Gene targeting in primary human trophoblasts.

abstract：INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....

journal_title：Placenta

authors： Morosin SK,Delforce SJ,Lumbers ER,Pringle KG

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta. METHODS:Transfer of...

journal_title：Placenta

authors： Day PE,Cleal JK,Lofthouse EM,Hanson MA,Lewis RM

更新日期：2013-10-01 00:00:00

abstract：:Peroxidase (Donor: H(2)O(2)oxidoreductase EC 1.11.1.7) from human term placentae of non-smokers was purified to homogeneity by a combination of NH(4)Cl extraction, affinity chromatography, (NH(4))(2)SO(4)precipitation, ion-exchange and gel filtration chromatography. The homogeneity of purified human placental peroxida...

journal_title：Placenta

authors： Madhavan ND,Naidu KA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:To compare the distribution of placental protein 13 (PP13) in fetal and maternal blood and amnionic fluid and to correlate it with PP13 protein and mRNA in the placenta. METHODS:Umbilical arterial serum, amnionic fluid, maternal venous serum and placental tissues were collected from normal outcome pregnanci...

journal_title：Placenta

authors： Sammar M,Nisemblat S,Fleischfarb Z,Golan A,Sadan O,Meiri H,Huppertz B,Gonen R

更新日期：2011-02-01 00:00:00

abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

journal_title：Placenta

authors： Loke YW,King A

更新日期：1990-07-01 00:00:00

abstract：:The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...

journal_title：Placenta

authors： Kwek K,Read MA,Khong TY,Bisits AT,Walters WA

更新日期：2001-07-01 00:00:00

abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...

journal_title：Placenta

authors： Braun T,Husar A,Challis JR,Dudenhausen JW,Henrich W,Plagemann A,Sloboda DM

更新日期：2013-05-01 00:00:00

abstract：:Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...

journal_title：Placenta

authors： Ying X,Zhu Y,Jin X,Chang X

更新日期：2020-10-20 00:00:00

abstract：OBJECTIVES:In maternal diabetes the placenta is large with abnormal vascular development and increased villous volume. We used a novel stereological 3D power Doppler ultrasound technique to investigate differences in-vivo in the placental fractional volume of power Doppler signal (FrVol-PD) between women with and witho...

journal_title：Placenta

authors： Jones NW,Deshpande R,Mousa HA,Mansell P,Raine-Fenning N,Bugg G

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...

journal_title：Placenta

authors： Cappelletti M,Giannelli S,Martinelli A,Cetin I,Colombo E,Calcaterra F,Mavilio D,Della Bella S

更新日期：2013-01-01 00:00:00

abstract：:The hormone leptin (OB) and its receptor (OB-R) are key homeostatic regulators of mammalian body weight. Two predominant isoforms of OB-R are expressed by alternative splicing: the long form, OB-RL, with full signalling capacity is highly expressed in the hypothalamus and the short, signalling-defective form, OB-Rs, i...

journal_title：Placenta

authors： Ebenbichler CF,Kaser S,Laimer M,Wolf HJ,Patsch JR,Illsley NP

更新日期：2002-07-01 00:00:00

abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

journal_title：Placenta

authors： Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

更新日期：2001-05-01 00:00:00

abstract：:Direct measurements of electrical potential and input resistance were performed on the syncytial membrane facing maternal blood. The potentials varied according to the external potassium ion levels and, to a lesser extent, with sodium ion concentrations. Ouabain provoked a rapid and consistent depolarization which ind...

journal_title：Placenta

authors： Bara M,Challier JC,Guiet-Bara A

更新日期：1988-03-01 00:00:00

abstract：:Homeobox genes of the Distal-less (Dlx) family are expressed in the vertebrate embryo in regions where epithelial cell layers contact adjacent mesenchymal cells. This study shows that the human Dlx family member, DLX4, is expressed in the placenta, primarily in regions where epithelial and mesenchymal cell layers cont...

journal_title：Placenta

authors： Quinn LM,Latham SE,Kalionis B

更新日期：1998-01-01 00:00:00

abstract：:We have investigated whether maternal peripheral blood from the first trimester of pregnancy is a reliable source of identifiable trophoblast cells. The cells were enriched from 30 ml of venous blood, with multiple antibodies shown previously to enrich trophoblasts and a new cocktail based on known trophoblast surface...

journal_title：Placenta

authors： Schueler PA,Yamanishi DT,Pearson J,Lee Y,Wu X,Hashima S,Madlansacay MR,Cain CA,Collarini EJ,Foltz L,Mahoney W

