Umbilical cord as an analytical matrix - A technical note.

Abstract:

:The umbilical cord (UC) connects the fetal blood supply to the placenta, so is exposed to all systemic endo- and xenobiotics. We have extensive experience using UC as an analytical matrix for detecting and/or quantitating drugs, chemicals and endogenous compounds. This technical note describes advantages (large amount available, ease of collection, small sample needed for use, rapid availability) and challenges (clinical relationships, processing difficulties, matrix effects on analytes and detection technologies) of UC as an analytical matrix in ELISA and LC/MS platforms, and provides guidance for successfully working with this tissue.

journal_name

Placenta

journal_title

Placenta

authors

Price HR,Chehroudi C,Knight SJ,Smith AD,Lai D,Kim H,Wright TE,Coughtrie MW,Collier AC

doi

10.1016/j.placenta.2019.12.001

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

42-44

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(19)30712-X

journal_volume

90

pub_type

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