Abstract:
:Human placental fragments concentrate 86Rb 10--20-fold during a two-hour incubation period. Inhibition of ouabain is dose-dependent, reaching 90 + per cent at a concentration of 5 x 10(-5) M. The clearance index of 86Rb across the perfused human placenta is 0.34 +/- 0.08, comparing to previously reported indices for Na22 and Cl36 of 0.28 and 0.41, respectively. Ouabain in concentrations up to 5 x 10(-5) M had no detectable effect on transfer across the placenta. The clearance index of ouabain is low, averaging 0.07 in 3 experiments. 3H-ouabain is not detectably bound to albumin or placental homogenate.
journal_name
Placentajournal_title
Placentaauthors
Dancis J,Kammerman S,Jansen V,Levitz Mdoi
10.1016/s0143-4004(83)80038-1subject
Has Abstractpub_date
1983-10-01 00:00:00pages
351-9issue
4eissn
0143-4004issn
1532-3102pii
S0143-4004(83)80038-1journal_volume
4pub_type
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