Abstract：
:Endothelium derived relaxing factor (EDRF), now widely believed to be nitric oxide (NO), may play an important part in the control of fetoplacental vascular tone. To further explore this role we have determined the relaxation responses to exogenous NO and examined the temporal relationship between intracellular concentrations of cyclic GMP and vascular tone in isolated ring segments of human chorionic plate arteries. We have also determined the dose relations for the contractile agonists serotonin and the thromboxane analog U46619. Lastly, we have explored the relaxation responses to a wide range of agents known to elicit EDRF release in other vascular beds. Chorionic plate arteries relaxed significantly to exogenous NO with concomitant increases in cyclic guanosine monophosphate over basal values. ED50s for serotonin and U46619 were 1.48 x 10(-6) M and 3.39 x 10(-8) M respectively. The ED50 for NO derived from S-nitroso-N-acetyl-penicillamine was 1.28 x 10(-6) M. Endothelium-intact segments of chorionic plate arteries pre-contracted with either serotonin or U46619 failed to relax significantly to acetylcholine, adenosine diphosphate, A23187, bradykinin, and histamine and only minimally to substance P. We suggest that EDRF is likely to be important in the control of placental vascular tone, but that it is not possible to demonstrate its action in an unperfused experimental system.
journal_name
Placentajournal_title
Placentaauthors
Hull AD,White CR,Pearce WJdoi
10.1016/0143-4004(94)90004-3subject
Has Abstractpub_date
1994-06-01 00:00:00pages
365-75issue
4eissn
0143-4004issn
1532-3102pii
0143-4004(94)90004-3journal_volume
15pub_type
杂志文章相关文献
PLACENTA文献大全abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.02.002
更新日期：2013-05-01 00:00:00
abstract：:Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.09.011
更新日期：2008-12-01 00:00:00
abstract：:The apoptosis cascade that plays a central role in normal and pathological processes is strictly controlled, in part by FLIP (Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein), an inhibitor of caspase-8. Here, we report the expression of long and short isoforms of FLIP mRNAs and ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2005.08.004
更新日期：2006-06-01 00:00:00
abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(03)00104-8
更新日期：2003-08-01 00:00:00
abstract：INTRODUCTION:Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.08.070
更新日期：2017-10-01 00:00:00
abstract：:The placenta provides all energy and nutrient requirements for healthy fetal development. The placenta in rats is capable of storing glycogen, although the placenta cells must therefore mobilize stored glycogen to its own glucose supply. Moreover, maternal glucose and/or placental lactate furnished the fetal growth. A...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2003.11.005
更新日期：2004-05-01 00:00:00
abstract：:Throughout its entire lifespan, the placenta is able to produce as well as respond to a variety of inflammatory stimuli. Many signaling molecules and concurrent pathways responsible for the propagation of an inflammatory response have been identified in placental cells. From early developmental stages onward, the secr...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2005.08.009
更新日期：2006-08-01 00:00:00
abstract：:The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2000.0582
更新日期：2000-11-01 00:00:00
abstract：:Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2015.11.006
更新日期：2016-03-01 00:00:00
abstract：:A rapid method to determine quality for placental proteomic studies is required due to varying lengths of time between delivery and sampling in routine protocols. We developed a rapid 10 min LC-MS based scanning method to profile free peptides liberated from natural proteolytic degradation. The assay was applied to pl...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.04.014
更新日期：2016-08-01 00:00:00
abstract：:The ontogeny of Ia antigen expression on cells within the decidua basalis of the placenta and on decidual cells differentiating in vitro was investigated in the mouse. The results indicate that Ia antigen expression is temporarily restricted and can be detected in short-term cultures of decidual tissue only during the...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80027-7
更新日期：1983-04-01 00:00:00
abstract：:Phorbol myristate acetate (PMA) and all-trans-retinal (retinal) were evaluated as possible phagocytic stimulators of cultured, post implantation, trophoblast cells. Ectoplacental cones dissected from 7.5 day-old mouse embryos provided the source of trophoblastic cells. Co-cultures were performed using stimulated and n...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(96)90033-8
更新日期：1996-09-01 00:00:00
abstract：:Epidermal growth factor (EGF) and its homologue, transforming growth factor-alpha (TGF-alpha), regulate human chorionic gonadotropin (hCG) synthesis in the human placenta. The current study was designed to investigate the involvement of the protein kinase C pathway in EGF-mediated hCG-beta production by JAr choriocarc...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(98)91040-2
