Studies on the elevated amniotic fluid SP1 in Meckel's syndrome: modified glycosylation of SP1.

abstract：:Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

journal_title：Placenta

authors： Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

更新日期：1989-03-01 00:00:00

abstract：:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....

journal_title：Placenta

authors： Umezawa A,Hasegawa A,Inoue M,Tanuma-Takahashi A,Kajiwara K,Makino H,Chikazawa E,Okamoto A

更新日期：2019-09-01 00:00:00

abstract：:Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The meta...

journal_title：Placenta

authors： Delhaes F,Giza SA,Koreman T,Eastabrook G,McKenzie CA,Bedell S,Regnault TRH,de Vrijer B

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...

journal_title：Placenta

authors： Bose P,Kadyrov M,Goldin R,Hahn S,Backos M,Regan L,Huppertz B

更新日期：2006-08-01 00:00:00

abstract：:The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...

journal_title：Placenta

authors： Hou YP,Gu JY,Shao YF,Song YF,Jing YH,Wu WS,Pu S

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...

journal_title：Placenta

authors： Allsopp R,Shimoda J,Easa D,Ward K

更新日期：2007-04-01 00:00:00

abstract：:The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclamp...

journal_title：Placenta

authors： Rani A,Chavan-Gautam P,Mehendale S,Wagh G,Mani NS,Joshi S

更新日期：2020-06-01 00:00:00

abstract：:Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...

journal_title：Placenta

authors： Winship A,Cuman C,Rainczuk K,Dimitriadis E

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...

journal_title：Placenta

authors： Koppes E,Shaffer B,Sadovsky E,Himes K,Barak Y,Sadovsky Y,Chaillet JR

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Histologic placental and/or intra-amniotic inflammation is frequently documented during ascending intra-uterine infections in patients with preterm labor and intact membranes. Placenta previa can be a clinical situation that shows the successive schema of histologic placental and intra-amniotic inflammation d...

journal_title：Placenta

authors： Park CW,Moon KC,Park JS,Jun JK,Yoon BH

更新日期：2009-07-01 00:00:00

abstract：:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...

journal_title：Placenta

authors： Cooper EJ,Wareing M,Greenwood SL,Baker PN

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...

journal_title：Placenta

authors： Tsur A,Kalish F,Burgess J,Nayak NR,Zhao H,Casey KM,Druzin ML,Wong RJ,Stevenson DK

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that pregnancies complicated by placentas with an isolated single umbilical artery (iSUA) are at increased risk for small-for-gestational-age (SGA) births. The etiology of SGA in this population, however, remains unknown. OBJECTIVE:The primary objective of this study was to evalu...

journal_title：Placenta

authors： Battarbee AN,Palatnik A,Ernst LM,Grobman WA

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Women with adverse pregnancy outcomes (APOs) have excess risk of later life cardiovascular disease (CVD) perhaps related to an underlying high-risk vascular phenotype. We sought to determine if placental evidence of maternal malperfusion in uncomplicated pregnancies is associated with an increased risk of ...

journal_title：Placenta

authors： Hauspurg A,Redman EK,Assibey-Mensah V,Tony Parks W,Jeyabalan A,Roberts JM,Catov JM

更新日期：2018-12-15 00:00:00

abstract：:The transport of large amounts of Ca2+ by the plasma membranes of human placental syncytiotrophoblast is essential to the mineralization of the growing fetal skeleton. We have investigated transport by the basal (fetal-facing) plasma membrane (BPM). Ca2+ was taken up by purified BPM vesicles in a time-dependent manner...

journal_title：Placenta

authors： Kamath SG,Haider N,Smith CH

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:We investigated the feasibility of dynamic glucose enhanced (DGE) MRI in accessing placental function in a mouse model of intrauterine inflammatory injury (IUI). DGE uses the glucose chemical exchange saturation transfer (glucoCEST) effect to reflect infused d-glucose. METHODS:IUI was induced in pregnant ...

journal_title：Placenta

authors： Wu D,Xu J,Lei J,Mclane M,van Zijl PC,Burd I

更新日期：2018-09-01 00:00:00

abstract：:During early pregnancy, intermediate (extravillous) trophoblast infiltrates the basal plate and invades the spiral arteries, a physiological process required to establish the maternal-fetal circulation. Immunostaining studies have shown that differentiation of trophoblast into this invasive subpopulation is associated...

