Early pregnancy immune profile and preterm birth classified according to uteroplacental lesions.

abstract：INTRODUCTION:Pregnancy complicated by diabetes mellitus (DM) is a central obstetric problem often complicated by fetal macrosomia and increased risk of intrapartum asphyxia. This risk might be explained by fetoplacental vascular abnormalities. This study aimed to investigate the fetoplacental vascular volume by placent...

journal_title：Placenta

authors： Thunbo MØ,Sinding M,Bogaard P,Korsager AS,Frøkjær JB,Østergaard LR,Petersen A,Sørensen A

更新日期：2018-09-01 00:00:00

abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...

journal_title：Placenta

authors： Duncan JR,Cock ML,Rees S,Harding R

更新日期：2003-08-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

journal_title：Placenta

authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

更新日期：2020-11-14 00:00:00

abstract：:Two groups of placentae from 18 cases of maternal rubella were examined morphologically and virologically. Placentae in Group I (four cases) had a mean gestational age of 21 +/- 1.9 weeks, whilst those in Group 2 (14 cases) had a mean gestational age of 38 +/- 2.8 weeks. A tendency to hypoplasia was observed. The micr...

journal_title：Placenta

authors： Garcia AG,Marques RL,Lobato YY,Fonseca ME,Wigg MD

更新日期：1985-07-01 00:00:00

abstract：:The EAT/mcl-1 gene was isolated during the early differentiation of a retinoic acid-induced human embryonal carcinoma cell line to the trophectoderm lineage. EAT/mcl-1, a bcl-2 related gene, is involved in the genetic pathway of apoptosis; this suggests a role for apoptosis and the involvement of this gene in early pl...

journal_title：Placenta

authors： Suzuki A,Umezawa A,Sano M,Nozawa S,Hata J

更新日期：2000-03-01 00:00:00

abstract：:Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development. In this study, we first confirmed these findings using cRNA probes for TF, and then adapted the TF reverse haemolytic plaque ...

journal_title：Placenta

authors： Boockfor FR,Harris SE,Barto JM,Bonner JM

更新日期：1994-07-01 00:00:00

abstract：:Maternal infection of Trypanosoma cruzi is associated with premature births, abortions and placentitis. A decrease in EGF levels has been suggested to occur in animals infected by T. cruzi, but there is no research about the levels of EGF in human patients with Chagas' disease. We evaluated serum EGF levels in pregnan...

journal_title：Placenta

authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...

journal_title：Placenta

authors： Tsur A,Kalish F,Burgess J,Nayak NR,Zhao H,Casey KM,Druzin ML,Wong RJ,Stevenson DK

更新日期：2019-01-01 00:00:00

abstract：:Peroxidase (Donor: H(2)O(2)oxidoreductase EC 1.11.1.7) from human term placentae of non-smokers was purified to homogeneity by a combination of NH(4)Cl extraction, affinity chromatography, (NH(4))(2)SO(4)precipitation, ion-exchange and gel filtration chromatography. The homogeneity of purified human placental peroxida...

journal_title：Placenta

authors： Madhavan ND,Naidu KA

更新日期：2000-07-01 00:00:00

abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

journal_title：Placenta

authors： Loke YW,King A

更新日期：1990-07-01 00:00:00

abstract：:The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...

journal_title：Placenta

authors： Hou YP,Gu JY,Shao YF,Song YF,Jing YH,Wu WS,Pu S

更新日期：2011-03-01 00:00:00

abstract：:Amino acid transfer to the fetus is dependent on several different factors. While these factors can be understood in isolation, it is still not possible to predict the function of the system as a whole. In order to do this an integrated approach is required which incorporates the interactions between the different det...

journal_title：Placenta

authors： Lewis RM,Brooks S,Crocker IP,Glazier J,Hanson MA,Johnstone ED,Panitchob N,Please CP,Sibley CP,Widdows KL,Sengers BG

更新日期：2013-03-01 00:00:00

abstract：:The keratin cytoskeleton is present in all trophoblast cell subtypes of the mouse and human placenta and is required to maintain the structural integrity of these cells. Recently, various genetic mouse models have shown that a normal keratin network is necessary for placental development. Keratin-deficiency leads to t...

journal_title：Placenta

authors： Watson ED

更新日期：2007-04-01 00:00:00

abstract：:The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...

