Abstract:
:Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrophoblasts. We aimed to determine the expression and immunolocalization of FBLN5 in human first trimester decidua and examine the effect of FBLN5 in trophoblast invasion in vitro using a first trimester placental villous outgrowth assay. We demonstrated that FBLN5 mRNA expression is upregulated in response to cAMP-mediated decidualization of primary human endometrial stromal cells, although FBLN5 itself does not enhance decidualization. We reported for the first time, FBLN5 protein production in first trimester decidual cells and also co-localization to HLAG-positive EVTs in first trimester decidua. Consequently, we investigated the effects of exogenous FBLN5 on placental villous outgrowth in vitro and demonstrated that FBLN5 promotes EVT migration/invasion. This is the first study to identify FBLN5 in decidualized human endometrial stromal cells, first trimester decidua and EVT and determine a functional role for FBLN5 in human EVTs, suggesting that decidual and or EVT-derived FBLN5 regulates EVT invasion and placentation in women.
journal_name
Placentajournal_title
Placentaauthors
Winship A,Cuman C,Rainczuk K,Dimitriadis Edoi
10.1016/j.placenta.2015.10.008subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1405-11issue
12eissn
0143-4004issn
1532-3102pii
S0143-4004(15)30068-0journal_volume
36pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Placental vascular tone is critically influenced by nitric oxide (NO) derived from endothelial NO synthase (eNOS) activity. Placental vessels from pregnancies complicated with intrauterine growth restriction present altered NOS-dependent vasodilation. Arginase-2 competes with eNOS for l-arginine and counteracts the NO...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.09.015
更新日期:2013-01-01 00:00:00
abstract::The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.04.003
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their behavior may partly unde...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.05.009
更新日期:2012-09-01 00:00:00
abstract::The interaction of cocaine and its analog 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane (RTI-55) with the human placental serotonin transporter was investigated. The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush bord...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(94)90018-3
更新日期:1994-04-01 00:00:00
abstract::Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining wit...
journal_title:Placenta
pub_type: 杂志文章,多中心研究
doi:10.1016/j.placenta.2013.09.004
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Scant data on placental lymphatic vessels have pointed to the absence of lymphatic circulation. A recent study on mesenchymal dysplasia (MD), however, has identified pathologic lymphangiogenesis using the D2-40 lymphatic marker. These conflicting data have prompted us to investigate whether lymphatic vessels...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.01.013
更新日期:2011-04-01 00:00:00
abstract::The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90066-2
更新日期:1998-05-01 00:00:00
abstract:INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder unique to pregnancy that is associated with increased rates of fetal distress and demise. While acute hypoxia is believed to cause the pathophysiology of ICP, direct molecular evidence for this is lacking. Here, we analyzed expression of three...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.06.372
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Infection accounts for over 40% of preterm premature rupture of the fetal membranes (PPROM), a major cause of preterm birth. Toll-like receptors (TLR) play key roles in pathogen surveillance but their expression and function in amnion mesenchymal cells (AMC) is unclear. The aims of this study were to deter...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.06.005
更新日期:2016-08-01 00:00:00
abstract::Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.021
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.09.007
更新日期:2006-08-01 00:00:00
abstract::We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0610
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:Transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta. METHODS:Transfer of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.07.001
更新日期:2013-10-01 00:00:00
abstract::Early placental development is characterised by rapid cell differentiation and migration, matrix remodelling and angiogenesis. The enzyme NAD(P)H oxidase is a major source of superoxide anions implicated in signalling pathways regulating these processes in other systems. It is also thought to be involved in oxygen sen...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.02.013
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION:Feeding pregnant broodmares with cereal concentrates has been shown to increase maternal insulin resistance and affect foal metabolism in the short and long-term. These effects are likely to be mediated by the placenta. Here, we investigated feto-placental biometry and placental structure and function at t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.02.003
更新日期:2018-04-01 00:00:00
abstract::Glutamine is the most versatile amino acid and its plasma concentration is the highest of all amino acid. Many transporters are therefore involved in glutamine uptake or efflux. Glutamine is actively released from the placenta into fetal circulation. In this study, we examined the alteration of transporters that trans...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.09.009
更新日期:2009-12-01 00:00:00
abstract:INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.02.005
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:To compare the intertwin umbilical cord coiling in twin-twin transfusion syndrome (TTTS) before fetoscopic laser treatment and to correlate these with Doppler findings in both twins. METHODS:We performed a prospective study using three-dimensional (3D) ultrasound with color Doppler imaging of the umbilica...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.01.013
更新日期:2019-01-15 00:00:00
abstract::This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.02.017
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To evaluate pregnancy outcome and ultrasound diagnosis in patients with histologically-confirmed placental chorioangioma. STUDY DESIGN:Placentas with histological diagnosis of chorioangioma were identified and medical charts were reviewed for findings of ultrasound examinations. Pregnancy outcomes were compa...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.06.007
更新日期:2011-09-01 00:00:00
abstract::Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.04.003
更新日期:2010-07-01 00:00:00
abstract::Physiological data indicate that both a transcellular and a paracellular pathway are available for transfer across the human placenta but the morphological correlate of the latter is uncertain. We measured the permeability of the dually perfused human placental cotyledon to the predominantly cationic protein horseradi...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80249-8
更新日期:1993-01-01 00:00:00
abstract::Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.01.017
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestatio...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.06.016
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-asso...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.06.012
更新日期:2009-10-01 00:00:00
abstract::The present study was designed to quantify the major cellular metabolites in human placentae and their changes due to the confounding effect of time and subsequent hypoxia during sample collection using magnetic resonance spectroscopy ((1)H-and (31)P-MRS). The absolute placental concentrations of lactate, glucose, maj...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0908
更新日期:2003-02-01 00:00:00
abstract::Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imagin...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2020.01.016
更新日期:2020-12-01 00:00:00
abstract::Prior studies have shown that levels of corticotrophin-releasing hormone (CRH) in the umbilical cord blood of infants born after pregnancies complicated by pre-eclampsia are significantly higher than fetal plasma CRH concentrations in uncomplicated pregnancies. In the present study we have measured CRH by radioimmunoa...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(95)90095-0
更新日期:1995-06-01 00:00:00
abstract::The morphometric oxygen diffusive conductance (D(p)) of the placenta provides a measure of the efficiency of oxygen transfer between the mother and the developing fetus. Any change in the D(p)may point towards possible adaptation in the light of altered oxygen transfer. Placentae from normal (n=40) and small for gesta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00044-4
更新日期:2003-07-01 00:00:00
abstract::Oestrogen and progesterone receptors have been implicated in human placental steroidogenesis, but studies developed to measure their concentration in this tissue at term yielded discrepant results. Potential inaccuracy of the binding assays, the technique used in previous studies, might influence the discrepancy. In t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(89)90049-0
更新日期:1989-11-01 00:00:00