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Leptin expression in the fetus and placenta during mouse pregnancy.

Abstract：

:During pregnancy, leptin concentrations in the maternal circulation are elevated in both humans and rodents but decrease to pre-pregnancy levels at birth, suggesting a role for leptin in the maintenance of pregnancy. Synthesis of leptin by the human placenta is established but whether the murine placenta synthesizes leptin remains controversial. The aims of this study were to determine (a) if the mouse wild-type placenta expresses the ob gene using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and (b) whether the mouse fetus and placenta contribute to the significant increase of leptin in the maternal circulation during pregnancy. The mouse placenta did not express the ob gene at a level that could be readily detected using RT-PCR. Moreover, both maternal gain in weight and undetectable concentrations of leptin in sera in leptin-deficient ob/ob mothers bearing heterozygote (ob/+) fetuses suggested that the mouse fetus and placenta do not make a significant contribution to the dramatic increase in maternal plasma concentrations of leptin during late gestation. It is therefore concluded that neither fetal- nor placental-derived leptin modulates maternal weight gain during pregnancy.

journal_name

Placenta

journal_title

Placenta

authors

Malik NM,Carter ND,Wilson CA,Scaramuzzi RJ,Stock MJ,Murray JF

doi

10.1016/j.placenta.2004.03.009

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

47-52

issue

1

eissn

0143-4004

issn

1532-3102

pii

S0143400404001031

journal_volume

26

pub_type

杂志文章

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