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:Type 1 diabetes (T1D) is associated with adverse pregnancy outcome, usually attributed to hyperglycemia. Recently, we showed that pregnancy outcome in normoglycemic T1D rats was characterized by decreased fetal and placental weight, suggesting impaired placental development. In the present study, we tested...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.12.004
更新日期：2015-02-01 00:00:00
abstract：:Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2015.10.021
更新日期：2015-12-01 00:00:00
abstract：:Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2002.0941
更新日期：2003-05-01 00:00:00
abstract：:We have previously shown that thioredoxin and thioredoxin reductase were immunohistochemically localized in cytotrophoblasts, decidua and stromal cells in the stem villi of human placenta and that the addition of exogenous thioredoxin and thioredoxin reductase to mitochondrial fractions from human placenta displayed a...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.1999.0415
更新日期：1999-09-01 00:00:00
abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2003.11.011
更新日期：2004-07-01 00:00:00
abstract：INTRODUCTION AND METHODS:Tragulus, the mouse deer, is considered the most primitive ruminant, with a diffuse placenta grossly quite unlike the cotyledonary type of the other ruminants. This immunocytochemical investigation of placental transporters was designed to elucidate possible mechanisms of evolution to the cotyl...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.02.011
更新日期：2014-05-01 00:00:00
abstract：:Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2020.10.018
更新日期：2020-10-13 00:00:00
abstract：INTRODUCTION/OBJECTIVES:Recent studies suggest redness (color) discordance of the placental basal plate may be a marker for twin anemia-polycythemia sequence (TAPS), a recently described complication of diamniotic-monochorionic twinning characterized by marked intertwin hemoglobin (Hb) discordance in the absence of oli...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.10.007
更新日期：2017-12-01 00:00:00
abstract：:Placental development is a highly regulated process requiring signals from both fetal and maternal uterine compartments. Within this complex system, trophoblasts, placental cells of epithelial lineage, form the maternal-fetal interface controlling nutrient, gas and waste exchange. The commitment of progenitor villous ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2014.12.016
更新日期：2015-04-01 00:00:00
abstract：:During placental development, human cytotrophoblast cells can differentiate to either villous syncytiotrophoblast cells or invasive extravillous trophoblast cells. We hypothesize that oxygen tension plays a critical role in determining the pathway of cytotrophoblast differentiation. A highly purified preparation of cy...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2007.05.006
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:In humans, it is known that blood flow is directed to the gravid uterus from two (right and left) pelvic uterine arteries. The extent of supply from the tubo-ovarian anastomosis (joining of the ovarian and uterine arteries) is unknown. The aim of this study was to delineate the arterial blood supply to the p...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.10.009
更新日期：2010-01-01 00:00:00
abstract：:Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2006.01.020
更新日期：2007-01-01 00:00:00
abstract：:Angiotensinogen is the substrate for the enzyme renin. In addition to the well-characterized low molecular weight forms of angiotensinogen, a high molecular weight form (HMrA) comprises about 15 per cent of the total angiotensinogen in plasma of pregnant women. In the current study the different forms of angiotensinog...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80386-8
更新日期：1993-11-01 00:00:00
abstract：:A localized intrauterine inflammatory response is often associated with the initiation of normal human parturition, whereas infection causes a similar but more florid response initiating preterm labor. Pre-B-cell colony-enhancing factor (PBEF) is expressed in the human fetal membranes and is up-regulated by labor, sev...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2006.03.011
更新日期：2007-04-01 00:00:00
abstract：INTRODUCTION:Alterations of apoptosis are commonly associated with pregnancy complications and abortion. Modulation of apoptosis is a relevant feature of Toxoplasma gondii infection and it is related to parasite strain types. The aim of the present study was to evaluate the possible factors that are involved in the dif...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.09.005
更新日期：2013-11-01 00:00:00
abstract：:ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0749
更新日期：2002-01-01 00:00:00
abstract：:We present a case of intra-amniotic umbilical vein varix with thrombosis using conventional two-dimensional (2D) sonography, power Doppler, three-dimensional (3D) HD-flow, and HDlive at 35 weeks of gestation. 2D sonography showed a large banana-like umbilical cord enlargement (100 × 43.3 × 45.9 mm) including umbilical...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.08.008
更新日期：2013-11-01 00:00:00