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...

journal_title：Placenta

authors： Lei D,Deng N,Wang S,Huang J,Fan C

更新日期：2020-01-01 00:00:00

abstract：:Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...

journal_title：Placenta

authors： Cetin I,Cozzi V,Antonazzo P

更新日期：2008-10-01 00:00:00

abstract：:Eighty-one placentae from women with leprosy and 17 placentae from healthy controls were subjected to a detailed macroscopic, light microscopic, ultrastructural, immunopathological, microbiological and biochemical study. The placental morphology and immunohistology were normal, and there was no morphological evidence ...

journal_title：Placenta

authors： Duncan ME,Fox H,Harkness RA,Rees RJ

更新日期：1984-05-01 00:00:00

abstract：INTRODUCTION:The aim of this study is to determine whether the gene expression and associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived by assisted reproductive technologies (ART) compared to natural conceptions. METHODS:113 pregnancies were recruited resulting in 119 placentas (83 ...

journal_title：Placenta

authors： Sakian S,Louie K,Wong EC,Havelock J,Kashyap S,Rowe T,Taylor B,Ma S

更新日期：2015-10-01 00:00:00

abstract：:The implantation of the blastocyst and early development of the placenta are crucial for the success of implantation and pregnancy. However, the formative stages of human placental development are largely unknown because of their existence in a 'black box' where access to samples is extremely limited for ethical reaso...

journal_title：Placenta

authors： James JL,Carter AM,Chamley LW

更新日期：2012-05-01 00:00:00

abstract：:The recent discovery of a local renin-angiotensin system in trophoblastic tissues has raised many questions regarding its role in the physiology of normal gestation and its implications in the pathophysiology of hypertension during pregnancy. In this article, the authors first review the most interesting aspects of th...

journal_title：Placenta

authors： Kalenga MK,de Gasparo M,Thomas K,de Hertogh R

更新日期：1996-03-01 00:00:00

abstract：INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...

journal_title：Placenta

authors： Koppes E,Shaffer B,Sadovsky E,Himes K,Barak Y,Sadovsky Y,Chaillet JR

更新日期：2019-12-01 00:00:00

abstract：:The placental endothelium contributes to regulating transplacental exchange and maintaining the immunological maternofetal barrier. We characterized the endothelial phenotype in human normal term placentae with a panel of antibodies to endothelial antigens using a standardized immunofluorescence method. Placental endo...

journal_title：Placenta

authors： Dye JF,Jablenska R,Donnelly JL,Lawrence L,Leach L,Clark P,Firth JA

更新日期：2001-01-01 00:00:00

abstract：:We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...

journal_title：Placenta

authors： Chernyavsky IL,Jensen OE,Leach L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestatio...

journal_title：Placenta

authors： Vachon-Marceau C,Demers S,Markey S,Okun N,Girard M,Kingdom J,Bujold E

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:In humans, it is known that blood flow is directed to the gravid uterus from two (right and left) pelvic uterine arteries. The extent of supply from the tubo-ovarian anastomosis (joining of the ovarian and uterine arteries) is unknown. The aim of this study was to delineate the arterial blood supply to the p...

journal_title：Placenta

authors： Balasuriya H,Bell P,Waugh R,Thompson J,Gillin A,Hennessy A,Makris A

更新日期：2010-01-01 00:00:00

abstract：:The marginal zone of the human term placenta was studied by transmission electron microscopy and immunohistochemistry using antibodies against cytoskeletal filaments, extracellular matrix molecules and endothelial markers. The marginal sinus of the intervillous space is separated from the chorionic and basal plates by...

journal_title：Placenta

authors： Nanaev AK,Kosanke G,Kemp B,Frank HG,Huppertz B,Kaufmann P

更新日期：2000-01-01 00:00:00

abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...

journal_title：Placenta

authors： Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado M

更新日期：2016-11-01 00:00:00

abstract：:Endothelium derived relaxing factor (EDRF), now widely believed to be nitric oxide (NO), may play an important part in the control of fetoplacental vascular tone. To further explore this role we have determined the relaxation responses to exogenous NO and examined the temporal relationship between intracellular concen...

journal_title：Placenta

authors： Hull AD,White CR,Pearce WJ

更新日期：1994-06-01 00:00:00

abstract：INTRODUCTION:During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported ...

journal_title：Placenta

authors： Huynh J,Dawson D,Roberts D,Bentley-Lewis R

更新日期：2015-02-01 00:00:00