Oxygen tension directs the differentiation pathway of human cytotrophoblast cells.

abstract：:Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...

journal_title：Placenta

authors： Strid H,Bucht E,Jansson T,Wennergren M,Powell TL

更新日期：2003-05-01 00:00:00

abstract：:Human placental fragments concentrate 86Rb 10--20-fold during a two-hour incubation period. Inhibition of ouabain is dose-dependent, reaching 90 + per cent at a concentration of 5 x 10(-5) M. The clearance index of 86Rb across the perfused human placenta is 0.34 +/- 0.08, comparing to previously reported indices for N...

journal_title：Placenta

authors： Dancis J,Kammerman S,Jansen V,Levitz M

更新日期：1983-10-01 00:00:00

abstract：:The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...

journal_title：Placenta

authors： Thornburg KL,Kolahi K,Pierce M,Valent A,Drake R,Louey S

更新日期：2016-12-01 00:00:00

abstract：:The trophoblastic and endodermal tissues of the guinea pig were cytophotometrically examined at two stages of development, either shortly after the primary trophoblastic giant cell layer had degenerated (Sansom and Hill, 1931) and the visceral yolk sac was starting to form (Kaufman and Davidoff, 1977) (c. 10.5 days p....

journal_title：Placenta

authors： Ilgren EB

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study exam...

journal_title：Placenta

authors： Dubruc E,Lebreton F,Giannoli C,Rabilloud M,Huissoud C,Devouassoux-Shisheboran M,Allias F

更新日期：2016-12-01 00:00:00

abstract：:Apart from during the prepartal period, the main oestrogen produced by the bovine trophoblast is oestrone sulphate (E1S) which does not bind to nuclear oestrogen receptors (ER). High steroid sulphatase (StS) activities previously detected in the maternal part of bovine placentomes (caruncles) suggest the local activat...

journal_title：Placenta

authors： Greven H,Kowalewski MP,Hoffmann B,Geyer J,Rex-Haffner M,Ugele B,Schuler G

更新日期：2007-08-01 00:00:00

abstract：:Dynamics of genome multiplication during establishment of interrelations between trophoblast and glandular epithelium of the endometrium has been studied in the course of formation of placenta in the silver fox. During formation of the placenta, penetration of the trophoblast into the zone of the endometrial glandular...

journal_title：Placenta

authors： Zybina TG,Zybina EV,Kiknadze II,Zhelezova AI

更新日期：2001-05-01 00:00:00

abstract：:Chorioallantoic placentae were obtained from a reproductively synchronized wild population of greater mustache bats for ultrastructural and immunocytochemical examination. The single discoidal placenta was always located in a lateral to mesometrial position on the right side of the uterus, which in the non-pregnant st...

journal_title：Placenta

authors： Badwaik NK,Rasweiler JJ 4th

更新日期：1998-07-01 00:00:00

abstract：:It has been suggested that adenosine is involved in the acute effects of ethanol in a number of tissues. The present study was undertaken to evaluate the role of adenosine on the vascular responses of perfused isolated human placental cotyledons after the acute administration of ethanol. The possibility that ethanol m...

journal_title：Placenta

authors： Acevedo CG,Huambachano A,Perez E,Rojas S,Bravo I,Contreras E

更新日期：1997-07-01 00:00:00

abstract：INTRODUCTION:Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic c...

journal_title：Placenta

authors： Labarrere CA,Hardin JW,Haas DM,Kassab GS

更新日期：2015-06-01 00:00:00

abstract：:The intrauterine environment has an important influence on placental development. In pre-eclampsia (PE) and intrauterine growth restriction (IUGR), early remodelling of spiral arteries has repercussions for uteroplacental blood flow. The IUGR placenta exhibits compromised growth of villous trees, a smaller intervillou...

journal_title：Placenta

authors： Rainey A,Mayhew TM

更新日期：2010-07-01 00:00:00

abstract：:Neuropeptides play an important role in the regional regulation of blood flow and hormone secretion. Few studies report the presence of peptides in the human placenta. Our experiment evaluates neuropeptides in the human placenta using immunocytochemical techniques. Representative tissue sections from full-term placent...

journal_title：Placenta

authors： Graf AH,Hütter W,Hacker GW,Steiner H,Anderson V,Staudach A,Dietze O

更新日期：1996-09-01 00:00:00

abstract：:Confocal and conventional indirect immunofluorescence and immunogold electron microscopic methods were applied to examine the distribution of extracellular matrix constituents (collagens types III and IV) in the villi of immature and term human placentae. The immunofluorescence study revealed that collagen type III is...

journal_title：Placenta

authors： Nanaev AK,Rukosuev VS,Shirinsky VP,Milovanov AP,Domogatsky SP,Duance VC,Bradbury FM,Yarrow P,Gardiner L,d'Lacey C

更新日期：1991-11-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...

journal_title：Placenta

authors： David AL

更新日期：2017-11-01 00:00:00

abstract：:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....

journal_title：Placenta

authors： Umezawa A,Hasegawa A,Inoue M,Tanuma-Takahashi A,Kajiwara K,Makino H,Chikazawa E,Okamoto A