journal_title：Placenta

authors： Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani K

更新日期：2014-11-01 00:00:00

abstract：:Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...

journal_title：Placenta

authors： Winship A,Cuman C,Rainczuk K,Dimitriadis E

更新日期：2015-12-01 00:00:00

abstract：:Human parvovirus B19 (B19) infection during pregnancy can result in horizontal transmission of the virus and congenital infection. The main targets for B19 replication are the erythroid precursor cell of the colony and burst forming units. The cellular receptor necessary for B19 infectivity is globoside. Other non-ery...

journal_title：Placenta

authors： Jordan JA,Butchko AR

更新日期：2002-08-01 00:00:00

abstract：:The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles...

journal_title：Placenta

authors： Tannetta D,Collett G,Vatish M,Redman C,Sargent I

更新日期：2017-04-01 00:00:00

abstract：:Recent studies have indicated that oxidative stress is involved in the pathogenesis of pre-eclampsia. Oxidative stress damages systemic tissues, and placental damage may result in intrauterine growth retardation and fetal distress. Thus, this study attempted to elucidate the placental localization of thioredoxin and t...

journal_title：Placenta

authors： Ejima K,Nanri H,Toki N,Kashimura M,Ikeda M

更新日期：1999-01-01 00:00:00

abstract：:The intrauterine environment has an important influence on placental development. In pre-eclampsia (PE) and intrauterine growth restriction (IUGR), early remodelling of spiral arteries has repercussions for uteroplacental blood flow. The IUGR placenta exhibits compromised growth of villous trees, a smaller intervillou...

journal_title：Placenta

authors： Rainey A,Mayhew TM

更新日期：2010-07-01 00:00:00

abstract：AIMS:Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. METHODS:This was a...

journal_title：Placenta

authors： Kulkarni A,Garcia-Cañadilla P,Khan A,Lorenzo JM,Beckerman K,Valenzuela-Alcaraz B,Cruz-Lemini M,Gomez O,Gratacos E,Crispi F,Bijnens B

更新日期：2018-03-01 00:00:00

abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...

journal_title：Placenta

authors： Poisner AM,Thrailkill K,Poisner R,Handwerger S

更新日期：1991-05-01 00:00:00

abstract：:Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been associated with pregnancy disorders, such as recurrent miscarriages, intrauterine growth retardation, and pre-eclampsia. The aim of this study was t...

journal_title：Placenta

authors： Zhao H,Wong RJ,Kalish FS,Nayak NR,Stevenson DK

更新日期：2009-10-01 00:00:00

abstract：:Homogenates of first (10.1 +/- 1.0 weeks) and third trimester placental villi were analysed for free amino acid concentrations. As has been previously reported, several amino acids showed increased concentrations during early pregnancy when compared to term. In addition, marked differences were seen in the levels of e...

journal_title：Placenta

authors： Sooranna SR,Burston D,Ramsay B,Steer PJ

更新日期：1994-10-01 00:00:00

abstract：:The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...

journal_title：Placenta

authors： Rhon-Calderon EA,Vrooman LA,Riesche L,Bartolomei MS

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Air pollution has significant negative health impacts, particularly on the cardiovascular system. The aims of this narrative review were to identify whether there is an association between air pollution and the incidence of pre-eclampsia, and the potential mechanisms by which any effects may be mediated. ...

journal_title：Placenta

authors： Bearblock E,Aiken CE,Burton GJ

更新日期：2020-12-18 00:00:00

abstract：:Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

journal_title：Placenta

authors： Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

更新日期：1989-03-01 00:00:00

abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

journal_title：Placenta

authors： Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

更新日期：2005-11-01 00:00:00

abstract：:Confocal and conventional indirect immunofluorescence and immunogold electron microscopic methods were applied to examine the distribution of extracellular matrix constituents (collagens types III and IV) in the villi of immature and term human placentae. The immunofluorescence study revealed that collagen type III is...

journal_title：Placenta

authors： Nanaev AK,Rukosuev VS,Shirinsky VP,Milovanov AP,Domogatsky SP,Duance VC,Bradbury FM,Yarrow P,Gardiner L,d'Lacey C

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...

journal_title：Placenta

authors： Salafia CM,Yampolsky M,Shlakhter A,Mandel DH,Schwartz N

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....

journal_title：Placenta

authors： Morosin SK,Delforce SJ,Lumbers ER,Pringle KG

更新日期：2020-08-01 00:00:00