journal_title：Placenta

authors： Shih IeM,Hsu MY,Oldt RJ 3rd,Herlyn M,Gearhart JD,Kurman RJ

更新日期：2002-11-01 00:00:00

abstract：:Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...

journal_title：Placenta

authors： Zhao S,Gu Y,Dong Q,Fan R,Wang Y

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...

journal_title：Placenta

authors： Matsubara S,Yamada T,Minakami H,Watanabe T,Takizawa T,Sato I

更新日期：1999-03-01 00:00:00

abstract：:Forkhead box O (FoxO) proteins regulate inflammation, extracellular matrix (ECM) remodelling and apoptosis. We have previously identified FoxO1 proteins in human gestational tissues, and demonstrated a link between FoxO1 and rupture of fetal membranes. There is, however, no data available on the expression and localis...

journal_title：Placenta

authors： Lappas M,Lim R,Riley C,Menon R,Permezel M

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:The breast cancer resistance protein (BCRP/ABCG2) is an efflux transporter in the placental barrier. By transporting chemicals from the fetal to the maternal circulation, BCRP limits fetal exposure to a range of drugs, toxicants, and endobiotics such as bile acids and hormones. The purpose of the present s...

journal_title：Placenta

authors： Szilagyi JT,Vetrano AM,Laskin JD,Aleksunes LM

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:In maternal diabetes the placenta is large with abnormal vascular development and increased villous volume. We used a novel stereological 3D power Doppler ultrasound technique to investigate differences in-vivo in the placental fractional volume of power Doppler signal (FrVol-PD) between women with and witho...

journal_title：Placenta

authors： Jones NW,Deshpande R,Mousa HA,Mansell P,Raine-Fenning N,Bugg G

更新日期：2013-11-01 00:00:00

abstract：:Hyperplastic placentas have been reported in several experimental mouse models, including animals produced by somatic cell nuclear transfer, by inter(sub)species hybridization, and by somatic cytoplasm introduction to oocytes followed by intracytoplasmic sperm injection. Of great interest are the gross and histologica...

journal_title：Placenta

authors： Wakisaka N,Inoue K,Ogonuki N,Miki H,Sekita Y,Hanaki K,Akatsuka A,Kaneko-Ishino T,Ishino F,Ogura A

更新日期：2008-08-01 00:00:00

abstract：:Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...

journal_title：Placenta

authors： Fonseca BM,Teixeira NA,Almada M,Taylor AH,Konje JC,Correia-da-Silva G

更新日期：2011-06-01 00:00:00

abstract：:Apoptosis is thought to participate pathophysiologically in the rupture of human fetal membranes (ROM). The aim of this study was to assess apoptosis of the amnion and the chorion in relation to ROM and chorioamnionitis (CAM). The amnion and chorion at the position of the cervical os and fundus of the uterus were obta...

journal_title：Placenta

authors： Kataoka S,Furuta I,Yamada H,Kato EH,Ebina Y,Kishida T,Kobayashi N,Fujimoto S

更新日期：2002-02-01 00:00:00

abstract：:Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence d...

journal_title：Placenta

authors： Riley SC,Challis JR

更新日期：1991-03-01 00:00:00

abstract：INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...

journal_title：Placenta

authors： Prat C,Bouvier D,Comptour A,Marceau G,Belville C,Clairefond G,Blanc P,Gallot D,Blanchon L,Sapin V

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Soluble fms-like tyrosine kinase 1 (sFLT-1) is an anti-angiogenic factor implicated in the pathogenesis of preterm preeclampsia. We evaluated sFLT-1 expression and placental pathology in pregnancies complicated by small for gestational age (SGA) infants (<10th percentile), without evidence of preeclampsia....

journal_title：Placenta

authors： Spiel M,Salahuddin S,Pernicone E,Zsengeller Z,Wang A,Modest AM,Karumanchi SA,Hecht JL

更新日期：2017-04-01 00:00:00

abstract：:TRH immunological and biological activity was characterized in rat placental extracts. Placentae were extracted sequentially with 2 N acetic acid and glacial acetic acid. The lyophilized residues were further extracted with 90 per cent methanol, and the extracts were then dried, and reextracted with distilled water. W...

journal_title：Placenta

authors： Shambaugh GE 3rd,Kubek M,Wilber JF

更新日期：1983-10-01 00:00:00

abstract：:The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...

journal_title：Placenta

authors： Schneider H

更新日期：2000-03-01 00:00:00