更新日期：2019-09-01 00:00:00

abstract：:The uptake of [3H]choline and its conversion to [3H]acetylcholine were investigated in term human placental tissue in vitro. Although the net uptake of [3H]choline increased throughout a 45 min incubation period, intracellular [3H]choline levels reach a plateau after 2 min. There was a constant increase in [3H]acetylc...

journal_title：Placenta

authors： Leventer SM,Rowell PP

更新日期：1984-05-01 00:00:00

abstract：:The placental endothelium contributes to regulating transplacental exchange and maintaining the immunological maternofetal barrier. We characterized the endothelial phenotype in human normal term placentae with a panel of antibodies to endothelial antigens using a standardized immunofluorescence method. Placental endo...

journal_title：Placenta

authors： Dye JF,Jablenska R,Donnelly JL,Lawrence L,Leach L,Clark P,Firth JA

更新日期：2001-01-01 00:00:00

abstract：:Placentae from both smoking and non-smoking mothers were studied with respect to P450-dependent xenobiotic and steroid-metabolizing reactions, GSHt activity with different substrates and umbilical blood cotinine levels. Catalytic activities were determined in both freshly prepared homogenate subfractions and subfracti...

journal_title：Placenta

authors： Pasanen M,Pelkonen O

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...

journal_title：Placenta

authors： Koppes E,Shaffer B,Sadovsky E,Himes K,Barak Y,Sadovsky Y,Chaillet JR

更新日期：2019-12-01 00:00:00

abstract：:Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...

journal_title：Placenta

authors： Novak D,Lehman M,Bernstein H,Beveridge M,Cramer S

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:The feto-maternal interface during bovine implantation was studied in vivo and using three-dimensional bovine endometrial (BCECph) and trophoblast spheroids (CCS), each with underlying fibroblasts. METHODS:The expression of ezrin and cytokeratin 18 (CK18) was analyzed via immunohistochemistry (IHC), RT-PC...

journal_title：Placenta

authors： Haeger JD,Hambruch N,Dantzer V,Hoelker M,Schellander K,Klisch K,Pfarrer C

更新日期：2015-08-01 00:00:00

abstract：:Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imagin...

journal_title：Placenta

authors： Lewis RM,Pearson-Farr JE

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To study the expression of angiotensin II (ANG II) receptor subtype 1 (AT(1)R) in the human placenta with pregnancy-induced hypertension (PIH). METHODS:Immunohistochemistry was used to detect the expression of AT(1)R in placental tissues of 30 patients with PIH and 10 patients with normal pregnancies (contro...

journal_title：Placenta

authors： Thapa L,He CM,Chen HP

更新日期：2004-08-01 00:00:00

abstract：:The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...

journal_title：Placenta

authors： Wen HY,Abbasi S,Kellems RE,Xia Y

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder unique to pregnancy that is associated with increased rates of fetal distress and demise. While acute hypoxia is believed to cause the pathophysiology of ICP, direct molecular evidence for this is lacking. Here, we analyzed expression of three...

journal_title：Placenta

authors： Wei W,Hu YY

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Miscarriage is the most common placental-related complication of pregnancy. It has been extensively investigated to discover the underlying mechanism(s) by which miscarriage occurs, but in many cases the etiology still remains unclear. The aim of this study was to analyze genome-wide expression profiles of...

journal_title：Placenta

authors： Lyu SW,Song H,Yoon JA,Chin MU,Sung SR,Kim YS,Lee WS,Yoon TK,Cha DH,Shim SH

更新日期：2013-02-01 00:00:00

abstract：:Amniotic fluid exerts a protective function and is an essential component for foetal development and maturation during pregnancy. However, little is known about the exact physiological functions of foetal fluids in this process as well as their biochemical composition in cats. In the present study, the biochemical com...

journal_title：Placenta

authors： Fresno L,Rodriguez-Gil JE,Rigau T,Pastor J,Rivera del Alamo MM

更新日期：2012-06-01 00:00:00

abstract：:To characterize the placental activity for the transport of amino acids, the uptake of L-alanine was investigated by rapid membrane filtration using brush border membrane vesicles separated from the human placenta of early pregnant (12-13 gestational weeks) and late pregnant (37-38 gestational weeks) women. The uptake...

journal_title：Placenta

authors： Iioka H,Hisanaga H,Moriyama IS,Akada S,Shimamoto T,Yamada Y,Ichijo M

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Scant data on placental lymphatic vessels have pointed to the absence of lymphatic circulation. A recent study on mesenchymal dysplasia (MD), however, has identified pathologic lymphangiogenesis using the D2-40 lymphatic marker. These conflicting data have prompted us to investigate whether lymphatic vessels...

journal_title：Placenta

authors： Castro E,Tony Parks W,Galambos C

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Alterations of apoptosis are commonly associated with pregnancy complications and abortion. Modulation of apoptosis is a relevant feature of Toxoplasma gondii infection and it is related to parasite strain types. The aim of the present study was to evaluate the possible factors that are involved in the dif...

journal_title：Placenta

authors： Angeloni MB,Guirelli PM,Franco PS,Barbosa BF,Gomes AO,Castro AS,Silva NM,Martins-Filho OA,Mineo TW,Silva DA,Mineo JR,Ferro EA

更新日期：2013-11-01 00:00:00