Abstract:
:The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles, released from the surface of the placenta directly into the maternal circulation, in the form of exosomes, microvesicles and apoptotic bodies. They carry many syncytiotrophoblast derived factors such as proteins, lipids, glycans and nucleic acids, which together could dynamically signal to the mother the status of the placenta. We review STBEV research and discuss the potential for STBEV to be used as circulating syncytiotrophoblast biopsies, accessible via a simple blood sample throughout pregnancy, giving a real-time readout of syncytiotrophoblast health. We also highlight advances in the use of extracellular vesicles as circulating tumour derived biopsies in the field of cancer research, which could prove beneficial to obstetric care.
journal_name
Placentajournal_title
Placentaauthors
Tannetta D,Collett G,Vatish M,Redman C,Sargent Idoi
10.1016/j.placenta.2016.11.008subject
Has Abstractpub_date
2017-04-01 00:00:00pages
134-138eissn
0143-4004issn
1532-3102pii
S0143-4004(16)30637-3journal_volume
52pub_type
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