 3 per cent glutaraldehyde: 3 per cent paraformaldehyde whereas the day 35 and 56 specimens were opened dorsally for photography before biopsies of allantochorion attac...

journal_title：Placenta

authors： Skidmore JA,Wooding FB,Allen WR

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...

journal_title：Placenta

authors： Nakada E,Walley KR,Nakada T,Hu Y,von Dadelszen P,Boyd JH

更新日期：2009-09-01 00:00:00

abstract：:The human placenta contains two types of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). The exclusive oxidase 11beta-HSD2 has been suggested to protect the fetus from high levels of maternal glucocorticoids by converting cortisol to inactive cortisone. Perfused term human placenta was used to examine the activity o...

journal_title：Placenta

authors： Sun K,Adamson SL,Yang K,Challis JR

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:A major issue in the transcriptomic study of spontaneous preterm birth (sPTB) in humans is the inability to collect healthy control tissue at the same gestational age (GA) to compare with pathologic preterm tissue. Thus, gene expression differences identified after the standard comparison of sPTB and term ...

journal_title：Placenta

authors： Eidem HR,Rinker DC,Ackerman WE 4th,Buhimschi IA,Buhimschi CS,Dunn-Fletcher C,Kallapur SG,Pavličev M,Muglia LJ,Abbot P,Rokas A

更新日期：2016-05-01 00:00:00

abstract：:The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...

journal_title：Placenta

authors： Conrad KP,Davis AK

更新日期：1995-12-01 00:00:00

abstract：:The aim of this study was to investigate localization and content of activin beta A-subunit and activin receptors in gestational tissues throughout pregnancy and in association with term labour. Placenta and fetal membranes were collected from women undergoing first and second trimester terminations and from women bef...

journal_title：Placenta

authors： Schneider-Kolsky ME,Manuelpillai U,Waldron K,Dole A,Wallace EM

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...

journal_title：Placenta

authors： Bose P,Kadyrov M,Goldin R,Hahn S,Backos M,Regan L,Huppertz B

更新日期：2006-08-01 00:00:00

abstract：:Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...

journal_title：Placenta

authors： Biron-Shental T,Sadeh-Mestechkin D,Amiel A

更新日期：2016-03-01 00:00:00

abstract：:Paracellular pathways in the haemotrichorial placenta of the rat were studied by electron microscopy using lanthanum hydroxide as an electron dense marker. Near term placentae were dually perfused in situ, adding lanthanum to the fetal perfusate. In some placentae outflow pressure on the fetal side was elevated (betwe...

journal_title：Placenta

authors： Kertschanska S,Stulcová B,Kaufmann P,Stulc J

更新日期：2000-09-01 00:00:00

abstract：:The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...

journal_title：Placenta

authors： Kwek K,Read MA,Khong TY,Bisits AT,Walters WA

更新日期：2001-07-01 00:00:00

abstract：:Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...

journal_title：Placenta

authors： Gratton RJ,Gluszynski M,Nygard K,Mazzuca DM,Graham CH,Han VK

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Epigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of ca...

journal_title：Placenta

authors： Janssen BG,Byun HM,Cox B,Gyselaers W,Izzi B,Baccarelli AA,Nawrot TS

更新日期：2014-09-01 00:00:00

abstract：:Apart from during the prepartal period, the main oestrogen produced by the bovine trophoblast is oestrone sulphate (E1S) which does not bind to nuclear oestrogen receptors (ER). High steroid sulphatase (StS) activities previously detected in the maternal part of bovine placentomes (caruncles) suggest the local activat...

journal_title：Placenta

authors： Greven H,Kowalewski MP,Hoffmann B,Geyer J,Rex-Haffner M,Ugele B,Schuler G

更新日期：2007-08-01 00:00:00