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SNAT expression in rat placenta.

Abstract：

:Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstrated the presence of mRNA encoding three of these transporters, SNAT1, 2, and 4 within the rat placenta over the final third of gestation. Abundance of these mRNA species increases from day 14 to day 20 of gestation. Immunohistochemistry demonstrates the presence of SNAT1 and 2 within the placental labyrinth at both days 14 and 20. Transport proteins are also present within marginal giant cells and, for SNAT1, within fetal endothelium. In conclusion, several proteins capable of SysA transport activity are present within the rodent placenta. mRNA expression increases over the final third of gestation, coincident with the period of greatest need for fetal amino acid delivery.

journal_name

Placenta

journal_title

Placenta

authors

Novak D,Lehman M,Bernstein H,Beveridge M,Cramer S

doi

10.1016/j.placenta.2005.05.002

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

510-6

issue

4-5

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(05)00140-2

journal_volume

27

pub_type

杂志文章

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