Abstract:
:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine. Endothelial cells are obtained from large arteries and veins in the amniotic membrane as well as the umbilical cord. The amnion-derived cells exhibit transdifferentiation capabilities, including chondrogenesis and cardiomyogenesis, by introduction of transcription factors, in addition to their original and potential phenotypes. The amnion is also a source for production of induced pluripotent stem cells (AM-iPSCs). The AM-iPSCs exhibit stable phenotypes, such as multipotency and immortality, and a unique gene expression pattern. Through the use of amnion-derived cells, as well as other placenta-derived cells, preclinical proof of concept has been achieved in a mouse model of muscular dystrophy.
journal_name
Placentajournal_title
Placentaauthors
Umezawa A,Hasegawa A,Inoue M,Tanuma-Takahashi A,Kajiwara K,Makino H,Chikazawa E,Okamoto Adoi
10.1016/j.placenta.2019.06.381subject
Has Abstractpub_date
2019-09-01 00:00:00pages
50-56eissn
0143-4004issn
1532-3102pii
S0143-4004(19)30027-Xjournal_volume
84pub_type
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