Abstract：
:TRH immunological and biological activity was characterized in rat placental extracts. Placentae were extracted sequentially with 2 N acetic acid and glacial acetic acid. The lyophilized residues were further extracted with 90 per cent methanol, and the extracts were then dried, and reextracted with distilled water. When a 100 000 g supernatant fraction of this extract was utilized for characterization, TRH extracted from the placenta was found to be similar to synthetic TRH by four criteria: parallelism of immunoassay inhibition curves, similarity of elution volumes after Sephadex G-10 chromatography, TRH biological activity (TSH release from rat pituitaries in vitro), and identity on high-pressure liquid chromatography. Between the 16th and 20th day of gestation, placental TRH activity increased nearly threefold, from 10.9 +/- 3.0 to 29.7 +/- 3.7 pg/mg protein. Changes of a similar magnitude were apparent in the fetal brain (6.0 +/- 0.5 to 18.9 +/- 2.4 pg/mg protein). Our studies suggest that TRH activity in the rat placenta increases with gestational age in a pattern similar to that described previously for certain placental protein hormones and developmental changes in fetal brain TRH.
journal_name
Placentajournal_title
Placentaauthors
Shambaugh GE 3rd,Kubek M,Wilber JFdoi
10.1016/s0143-4004(83)80036-8subject
Has Abstractpub_date
1983-10-01 00:00:00pages
329-37issue
4eissn
0143-4004issn
1532-3102pii
S0143-4004(83)80036-8journal_volume
4pub_type
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