Abstract:
:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs are involved in agonist-induced constriction of fetoplacental resistance vessels and that their contribution is modulated by oxygen. Chorionic plate small arteries were studied using wire myography. Arteries were normalised at high (0.9 of L(13.3 kPa)) or low (0.9 of L(5.1 kPa)) stretch and experiments performed at 156, 38 or 15 mmHg oxygen. At low stretch, U46619 (thromboxane-mimetic) or KCl (smooth muscle depolarisation) constriction was greater at 38 than 156 or 15 mmHg oxygen. An L-type VGCC blocker nifedipine, inhibited KCl constriction by >85% but was less effective in U46619 constrictions (43-67%). At high stretch, nifedipine inhibition of KCl- and U46619-induced constriction was less at 15 than 38 or 156 mmHg oxygen. Oxygen did not affect constriction to U46619 or nifedipine-induced relaxation when vessels were normalised at high stretch. In conclusion, oxygen modulates chorionic plate arterial constriction at low stretch but regulation is lost at high stretch. U46619 constriction is underlain by VGCCs and nifedipine-insensitive processes; their relative contribution is influenced by oxygen.
journal_name
Placentajournal_title
Placentaauthors
Cooper EJ,Wareing M,Greenwood SL,Baker PNdoi
10.1016/j.placenta.2005.04.012keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
402-10issue
4-5eissn
0143-4004issn
1532-3102pii
S0143-4004(05)00137-2journal_volume
27pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP recept...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.06.005
更新日期:2005-02-01 00:00:00
abstract::Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80020-4
更新日期:1983-01-01 00:00:00
abstract::Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammat...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.09.015
更新日期:2013-12-01 00:00:00
abstract::Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(96)90061-2
更新日期:1996-07-01 00:00:00
abstract::Pregnancy induces a number of alterations to maternal physiology to accommodate the increased demands made by the developing fetus and placenta. These alterations appear at least in part to be driven by products derived from the feto-placental unit, including microchimeric cells, as well as placental exosomes and micr...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.11.005
更新日期:2012-02-01 00:00:00
abstract::Wharton's jelly contains large amounts of hyaluronic acid, and glucosamine is an important constituent of this macromolecule. In order to evaluate the placental vascular effects of this aminosugar, small chorionic and stem villous arteries were dissected from placental specimens obtained at normal term vaginal deliver...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90069-5
更新日期:1987-07-01 00:00:00
abstract:INTRODUCTION:Preterm birth is a heterogeneous phenotype, with placental abnormalities underlying many cases. The etiology of preterm births that occur in the absence of placental abnormalities, however, remain enigmatic and we considered that early pregnancy biomarkers may provide clues. METHODS:Women from a hospital-...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.12.007
更新日期:2020-01-01 00:00:00
abstract::The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2016.11.008
更新日期:2017-04-01 00:00:00
abstract::The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2019.02.013
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:miRNAs are small non-coding RNAs important for the regulation of mRNA in many organs including placenta. Adipokines and specifically leptin are known to be dysregulated in preeclampsia, but little is known regarding their regulation by miRNAs during pregnancy. METHODS:We performed high-throughput sequenci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.07.002
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:We have identified some critical aspects concerning umbilical cord tissue mesenchymal stem cells: the lack of standards for cell isolation, expansion and cryopreservation, the lack of unanimous opinions upon their multilineage differentiation potential and the existence of very few results related to the f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.08.011
更新日期:2015-10-01 00:00:00
abstract::Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.01.017
更新日期:2012-05-01 00:00:00
abstract::The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(95)90013-6
更新日期:1995-12-01 00:00:00
abstract::The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.02.004
更新日期:2005-04-01 00:00:00
abstract::Glycogen storage disease type IV (GSD IV) is a rare autosomal recessive disorder caused by glycogen branching enzyme (GBE) deficiency and resulting in the storage of abnormal glycogen (polyglucosan). Prenatal diagnosis is based on biochemical assay of GBE activity or on mutation analysis, but polyglucosan can also be ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.01.005
更新日期:2008-04-01 00:00:00
abstract::Human placental villi from both normal and complicated pregnancies were examined by both light and scanning electron microscopy. The findings provide evidence that histological features such as syncytial sprouts, bridges, and a net-like arrangement of villi represent tangential sections of irregularly shaped villi rat...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90047-6
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:Maternal magnesium (Mg) deficiency has been associated with fetal growth restriction. Using a mouse model of maternal Mg deficiency-induced fetal growth restriction, we sought to investigate the effect of Mg deficiency on placental physiology and function. METHODS:In vivo: Pregnant Swiss Webster mice were fe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.01.009
更新日期:2016-03-01 00:00:00
abstract::The sites of localization of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), adrenocorticotrophic hormone (ACTH) and prolactin (PRL) within placental tissues have been studied by an immunoperoxidase technique. The syncytiotrophoblast is the sole significant site of localization of LH...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(86)80007-8
更新日期:1986-03-01 00:00:00
abstract::Nitrotyrosine residues (NT), an index of oxidative stress arising from peroxynitrite formation and action, are found in placental vasculature of pregnancies complicated by pre-eclampsia (PE) or pregestational insulin-dependent diabetes mellitus (IDDM). This study correlates conventional placental pathology with NT imm...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0634
更新日期:2001-04-01 00:00:00
abstract:INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.03.015
更新日期:2014-06-01 00:00:00
abstract::The localization of 5-hydroxytryptamine (5-HT) and its receptors in human placenta was studied under light and electron microscopy using immunohistochemistry and in situ hybridization. The syncytiotrophoblast, cytotrophoblast, stromal cells and decidual cells in human placentae all appeared to be 5-HT immunoreactive. ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90027-3
更新日期:1998-11-01 00:00:00
abstract::Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2010.02.010
更新日期:2010-05-01 00:00:00
abstract::Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits troph...
journal_title:Placenta
pub_type: 杂志文章,收录出版
doi:10.1016/j.placenta.2017.03.008
更新日期:2017-05-01 00:00:00
abstract::During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia Inducible Factors (HIF) are t...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2010.08.008
更新日期:2010-11-01 00:00:00
abstract::Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.022
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:Scant data on placental lymphatic vessels have pointed to the absence of lymphatic circulation. A recent study on mesenchymal dysplasia (MD), however, has identified pathologic lymphangiogenesis using the D2-40 lymphatic marker. These conflicting data have prompted us to investigate whether lymphatic vessels...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.01.013
更新日期:2011-04-01 00:00:00
abstract::Receptors for complexes between alpha 2-macroglobulin (alpha 2M) and proteinases (e.g. trypsin) were identified and characterized in the human placenta. The receptors also bound the complex formed between pregnancy zone protein (PZP) and chymotrypsin, although with slightly lower affinity, whereas binding of alpha 2M ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90019-7
更新日期:1988-09-01 00:00:00
abstract:INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.11.001
更新日期:2019-01-01 00:00:00
abstract::Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00104-8
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.031
更新日期:2020-11-14 00:00:00