Fibulin-5 is upregulated in decidualized human endometrial stromal cells and promotes primary human extravillous trophoblast outgrowth.


:Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrophoblasts. We aimed to determine the expression and immunolocalization of FBLN5 in human first trimester decidua and examine the effect of FBLN5 in trophoblast invasion in vitro using a first trimester placental villous outgrowth assay. We demonstrated that FBLN5 mRNA expression is upregulated in response to cAMP-mediated decidualization of primary human endometrial stromal cells, although FBLN5 itself does not enhance decidualization. We reported for the first time, FBLN5 protein production in first trimester decidual cells and also co-localization to HLAG-positive EVTs in first trimester decidua. Consequently, we investigated the effects of exogenous FBLN5 on placental villous outgrowth in vitro and demonstrated that FBLN5 promotes EVT migration/invasion. This is the first study to identify FBLN5 in decidualized human endometrial stromal cells, first trimester decidua and EVT and determine a functional role for FBLN5 in human EVTs, suggesting that decidual and or EVT-derived FBLN5 regulates EVT invasion and placentation in women.






Winship A,Cuman C,Rainczuk K,Dimitriadis E




Has Abstract


2015-12-01 00:00:00
















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    pub_type: 杂志文章


    authors: Wood GW

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    pub_type: 杂志文章,评审


    authors: Cole LA

    更新日期:2007-10-01 00:00:00

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    authors: Jirkovská M,Janácek J,Kaláb J,Kubínová L

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    authors: Ansari T,Fenlon S,Pasha S,O'Neill B,Gillan JE,Green CJ,Sibbons PD

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    authors: Shen F,Wei J,Snowise S,DeSousa J,Stone P,Viall C,Chen Q,Chamley L

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    authors: Lappas M,Lim R,Riley C,Menon R,Permezel M

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    authors: Price HR,Chehroudi C,Knight SJ,Smith AD,Lai D,Kim H,Wright TE,Coughtrie MW,Collier AC

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    authors: Toledo MT,Gomes Marcondes MC

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    authors: Gascoin-Lachambre G,Buffat C,Rebourcet R,Chelbi ST,Rigourd V,Mondon F,Mignot TM,Legras E,Simeoni U,Vaiman D,Barbaux S

    更新日期:2010-02-01 00:00:00

  • Aberrantly up-regulated miR-142-3p inhibited the proliferation and invasion of trophoblast cells by regulating FOXM1.

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    pub_type: 杂志文章


    authors: Mao Y,Hou B,Shan L,Sun X,Wang L

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  • Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus.

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    pub_type: 杂志文章


    authors: Beltrame JS,Sordelli MS,Cella M,Perez Martinez S,Franchi AM,Ribeiro ML

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    pub_type: 杂志文章


    authors: Acevedo CG,Rojas S,Ramirez M,Bravo I

    更新日期:1995-10-01 00:00:00

  • IFPA Meeting 2013 Workshop Report III: maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

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    authors: Abumaree MH,Brownbill P,Burton G,Castillo C,Chamley L,Croy BA,Drewlo S,Dunk C,Girard S,Hansson S,Jones S,Jurisicova A,Lewis R,Letarte M,Parast M,Pehrson C,Rappolee D,Schneider H,Tannetta D,Varmuza S,Wadsack C,Wa

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    authors: Sobrevia L,Abarzúa F,Nien JK,Salomón C,Westermeier F,Puebla C,Cifuentes F,Guzmán-Gutiérrez E,Leiva A,Casanello P

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    pub_type: 杂志文章


    authors: Van Meir CA,Ramirez MM,Matthews SG,Calder AA,Keirse MJ,Challis JR

    更新日期:1997-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Poisner AM,Thrailkill K,Poisner R,Handwerger S

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    pub_type: 杂志文章,评审


    authors: James JL,Carter AM,Chamley LW

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  • IFPA meeting 2008 workshops report.

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    authors: Lash GE,Ansari T,Bischof P,Burton GJ,Chamley L,Crocker I,Dantzer V,Desoye G,Drewlo S,Fazleabas A,Jansson T,Keating S,Kliman HJ,Lang I,Mayhew T,Meiri H,Miller RK,Nelson DM,Pfarrer C,Roberts C,Sammar M,Sharma S,

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    pub_type: 杂志文章


    authors: Evans L,Myatt L

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    pub_type: 杂志文章


    authors: Bennett FI,Jackson AA

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  • The hopes and fears of in utero gene therapy for genetic disease--a review.

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    pub_type: 杂志文章,评审


    authors: Coutelle C,Themis M,Waddington S,Gregory L,Nivsarkar M,Buckley S,Cook T,Rodeck C,Peebles D,David A

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  • Evidence of sexual dimorphism in the placental function with severe preeclampsia.

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    pub_type: 杂志文章


    authors: Muralimanoharan S,Maloyan A,Myatt L

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    pub_type: 杂志文章


    authors: Douglas GC,King BF

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    pub_type: 杂志文章


    authors: Talaulikar VS,Bax BE,Page NM,Manyonda I

    更新日期:2012-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Boockfor FR,Harris SE,Barto JM,Bonner JM

    更新日期:1994-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Meng YH,Li H,Chen X,Liu LB,Shao J,Chang KK,Du MR,Jin LP,Li MQ,Li DJ

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    pub_type: 杂志文章


    authors: Fonseca BM,Teixeira NA,Almada M,Taylor AH,Konje JC,Correia-da-Silva G

    更新日期:2011-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Colecchi C,Partemi S,Minelli N,Cascini F,Rossi R,Fulcheri E,Pascali VL,Oliva A

    更新日期:2011-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Racca AC,Ridano ME,Bandeira CL,Bevilacqua E,Avvad Portari E,Genti-Raimondi S,Graham CH,Panzetta-Dutari GM

    更新日期:2016-09-01 00:00:00