Abstract:
:Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or maternal PGF deficiency. Implant site number and embryonic development were similar in Pgf(-/-) and Pgf(+/+) females although Pgf(-/-) lymphatic vessels were anomalous. Correct, fine branching angiogenesis of anti-mesometrial vessels required both conceptus and maternal PGF; correct mesometrial branching angiogenesis depended solely upon conceptus PGF. Thus, PGF is non-redundant for optimizing branching angiogenesis in early decidua.
journal_name
Placentajournal_title
Placentaauthors
Rätsep MT,Carmeliet P,Adams MA,Croy BAdoi
10.1016/j.placenta.2014.07.006subject
Has Abstractpub_date
2014-09-01 00:00:00pages
772-5issue
9eissn
0143-4004issn
1532-3102pii
S0143-4004(14)00607-9journal_volume
35pub_type
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