A mathematical model of intervillous blood flow in the human placentone.

abstract：:The recent demonstration of multiple high-affinity leucine-sensitive cationic transport systems prompted this investigation of their role in lysine uptake in basal cell membrane. Transport of lysine by basal membrane was saturable at both 22 and 37 degrees C and linear in time to 1 min and 30 sec, respectively. At 22 ...

journal_title：Placenta

authors： Furesz TC,Smith CH

更新日期：1997-11-01 00:00:00

abstract：:Dynamics of genome multiplication during establishment of interrelations between trophoblast and glandular epithelium of the endometrium has been studied in the course of formation of placenta in the silver fox. During formation of the placenta, penetration of the trophoblast into the zone of the endometrial glandular...

journal_title：Placenta

authors： Zybina TG,Zybina EV,Kiknadze II,Zhelezova AI

更新日期：2001-05-01 00:00:00

abstract：:This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...

journal_title：Placenta

authors： Santos TC,Dantzer V,Jones CJ,Oliveira MF,Miglino MA

更新日期：2006-02-01 00:00:00

abstract：:Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca(2+)-dependent manner. Annexin-A5 (AnxA5), the smallest member of the annexin family, presents unique properties of membrane binding and self-assembly into ordered two-dim...

journal_title：Placenta

authors： Bouter A,Carmeille R,Gounou C,Bouvet F,Degrelle SA,Evain-Brion D,Brisson AR

更新日期：2015-04-01 00:00:00

abstract：:The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...

journal_title：Placenta

authors： Conrad KP,Davis AK

更新日期：1995-12-01 00:00:00

abstract：:The aim of this study was to investigate localization and content of activin beta A-subunit and activin receptors in gestational tissues throughout pregnancy and in association with term labour. Placenta and fetal membranes were collected from women undergoing first and second trimester terminations and from women bef...

journal_title：Placenta

authors： Schneider-Kolsky ME,Manuelpillai U,Waldron K,Dole A,Wallace EM

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...

journal_title：Placenta

authors： Ernst LM,Minturn L,Huang MH,Curry E,Su EJ

更新日期：2013-07-01 00:00:00

abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...

journal_title：Placenta

authors： Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado M

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Perfluorinated alkyl acids (PFAAs) are widely used in industry and consumer products. Pregnant women are exposed to PFAAs and their presence in umbilical cord blood represents fetal exposure. Interestingly, PFAAs are substrates for organic anion transporters (OAT) of which OAT4 is expressed in human placen...

journal_title：Placenta

authors： Kummu M,Sieppi E,Koponen J,Laatio L,Vähäkangas K,Kiviranta H,Rautio A,Myllynen P

更新日期：2015-10-01 00:00:00

abstract：:Nitrotyrosine residues (NT), an index of oxidative stress arising from peroxynitrite formation and action, are found in placental vasculature of pregnancies complicated by pre-eclampsia (PE) or pregestational insulin-dependent diabetes mellitus (IDDM). This study correlates conventional placental pathology with NT imm...

journal_title：Placenta

authors： Stanek J,Eis AL,Myatt L

更新日期：2001-04-01 00:00:00

abstract：INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...

journal_title：Placenta

authors： Xu T,Zhou Z,Liu N,Deng C,Huang G,Zhou F,Liu X,Wang X

更新日期：2019-08-01 00:00:00

abstract：:The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...

journal_title：Placenta

authors： Racca AC,Ridano ME,Bandeira CL,Bevilacqua E,Avvad Portari E,Genti-Raimondi S,Graham CH,Panzetta-Dutari GM

更新日期：2016-09-01 00:00:00

abstract：:A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...

journal_title：Placenta

authors： Muñoz M,Pavón A,Rosso M,Salinas MV,Pérez A,Carranza A,González-Ortega A

更新日期：2010-07-01 00:00:00

abstract：:The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclamp...

journal_title：Placenta

authors： Rani A,Chavan-Gautam P,Mehendale S,Wagh G,Mani NS,Joshi S

更新日期：2020-06-01 00:00:00

abstract：:Eighty-one placentae from women with leprosy and 17 placentae from healthy controls were subjected to a detailed macroscopic, light microscopic, ultrastructural, immunopathological, microbiological and biochemical study. The placental morphology and immunohistology were normal, and there was no morphological evidence ...

journal_title：Placenta

authors： Duncan ME,Fox H,Harkness RA,Rees RJ

更新日期：1984-05-01 00:00:00

abstract：:The walls of uterine spiral arteries are invaded by extravillous trophoblast cells and are thereby converted to the uteroplacental arteries of pregnancy. The mechanisms by which this invasion occurs are not understood, but the extracellular matrices that are breached suggest participation by specific proteinases. In t...

journal_title：Placenta

authors： Blankenship TN,King BF

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Maternal magnesium (Mg) deficiency has been associated with fetal growth restriction. Using a mouse model of maternal Mg deficiency-induced fetal growth restriction, we sought to investigate the effect of Mg deficiency on placental physiology and function. METHODS:In vivo: Pregnant Swiss Webster mice were fe...

