Abstract:
:Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = -193.71, p = 0.016), particularly in preterm group (coef = -374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM.
journal_name
Placentajournal_title
Placentaauthors
Oktavianthi S,Fauzi M,Trianty L,Trimarsanto H,Bowolaksono A,Noviyanti R,Malik SGdoi
10.1016/j.placenta.2019.03.005subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1-3eissn
0143-4004issn
1532-3102pii
S0143-4004(19)30051-7journal_volume
80pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.03.007
更新日期:2011-06-01 00:00:00
abstract:UNLABELLED:Placental hypoxia has been implicated in pregnancy pathologies such as preeclampsia. We have previously reported that AQP9 is highly expressed in syncytiotrophoblast from normal placentas and shows an overexpression in preeclamptic placentas, with a lack of functionality for water transport. Up to now, the r...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.017
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Scant data on placental lymphatic vessels have pointed to the absence of lymphatic circulation. A recent study on mesenchymal dysplasia (MD), however, has identified pathologic lymphangiogenesis using the D2-40 lymphatic marker. These conflicting data have prompted us to investigate whether lymphatic vessels...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.01.013
更新日期:2011-04-01 00:00:00
abstract::Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been associated with pregnancy disorders, such as recurrent miscarriages, intrauterine growth retardation, and pre-eclampsia. The aim of this study was t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.07.012
更新日期:2009-10-01 00:00:00
abstract::Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.008
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.11.001
更新日期:2019-01-01 00:00:00
abstract::The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.02.004
更新日期:2005-04-01 00:00:00
abstract::A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from sever...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90052-x
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:Histologic placental and/or intra-amniotic inflammation is frequently documented during ascending intra-uterine infections in patients with preterm labor and intact membranes. Placenta previa can be a clinical situation that shows the successive schema of histologic placental and intra-amniotic inflammation d...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.04.005
更新日期:2009-07-01 00:00:00
abstract::A rapid method to determine quality for placental proteomic studies is required due to varying lengths of time between delivery and sampling in routine protocols. We developed a rapid 10 min LC-MS based scanning method to profile free peptides liberated from natural proteolytic degradation. The assay was applied to pl...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.04.014
更新日期:2016-08-01 00:00:00
abstract::Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00104-8
更新日期:2003-08-01 00:00:00
abstract::Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.11.005
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Very few studies have measured the weight of large numbers of placentas delivered before the 28th post-menstrual week. METHODS:We measured the weight of 930 singleton placentas delivered before the 28th post-menstrual week, and examined the distributions of weights in selected groups (week of gestation, reason...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2007.04.009
更新日期:2007-10-01 00:00:00
abstract:INTRODUCTION:The placenta is a transient organ the functioning of which has health consequences far beyond the embryo/fetus. Understanding the biology of any system (organ, organism, single cell, etc) requires a comprehensive and inclusive approach which embraces all the biomedical disciplines and 'omic' technologies a...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2015.01.001
更新日期:2015-04-01 00:00:00
abstract::The visceral yolk sac (VYS) is responsible for a major part of the amino acid nutrition of the early post-implantation rat embryo and possibly also at the fetal stage of gestation. The mechanism involves endocytic uptake of proteins by the tissue's epithelial cells followed by intralysosomal digestion to amino acids. ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(77)90009-1
更新日期:1997-09-01 00:00:00
abstract::Abnormalities in glucose metabolism linked to D-chiro-inostol phosphoglycans (IPGs) have been described in human placentas of preeclamptic women. In this study, a semi-quantitative approach to assess the histological assessment of IPGs revealed no significant differences between early and late onset preeclampsia and g...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.07.007
更新日期:2012-10-01 00:00:00
abstract::Preeclampsia is a leading cause of maternal and fetal morbidity and mortality in high and low-income countries. The aetiology of preeclampsia is multifactorial and remains obscure. Some evidences suggest that altered placental fatty acid oxidation might play a role in the pathogenesis of preeclampsia. To reveal if pla...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.11.027
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder unique to pregnancy that is associated with increased rates of fetal distress and demise. While acute hypoxia is believed to cause the pathophysiology of ICP, direct molecular evidence for this is lacking. Here, we analyzed expression of three...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.06.372
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.03.015
更新日期:2014-06-01 00:00:00
abstract::In view of the pathological placental features of pre-eclampsia and intrauterine growth restriction (IUGR), and the angiogenic effects of vascular endothelial growth factor (VEGF), the aim of this study was to determine the expression of VEGF in placentae from normal pregnancies and to compare the results with placent...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80061-6
更新日期:1997-05-01 00:00:00
abstract::An area of the fetal membranes, within the rupture tear after spontaneous delivery at term, exhibits altered morphology compared to more distal sites. It is characterized by marked swelling of the amniotic and chorionic connective tissue layers, consistent with structural weakness, and a marked reduction of the thickn...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0439
更新日期:2000-01-01 00:00:00
abstract::A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.03.015
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Notch signalling has been shown to control cytotrophoblast (CTB) proliferation, differentiation and motility suggesting that the conserved signalling pathway could be critical for human placental development. Since individual Notch receptors have not been elucidated, we herein investigated expression patte...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.01.009
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.02.005
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Dietrich Starck (1908-2001) was a German embryologist who wrote extensive reviews on comparative placentation. FINDINGS:Starck's embryology textbook and his comprehensive review of comparative embryology and placentation give excellent insights into the foundational literature and are extensively referenced...
journal_title:Placenta
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.placenta.2017.08.073
更新日期:2017-10-01 00:00:00
abstract::The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.018
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.031
更新日期:2020-11-14 00:00:00
abstract:OBJECTIVES:To compare the distribution of placental protein 13 (PP13) in fetal and maternal blood and amnionic fluid and to correlate it with PP13 protein and mRNA in the placenta. METHODS:Umbilical arterial serum, amnionic fluid, maternal venous serum and placental tissues were collected from normal outcome pregnanci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.09.006
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.002
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Placenta previa is a severe pregnancy complication with considerable maternal and neonatal morbidity. Placenta previa can be defined as major or minor by location. Major placenta previa is associated with higher complication rates. Management of women with minor placenta previa has not been well defined. T...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.08.080
更新日期:2019-09-15 00:00:00