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The expression of connective tissue growth factor in pregnancies complicated by severe preeclampsia or fetal growth restriction.

Abstract：

:We tested the hypothesis that the expression of placental connective tissue growth factor (CTGF) is enhanced in pregnancies complicated by severe preeclampsia (PE) or fetal growth restriction (FGR). CTGF expression was analyzed using immunostaining, western blot and real-time quantitative PCR in placental samples obtained after third trimester cesarean deliveries without labor from women with severe PE (n=11), idiopathic FGR (n=14), or healthy controls (n=14). Serum CTGF concentrations were analyzed using ELISA. We found that CTGF was stably expressed in villous trophoblasts throughout pregnancy. The expression of CTGF mRNA in placentas from severe PE or FGR was higher than placentas from controls. Whereas the levels of placental CTGF protein were similar between normal and severe PE, maternal and fetal serum CTGF levels were elevated in severe PE. Maternal CTGF levels were also distinctively elevated in women with PE or FGR with histological evidence of placental injury. The enhancement of CTGF expression as well as serum CTGF levels in clinical conditions attributed to placental dysfunction suggests a role for this secretary protein in the pathophysiology of placental injury or its sequelae.

journal_name

Placenta

journal_title

Placenta

authors

Oh SY,Song SE,Seo ES,Kim KH,Choi SJ,Suh YL,Sadovsky Y,Roh CR

doi

10.1016/j.placenta.2009.08.006

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

981-7

issue

11

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(09)00271-9

journal_volume

30

pub_type

杂志文章

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