journal_title：Placenta

authors： Rosner JY,Gupta M,McGill M,Xue X,Chatterjee PK,Yoshida-Hay M,Robeson W,Metz CN

更新日期：2016-03-01 00:00:00

abstract：:We present a case of intra-amniotic umbilical vein varix with thrombosis using conventional two-dimensional (2D) sonography, power Doppler, three-dimensional (3D) HD-flow, and HDlive at 35 weeks of gestation. 2D sonography showed a large banana-like umbilical cord enlargement (100 × 43.3 × 45.9 mm) including umbilical...

journal_title：Placenta

authors： Kanenishi K,Nitta E,Mashima M,Hanaoka U,Koyano K,Tanaka H,Hata T

更新日期：2013-11-01 00:00:00

abstract：:Placenta accreta is a pregnancy complication characterized by the presence of life-threatening uteroplacental neovascularization. The factors involving its development are unknown. Vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors (VEGFR) have important roles in vascular remo...

journal_title：Placenta

authors： Tseng JJ,Chou MM,Hsieh YT,Wen MC,Ho ES,Hsu SL

更新日期：2006-01-01 00:00:00

abstract：:Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease. It is based on the concept that application of gene therapy vectors to the fetus in utero may prevent the development of early disease related tissue damage, may allow targeting of otherwise inaccessible organs, tissues and still e...

journal_title：Placenta

authors： Coutelle C,Themis M,Waddington S,Gregory L,Nivsarkar M,Buckley S,Cook T,Rodeck C,Peebles D,David A

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways. METHODS:Rats were fed a normal o...

journal_title：Placenta

authors： Lin YJ,Huang LT,Tsai CC,Sheen JM,Tiao MM,Yu HR,Lin IC,Tain YL

更新日期：2019-03-01 00:00:00

abstract：:Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...

journal_title：Placenta

authors： Pongcharoen S,Somran J,Sritippayawan S,Niumsup P,Chanchan P,Butkhamchot P,Tatiwat P,Kunngurn S,Searle RF

更新日期：2007-01-01 00:00:00

abstract：:The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...

journal_title：Placenta

authors： Danzeisen R,Ponnambalam S,Lea RG,Page K,Gambling L,McArdle HJ

更新日期：2000-11-01 00:00:00

abstract：:During pregnancy, changes in oxygen tension are essential for proper embryonic and placental development. Little is known about the mechanisms underlying mammalian cellular adaptations to changes in oxygen tension. Currently, we have explored putative mechanisms by which human trophoblast cells may sense oxygen. In or...

journal_title：Placenta

authors： De Marco CS,Caniggia I

更新日期：2002-04-01 00:00:00

abstract：:Bovine nuclear transfer pregnancies are characterized by a high incidence of placental abnormalities, notably, increased placentome size and deficiencies in trophoblast cell function and establishment of placental vasculature. Alterations in gene expression during placental growth and development may contribute to the...

journal_title：Placenta

authors： Ravelich SR,Shelling AN,Wells DN,Peterson AJ,Lee RS,Ramachandran A,Keelan JA

更新日期：2006-02-01 00:00:00

abstract：:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...

journal_title：Placenta

authors： Dilworth MR,Kusinski LC,Baker BC,Renshall LJ,Baker PN,Greenwood SL,Wareing M,Sibley CP

更新日期：2012-12-01 00:00:00

abstract：:Despite the vital and diverse roles of the placenta, remarkably little is known about its actual composition. Moreover, as placentophagy becomes increasingly popular, understanding the nutritional and heavy metal composition of the human placenta has practical implications. Here we evaluated the carbohydrate, sugar, p...

journal_title：Placenta

authors： Chang S,Lodico L,Williams Z

更新日期：2017-12-01 00:00:00

abstract：:Pregnancy-specific beta 1-glycoprotein (Schwangerschaftsprotein, SP1) is elevated in the amniotic fluid in Meckel's syndrome. In an attempt to clarify this phenomenon, we studied fetal tissues by immunohistochemistry for the distribution of SP1 in normal fetuses and fetuses with Meckel's syndrome. The amount of SP1 wa...

journal_title：Placenta

authors： Heikinheimo M,Jalanko H,Renlund M,Rapola J,Wahlström T

更新日期：1987-07-01 00:00:00

abstract：:Endotheliochorial placentas occur in orders from all four major clades of eutherian mammal. Species with this type of placenta include one of the smallest (pygmy shrew) and largest (African elephant) land mammals. The endotheliochorial placenta as a definitive form has an interhemal area consisting of maternal endothe...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Pregestational maternal obesity (PGMO) associates with foetoplacental vascular endothelial dysfunction and higher risk for insulin resistance in the neonate. We characterised the PGMO consequences on the insulin response of the human foetoplacental vasculature. METHODS:Umbilical veins were from pregnancies w...

journal_title：Placenta

authors： Villalobos-Labra R,Westermeier F,Pizarro C,Sáez PJ,Toledo F,Pardo F,Kusanovic JP,Mardones F,Poblete JA,Sobrevia L,Farías M

更新日期：2019-10-01 00:00:00