Abstract:
:The umbilical cord (UC) connects the fetal blood supply to the placenta, so is exposed to all systemic endo- and xenobiotics. We have extensive experience using UC as an analytical matrix for detecting and/or quantitating drugs, chemicals and endogenous compounds. This technical note describes advantages (large amount available, ease of collection, small sample needed for use, rapid availability) and challenges (clinical relationships, processing difficulties, matrix effects on analytes and detection technologies) of UC as an analytical matrix in ELISA and LC/MS platforms, and provides guidance for successfully working with this tissue.
journal_name
Placentajournal_title
Placentaauthors
Price HR,Chehroudi C,Knight SJ,Smith AD,Lai D,Kim H,Wright TE,Coughtrie MW,Collier ACdoi
10.1016/j.placenta.2019.12.001subject
Has Abstractpub_date
2020-01-15 00:00:00pages
42-44eissn
0143-4004issn
1532-3102pii
S0143-4004(19)30712-Xjournal_volume
90pub_type
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